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    Anti-migration micropatterned stent coating
    4.
    发明授权
    Anti-migration micropatterned stent coating 有权
    抗迁移微图案支架涂层

    公开(公告)号：US09517122B2

    公开(公告)日：2016-12-13

    申请号：US14210979

    申请日：2014-03-14

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Laura Elizabeth Firstenberg ,  Sean P. Fleury

    IPC: A61F2/07 ,  A61F2/06 ,  A61F2/848 ,  A61F2/00 ,  A61F2/04

    CPC classification number: A61F2/848 ,  A61F2/0077 ,  A61F2/04 ,  A61F2/06 ,  A61F2/064 ,  A61F2/07 ,  A61F2002/0081 ,  A61F2002/044 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/077 ,  A61F2002/8483 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2250/0063 ,  Y10T156/10

    Abstract: An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.

    Abstract translation: 内假体具有扩张状态和未展开状态，内假体包括支架，其中支架具有第一端，第二端，限定内腔的内表面，外表面和限定在内表面和内表面之间的厚度 外表面 以及设置在所述第一和第二端中的一个上的支架端盖，所述支架端盖包括聚合物涂层，所述聚合物涂层包括基部和多个突起，所述基部包括面向所述支架的外表面的第一主表面， 还包括第二主表面，所述多个突起中的每一个从所述第二主表面向外延伸，所述第一主表面与所述第二主表面相对，其中所述突起被布置在微图案中。 提供制造和使用内置假体的方法。

    Anti-migration micropatterned stent coating
    7.
    发明授权
    Anti-migration micropatterned stent coating 有权

    公开(公告)号：US10342684B2

    公开(公告)日：2019-07-09

    申请号：US15340465

    申请日：2016-11-01

    Applicant: BOSTON SCIENTIFIC SCIMED, INC.

    Inventor： Laura Elizabeth Firstenberg ,  Sean P. Fleury

    IPC: A61F2/848 ,  A61F2/06 ,  A61F2/07 ,  A61F2/00 ,  A61F2/04

    Abstract: An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.

    SUPERHYDROPHOBIC COATING FOR AIRWAY MUCUS PLUGGING PREVENTION
    8.
    发明申请
    SUPERHYDROPHOBIC COATING FOR AIRWAY MUCUS PLUGGING PREVENTION 有权
    超声波涂料用于空中运输防护

    公开(公告)号：US20140277443A1

    公开(公告)日：2014-09-18

    申请号：US14210612

    申请日：2014-03-14

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Sean P. Fleury ,  Mark D. Wood ,  Dane T. Seddon ,  Laura Elizabeth Firstenberg ,  Paul Smith ,  Gary J. Leanna ,  Claude O. Clerc ,  James Weldon ,  Steven E. Walak

    IPC: A61L31/14 ,  A61F2/82

    CPC classification number: A61L31/14 ,  A61F2/0077 ,  A61F2/07 ,  A61F2/82 ,  A61F2/86 ,  A61F2002/043 ,  A61F2230/0067 ,  A61F2230/0091 ,  A61F2250/0026 ,  A61F2250/0039 ,  A61F2250/0051 ,  A61F2250/0056 ,  A61L31/10 ,  A61L2400/12 ,  A61L2400/18 ,  C08L27/18 ,  C08L23/12

    Abstract: A method for reducing mucus accumulation in an airway including disposing an implantable device within an airway, wherein the implantable device has a first end, a second end, and an inner surface defining a lumen extending from the first end to the second end; wherein at least a portion of the inner surface has a hydrophobic polymer coating thereon, wherein a polymer coating surface has dynamic water contact angles of 145 degrees or greater; and wherein the implantable device is constructed and arranged to maintain patency of the airway; wherein accumulation of mucus is reduced as compared to a similar implantable device without the hydrophobic portion of the inner surface. An implantable medical device having a superhydrophobic surface and a method of making an implantable medical device having a superhydrophobic surface are also provided. An implantable medical device having a micropatterned surface with enhanced adhesion to tissue, optionally in combination with other region(s) having a superhydrophobic surface and a method of making such a device. Methods and devices for prevention of bacterial adhesion to implanted medical devices.

    Abstract translation: 一种用于减少气道中的粘液累积的方法，包括在气道内设置可植入装置，其中所述可植入装置具有第一端，第二端和限定从所述第一端延伸到所述第二端的内腔的内表面; 其中所述内表面的至少一部分在其上具有疏水聚合物涂层，其中聚合物涂层表面具有145度或更大的动态水接触角; 并且其中所述可植入装置被构造和布置成保持所述气道的通畅; 其中与不具有内表面的疏水部分的类似可植入装置相比，粘液的积聚减少。 还提供了具有超疏水表面的可植入医疗装置和制造具有超疏水表面的可植入医疗装置的方法。 一种植入式医疗装置，其具有对组织增强的附着力的微图案化表面，任选地与具有超疏水表面的其它区域组合，以及制造这种装置的方法。 用于防止植入医疗器械细菌粘附的方法和装置。

    ANTI-MIGRATION MICROPATTERNED STENT COATING
    9.
    发明申请
    ANTI-MIGRATION MICROPATTERNED STENT COATING 有权
    防移动微电脑涂层

    公开(公告)号：US20140277395A1

    公开(公告)日：2014-09-18

    申请号：US14210979

    申请日：2014-03-14

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Laura Elizabeth Firstenberg ,  Sean P. Fleury

    IPC: A61F2/06

    CPC classification number: A61F2/848 ,  A61F2/0077 ,  A61F2/04 ,  A61F2/06 ,  A61F2/064 ,  A61F2/07 ,  A61F2002/0081 ,  A61F2002/044 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/077 ,  A61F2002/8483 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2250/0063 ,  Y10T156/10

    Abstract: An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.

    Abstract translation: 内假体具有扩张状态和未展开状态，内假体包括支架，其中支架具有第一端，第二端，限定内腔的内表面，外表面和限定在内表面和内表面之间的厚度 外表面 以及设置在所述第一和第二端中的一个上的支架端盖，所述支架端盖包括聚合物涂层，所述聚合物涂层包括基部和多个突起，所述基部包括面向所述支架的外表面的第一主表面， 还包括第二主表面，所述多个突起中的每一个从所述第二主表面向外延伸，所述第一主表面与所述第二主表面相对，其中所述突起被布置在微图案中。 提供制造和使用内置假体的方法。

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