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公开(公告)号：US11952434B2
公开(公告)日：2024-04-09
申请号：US17725340
申请日：2022-04-20
Applicant: Bristol-Myers Squibb Company
Inventor： Kevin W. Gillman , Jason Goodrich , Kenneth M. Boy , Yunhui Zhang , Claudio Mapelli , Michael A. Poss , Paul Michael Scola , David R. Langley , Nicholas A. Meanwell
CPC classification number: C07K7/08 , A61K38/10 , A61K45/06 , A61K51/088 , C07K7/56 , A61K38/00 , Y02A50/30
Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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公开(公告)号：US11103605B2
公开(公告)日：2021-08-31
申请号：US16098765
申请日：2017-05-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： David J. Donnelly , Kenneth M. Boy , Yunhui Zhang , Joonyoung Kim , Adrienne Pena
Abstract: The invention relates to the synthesis and use of 18F-labeled millamolecules for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.
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公开(公告)号：US09856292B2
公开(公告)日：2018-01-02
申请号：US14938327
申请日：2015-11-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kevin W. Gillman , Jason Goodrich , Kenneth M. Boy , Yunhui Zhang , Claudio Mapelli , Michael A. Poss , Paul Michael Scola , David R. Langley , Nicholas A. Meanwell
CPC classification number: C07K7/08 , A61K38/00 , A61K38/10 , A61K45/06 , A61K51/088 , C07K7/56 , Y02A50/463
Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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公开(公告)号：US20130178462A1
公开(公告)日：2013-07-11
申请号：US13785171
申请日：2013-03-05
Applicant: Bristol-Myers Squibb Company
Inventor： Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
IPC: C07D239/70 , C07D491/08 , C07D471/04 , C07D403/14 , C07D491/107 , C07D403/12
CPC classification number: C07D403/12 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/14 , C07D407/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/048 , C07D491/052 , C07D491/08 , C07D491/107 , C07D491/113
Abstract: The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Abstract translation: 本公开提供了一系列调节β-淀粉样肽（β-AP）产生的式（I）化合物，并且可用于治疗阿尔茨海默病和其它受β-淀粉样蛋白肽（β-AP）产生影响的病症 。
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公开(公告)号：US11358988B2
公开(公告)日：2022-06-14
申请号：US16711105
申请日：2019-12-11
Applicant: Bristol-Myers Squibb Company
Inventor： Kevin W. Gillman , Jason Goodrich , Kenneth M. Boy , Yunhui Zhang , Claudio Mapelli , Michael A. Poss , Paul Michael Scola , David R. Langley , Nicholas A. Meanwell
Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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Patent Agency Ranking
公开(公告)号：US20190117801A1
公开(公告)日：2019-04-25
申请号：US16098765
申请日：2017-05-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： David J. Donnelly , Kenneth M. Boy , Yunhui Zhang , Joonyoung KIM , Adrienne Pena
Abstract: The invention relates to the synthesis and use of 18F-labeled millamolecules for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.
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公开(公告)号：US20150152089A1
公开(公告)日：2015-06-04
申请号：US14616008
申请日：2015-02-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
IPC: C07D403/12 , C07D401/14 , C07D491/048 , C07D413/14 , C07D491/052 , C07D403/14 , C07D491/08
CPC classification number: C07D403/12 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/14 , C07D407/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/048 , C07D491/052 , C07D491/08 , C07D491/107 , C07D491/113
Abstract: The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
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公开(公告)号：US20180086793A1
公开(公告)日：2018-03-29
申请号：US15822744
申请日：2017-11-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kevin W. Gillman , Jason Goodrich , Kenneth M. Boy , Yunhui Zhang , Claudio Mapelli , Michael A. Poss , Paul Michael Scola , David R. Langley , Nicholas A. Meanwell
CPC classification number: C07K7/08 , A61K38/00 , A61K38/10 , A61K45/06 , A61K51/088 , C07K7/56 , Y02A50/463
Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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公开(公告)号：US20160137696A1
公开(公告)日：2016-05-19
申请号：US14938327
申请日：2015-11-11
Applicant: Bristol-Myers Squibb Company
Inventor： Kevin W. Gillman , Jason Goodrich , Kenneth M. Boy , Yunhui Zhang , Claudio Mapelli , Michael A. Poss , Li-Qiang Sun , Qian Zhao , Eric Mull , Eric P. Gillis , Paul Michael Scola
CPC classification number: C07K7/08 , A61K38/00 , A61K38/10 , A61K45/06 , A61K51/088 , C07K7/56 , Y02A50/463
Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Abstract translation: 本公开提供了作为免疫调节剂的化合物，因此可用于改善各种疾病，包括癌症和感染性疾病。
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公开(公告)号：US20150336975A1
公开(公告)日：2015-11-26
申请号：US14816405
申请日：2015-08-03
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kenneth M. Boy , Jason M. Guernon , John E. Macor , Richard E. Olson , Jianliang Shi , Lorin A. Thompson, III , Yong-Jin Wu , Li Xu , Yunhui Zhang , Dmitry S. Zuev
IPC: C07D491/113 , C07D403/14 , C07D491/048 , C07D491/08 , C07D413/14 , C07D491/052 , C07D403/12 , C07D401/14
CPC classification number: C07D403/12 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/14 , C07D407/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/048 , C07D491/052 , C07D491/08 , C07D491/107 , C07D491/113
Abstract: The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Abstract translation: 本公开提供了一系列式（I）的化合物，其调节和淀粉样蛋白肽（＆bgr; -AP）产生，并且可用于治疗阿尔茨海默氏病和其它受β-淀粉状蛋白肽（＆bgr; -AP）生产。
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