公开(公告)号：US20200040385A1

公开(公告)日：2020-02-06

申请号：US16596596

申请日：2019-10-08

Applicant: NanoString Technologies, Inc. ,  Board of Regents, The University of Texas System

Inventor： Joseph M. BEECHEM ,  Charles WARREN ,  Chris MERRITT ,  Jaemyeong JUNG ,  Dwayne L. DUNAWAY ,  Scott CROWDER ,  Kristina SORG ,  Gordon B. MILLS

IPC: C12Q1/6841 ,  C12Q1/6823 ,  G01N33/68

Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.

公开(公告)号：US20250066860A1

公开(公告)日：2025-02-27

申请号：US18815430

申请日：2024-08-26

Applicant: The Johns Hopkins University ,  Board of Regents, The University of Texas System ,  The Research Foundation for The State University of New York

Inventor： Bert Vogelstein ,  Kenneth W. Kinzler ,  Joshua David Cohen ,  Nickolas Papadopoulos ,  Anne Marie Lennon ,  Cristian Tomasetti ,  Yuxuan Wang ,  Georges Jabboure Netto ,  Rachel Karchin ,  Christopher Douville ,  Samir Hanash ,  Simeon Springer ,  Arthur P. Grollman ,  Kathleen Dickman

IPC: C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6858 ,  C12Q1/686 ,  C12Q1/6869

Abstract: Provided herein are methods and materials for detecting and/or treating subject (e.g., a human) having cancer. In some embodiments, methods and materials for identifying a subject as having cancer (e.g., a localized cancer) are provided in which the presence of member(s) of two or more classes of biomarkers are detected. In some embodiments, methods and materials for identifying a subject as having cancer (e.g., a localized cancer) are provided in which the presence of member(s) of at least one class of biomarkers and the presence of aneuploidy are detected. In some embodiments, methods described herein provide increased sensitivity and/or specificity in the detection of cancer in a subject (e.g. a human).

公开(公告)号：US20250042991A1

公开(公告)日：2025-02-06

申请号：US18765613

申请日：2024-07-08

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Zhiqiang AN ,  Ningyang ZHANG ,  Philipp E. SCHERER ,  Shangang ZHAO

IPC: C07K16/26 ,  A61K39/00 ,  A61P3/04

Abstract: Antibody antigen binding domains which specifically binds human leptin comprises VH or VL CDR1, CDR2 and CDR3 sequences of an hLept antibody. The antibody antigen binding domains and antibodies thereof are useful to treat obesity and diabetes.

公开(公告)号：US12218968B1

公开(公告)日：2025-02-04

申请号：US17717474

申请日：2022-04-11

Applicant: Board of Regents, The University of Texas System

Inventor： Elias Bou Harb ,  Morteza Safaei Pour

IPC: H04L9/40

Abstract: A method and system for detecting and analyzing internet traffic from Internet of Things (IoT) devices is presented. A network telescope is employed to collect unsolicited data packets. The data packets are analyzed to determine whether they arise from a misconfigured device or from a malicious device (darknet sanitization) or from some other source. Traffic from misconfigured devices is filtered out. The data packets from malicious devices are analyzed and a classification model is trained to classify the data packets into originating from an IoT or from a non-IoT device. The classifier is then validated on a separate set of data. The data packets originating from malicious IoT devices are further analyzed by such techniques a clustering (e.g. agglomerative hierarchical clustering), geo-location analysis, methods of attack, and coordination of attacks.

公开(公告)号：US20250034617A1

公开(公告)日：2025-01-30

申请号：US18716820

申请日：2022-12-06

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  SAN JOSE STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Can CENIK ,  Crystal M. HAN

IPC: C12Q1/6806 ,  C12Q1/6869

Abstract: The present disclosure provides methods for profiling the nucleic acids bound to the ribosome by using electrophoresis to separate the nucleic acids bound to the ribosome from a cell lysate. Also, provided herein are devices that may be used to separate these nucleic acids from other parts of the cell and may be used in these methods.

公开(公告)号：US20250032506A1

公开(公告)日：2025-01-30

申请号：US18716052

申请日：2022-12-05

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Li MA

IPC: A61K31/567 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

Abstract: The present disclosure provides methods of treating a subject having a pancreatic cancer that does not respond to an immune checkpoint inhibitor (ICI) therapy comprising administering to the subject in need thereof a combination therapy comprising one or more glucocorticoid receptor antagonists, or pharmaceutically acceptable salts thereof, and one or more immune checkpoint inhibitor selected from the group consisting of a PD-1 antagonist, a PD-L1 antagonist, a CTLA-4 antagonist, or any combination thereof, thereby treating the subject in need thereof.

公开(公告)号：US20250025074A1

公开(公告)日：2025-01-23

申请号：US18773701

申请日：2024-07-16

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Nanshu Lu ,  Philip Tan ,  Eric Wang ,  Sarnab Bhattacharya

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/024

Abstract: Disclosed and described herein are systems, methods and device for providing simultaneous non-invasive arterial and venous oxygen saturation. An ultra-thin and self-adherable optical electronic tattoo measures blood absorbance changes from multiple locations. Another sensor may be included to provide self-calibration. Using algorithms, the signals from the blood from the artery and vein can be better separated and yield accurate blood oxygen assessments.

公开(公告)号：US12203138B2

公开(公告)日：2025-01-21

申请号：US17182846

申请日：2021-02-23

Applicant: Board of Regents, The University of Texas System

Inventor： Mariano A. Garcia-Blanco ,  Gaddiel Galarza-Munoz ,  Simon G. Gregory ,  Farren B. S. Briggs ,  Lisa F. Barcellos ,  Shelton S. Bradrick ,  Irina Evsyukova ,  Dennis C. Ko

IPC: C12Q1/68 ,  C12Q1/34 ,  C12Q1/6806 ,  C12Q1/6883 ,  C12Q1/683 ,  C12Q1/6851 ,  C12Q1/686

Abstract: The present invention includes a method, kits, and assays for identifying a human subject as having an increased risk of developing an autoimmune disease, or a human subject with multiple sclerosis caused by elevated soluble Interleukin 7 receptor (sIL7R), by obtaining a biological sample and detecting or measuring in the biological sample an amount of a soluble Interleukin-7 receptor (sIL7R) and an amount of an RNA Helicase DDX39B, whereby a lower expression of DDX39B and a higher secretion of sIL7R identifies the subject from which the biological sample was obtained as having an increased risk of developing an autoimmune disease, when compared to a human subject not having an autoimmune disease. The present invention also includes a method of modifying a treating of subjects based on the lower expression of RNA Helicase DDX39B alone or in combination with an increase in sIL7R.

公开(公告)号：US12202877B2

公开(公告)日：2025-01-21

申请号：US17048748

申请日：2019-04-19

Applicant: Board of Regents, The University of Texas System

Inventor： Cassian Yee ,  Ke Pan

IPC: C07K16/00 ,  A61K39/00 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783 ,  A61K38/00

Abstract: The present disclosure provides methods for generating MAGE-B2 specific T cells and compositions comprising engineered MAGE-B2-specific T cell receptors. Further provided are methods of treating cancer comprising administering the MAGE-B2-specific T cells.

公开(公告)号：US12201684B2

公开(公告)日：2025-01-21

申请号：US16937967

申请日：2020-07-24

Applicant: The Board of Regents, The University of Texas System

Inventor： Burton Dickey ,  Michael Tuvim ,  Scott Evans

IPC: A61K39/39 ,  A61K9/00 ,  A61K31/7125 ,  A61K38/08 ,  A61K45/06 ,  A61K39/00

Abstract: Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a StIR composition to the individual.