- 专利标题： IDENTIFICATION AND TARGETING OF PATHOGENIC EXTRACELLULAR MATRIX FOR DIAGNOSIS AND TREATMENT OF CANCER AND OTHER DISEASES
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申请号： US17286206申请日： 2019-10-16
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公开(公告)号： US20220144926A1公开(公告)日： 2022-05-12
- 发明人: Raghu KALLURI , Valerie LEBLEU , Yang CHEN
- 申请人： Board of Regents, The University of Texas System
- 申请人地址： US TX Austin
- 专利权人： Board of Regents, The University of Texas System
- 当前专利权人： Board of Regents, The University of Texas System
- 当前专利权人地址： US TX Austin
- 国际申请： PCT/US2019/056576 WO 20191016
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; C07K16/28 ; A61K45/06 ; A61K35/17 ; A61P35/00 ; G01N33/574
摘要：
Provided herein are agents, such as antibodies or chimeric antigen receptors, that target homotrimeric type I collagen. Methods of treating cancer and fibroids are provided, comprising administering to a patient in need thereof an effective amount of a homotrimeric type I collagen-neutralizing agent. The methods can further include administering an effective amount of chemotherapy or immunotherapy to said patient.
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