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1.发明授权Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid 有权用于递送3-氨基-1-丙磺酸的方法，化合物，组合物和载体公开(公告)号：US09499480B2
公开(公告)日：2016-11-22
申请号：US14246894
申请日：2014-04-07
发明人： Xianqi Kong , Mohamed Atfani , Benoit Bachand , Abderrahim Bouzide , Stephane Ciblat , Sophie Levesque , David Migneault , Isabelle Valade , Xinfu Wu , Daniel Delorme
IPC分类号： C07D285/36 , C07D323/02 , C07D285/38 , C07D333/24 , C07D217/24 , C07D291/02 , C07D233/64 , C07D209/20 , C07K5/068 , C07K5/062 , C07C309/24 , A61K47/48 , C07C309/19 , C12P13/00 , C07C309/18 , C07H15/12 , C07H7/02 , C07J9/00 , C12P11/00 , C07C309/15 , C07K5/083 , C07D207/16
CPC分类号： A61K31/145 , A61K47/54 , A61K47/542 , A61K47/545 , A61K47/549 , A61K47/554 , A61K47/64 , C07C309/15 , C07C309/18 , C07C309/19 , C07C309/24 , C07D207/16 , C07D209/20 , C07D217/24 , C07D233/64 , C07D285/36 , C07D285/38 , C07D291/02 , C07D323/02 , C07D333/24 , C07H7/02 , C07H15/12 , C07J9/005 , C07K5/06026 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/0806 , C07K5/081 , C12P11/00 , C12P13/001 , Y02P20/55
摘要： The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compound that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to the prevention and treatment of Alzheimer's disease.
摘要翻译： 本发明涉及在受试者，优选人受试者中递送3-氨基-1-丙磺酸（3APS）的方法，化合物，组合物和载体。 本发明包括在体外或体内产生或产生3APS的化合物。 优选的化合物包括3APS的氨基酸前药，包括但不限于预防和治疗阿尔茨海默氏病。
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2.发明授权公开(公告)号：US10238611B2
公开(公告)日：2019-03-26
申请号：US15293965
申请日：2016-10-14
发明人： Xianqi Kong , Mohamed Atfani , Benoit Bachand , Abderrahim Bouzide , Stephane Ciblat , Sophie Levesque , David Migneault , Isabelle Valade , Xinfu Wu , Daniel Delorme
IPC分类号： A61K31/145 , A61K47/54 , C07C309/18 , C07C309/19 , C07C309/24 , C07D333/24 , C07D317/40 , A61K47/64 , C07J9/00 , C07D285/38 , C07H7/02 , C07D323/02 , C07H15/12 , C12P13/00 , C07D285/36 , C07D291/02 , C07K5/062 , C12P11/00 , C07D233/64 , C07D217/24 , C07D209/20 , C07D207/16 , C07C309/15 , C07K5/083 , C07K5/068
摘要： The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compound that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to the prevention and treatment of Alzheimer's disease.
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