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    One-step processing of hydrogels for mechanically robust and chemically desired features
    1.
    发明授权
    One-step processing of hydrogels for mechanically robust and chemically desired features 有权

    公开(公告)号：US10279042B2

    公开(公告)日：2019-05-07

    申请号：US14604298

    申请日：2015-01-23

    申请人： Board of Regents, The University of Texas System

    发明人： Sarah Mayes ,  Christine Schmidt

    IPC分类号： A61K31/738 ,  A61K31/7008 ,  A61K31/734 ,  A61K31/728 ,  A61K47/36

    摘要： The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.

    One-Step Processing of Hydrogels for Mechanically Robust and Chemically Desired Features
    3.
    发明申请
    One-Step Processing of Hydrogels for Mechanically Robust and Chemically Desired Features 有权

    公开(公告)号：US20220160877A1

    公开(公告)日：2022-05-26

    申请号：US17669455

    申请日：2022-02-11

    申请人： Board of Regents, The University of Texas System

    发明人： Sarah Mayes ,  Christine Schmidt

    IPC分类号： A61K47/36 ,  A61K31/738

    摘要： The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.

    One-Step Processing of Hydrogels for Mechanically Robust and Chemically Desired Features
    5.
    发明申请
    One-Step Processing of Hydrogels for Mechanically Robust and Chemically Desired Features 审中-公开
    用于机械稳定和化学需要的特征的水凝胶的一步加工

    公开(公告)号：US20150133377A1

    公开(公告)日：2015-05-14

    申请号：US14604298

    申请日：2015-01-23

    申请人： Board of Regents, The University of Texas System

    发明人： Sarah Mayes ,  Christine Schmidt

    IPC分类号： A61K47/36

    CPC分类号： A61K47/36 ,  A61K31/738

    摘要： The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.

    摘要翻译： 在本发明中描述了高度控制的微米尺寸的支化多孔结构的应用以增强水凝胶的处理性能和降解速率。 在水凝胶膜中通过一步成核结晶产生的先前描述的图案产生用于组织工程应用的可调谐的机械性能和/或化学稳定性。 材料的体积机械性能和降解速率可以通过加入或减少晶体结构或通过添加和减少回填材料来轻松调整，使其适用于各种应用。 通过应用这种独特的孔隙可以调节的相关机械性能是模量，弹性，拉伸强度和抗压强度。 本发明的方法可以应用于生物聚合物和天然材料以及合成材料。

    One-Step Processing of Hydrogels for Mechanically Robust and Chemically Desired Features
    6.
    发明公开
    One-Step Processing of Hydrogels for Mechanically Robust and Chemically Desired Features 审中-公开

    公开(公告)号：US20240307543A1

    公开(公告)日：2024-09-19

    申请号：US18430697

    申请日：2024-02-02

    申请人： Board of Regents, The University of Texas System

    发明人： Sarah Mayes ,  Christine Schmidt

    IPC分类号： A61K47/36 ,  A61K31/738

    CPC分类号： A61K47/36 ,  A61K31/738

    摘要： The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.

    One-Step Processing of Hydrogels for Mechanically Robust and Chemically Desired Features
    9.
    发明申请
    One-Step Processing of Hydrogels for Mechanically Robust and Chemically Desired Features 审中-公开

    公开(公告)号：US20190216933A1

    公开(公告)日：2019-07-18

    申请号：US16358948

    申请日：2019-03-20

    申请人： Board of Regents, The University of Texas System

    发明人： Sarah Mayes ,  Christine Schmidt

    IPC分类号： A61K47/36 ,  A61K31/738

    CPC分类号： A61K47/36 ,  A61K31/738

    摘要： The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.