专利检索 ap:("BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM") AND inv:"Yang CHEN" 第 1 页

1.

发明申请
COMPOSITIONS FOR AND METHODS OF PRODUCING TUMOR ORGANOIDS 有权

公开(公告)号：US20210371825A1

公开(公告)日：2021-12-02

申请号：US17285908

申请日：2019-10-16

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Raghu KALLURI , Valerie LEBLEU , Yang CHEN

IPC分类号： C12N5/071 , C12N5/09 , G01N33/50

摘要： Provided herein are methods of enhancing the production of organoids from primary tissues, which can be either normal or cancerous, by culturing the primary tissues in the presence of collagen I homotrimers. To this end, also provided are cell culture media comprising exogenous collagen I homotrimers. Also provided are organoids produced by the disclosed methods as well as methods of using the organoids so produced.

2.

发明申请
IDENTIFICATION AND TARGETING OF PATHOGENIC EXTRACELLULAR MATRIX FOR DIAGNOSIS AND TREATMENT OF CANCER AND OTHER DISEASES 有权

公开(公告)号：US20220144926A1

公开(公告)日：2022-05-12

申请号：US17286206

申请日：2019-10-16

申请人： Board of Regents, The University of Texas System

发明人： Raghu KALLURI , Valerie LEBLEU , Yang CHEN

IPC分类号： C07K16/18 , C07K16/28 , A61K45/06 , A61K35/17 , A61P35/00 , G01N33/574

摘要： Provided herein are agents, such as antibodies or chimeric antigen receptors, that target homotrimeric type I collagen. Methods of treating cancer and fibroids are provided, comprising administering to a patient in need thereof an effective amount of a homotrimeric type I collagen-neutralizing agent. The methods can further include administering an effective amount of chemotherapy or immunotherapy to said patient.