公开(公告)号：US20190117801A1

公开(公告)日：2019-04-25

申请号：US16098765

申请日：2017-05-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： David J. Donnelly ,  Kenneth M. Boy ,  Yunhui Zhang ,  Joonyoung KIM ,  Adrienne Pena

IPC: A61K51/08 ,  C07K7/08 ,  A61B6/03 ,  A61B6/12

Abstract: The invention relates to the synthesis and use of 18F-labeled millamolecules for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.

公开(公告)号：US11103605B2

公开(公告)日：2021-08-31

申请号：US16098765

申请日：2017-05-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： David J. Donnelly ,  Kenneth M. Boy ,  Yunhui Zhang ,  Joonyoung Kim ,  Adrienne Pena

IPC: A61K51/08 ,  A61B6/03 ,  A61B6/12 ,  C07K7/08

Abstract: The invention relates to the synthesis and use of 18F-labeled millamolecules for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.

公开(公告)号：US09987381B2

公开(公告)日：2018-06-05

申请号：US15032486

申请日：2014-10-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  YALE UNIVERSITY

Inventor： Thomas Jon Seiders ,  David J. Donnelly ,  Samuel J. Bonacorsi, Jr. ,  Kai Cao ,  Tritin Tran ,  Adrienne Pena ,  Joonyoung Kim ,  Richard E. Carson ,  Nabeel Nabulsi ,  Jean-Dominique Gallezot ,  Yiyun Huang ,  Jeffrey Roger Roppe

IPC: A61K51/04 ,  C07D261/14 ,  C07B59/00 ,  A61B6/00

CPC classification number: A61K51/0453 ,  A61B6/481 ,  C07B59/002 ,  C07B2200/05 ,  C07D261/14

Abstract: The present invention relates to radiolabeled LPA1 receptor antagonists or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of LPA1 receptors in mammals.

公开(公告)号：US20160256577A1

公开(公告)日：2016-09-08

申请号：US15032486

申请日：2014-10-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  YALE UNIVERSITY

Inventor： Thomas Jon Seiders ,  David J. Donnelly ,  Samuel J. Bonacorsi, JR. ,  Kai Cao ,  Tritin Tran ,  Adrienne Pena ,  Joonyoung Kim ,  Richard E. Carson ,  Nabel Nabulsi ,  Jean-Dominique Gallezot ,  Yiyun Huang ,  Jeffrey Roger Roppe

IPC: A61K51/04 ,  A61B6/00 ,  C07D261/14

CPC classification number: A61K51/0453 ,  A61B6/481 ,  C07B59/002 ,  C07B2200/05 ,  C07D261/14

Abstract: The present invention relates to radiolabeled LPA1 receptor antagonists or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of LPA1 receptors in mammals.

Abstract translation: 本发明涉及放射性标记的LPA1受体拮抗剂或其药学上可接受的盐，其可用于哺乳动物中LPA1受体的定量成像。