公开(公告)号：US11776174B1

公开(公告)日：2023-10-03

申请号：US18111879

申请日：2023-02-20

申请人： BEIHANG UNIVERSITY

发明人： Jie Tian ,  Yu An ,  Guanghui Li ,  Yang Du ,  Daxiang Yan ,  Jiaqian Li

IPC分类号： G06T11/00 ,  G06T7/33 ,  G06T7/73 ,  G06T7/50 ,  G06T9/00 ,  G06T7/00 ,  A61B5/00 ,  A61B5/0515 ,  G06T7/136

CPC分类号： G06T11/008 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0515 ,  G06T7/0012 ,  G06T7/136 ,  G06T7/33 ,  G06T7/50 ,  G06T7/73 ,  G06T9/00 ,  G06T11/005 ,  G06T2200/04 ,  G06T2207/10064 ,  G06T2207/10081 ,  G06T2207/10101 ,  G06T2207/30096 ,  G06T2211/424

摘要： A fluorescence molecular tomography reconstruction method includes: obtaining an MPI three-dimensional tomographic image, a body surface near-infrared fluorescence two-dimensional image, and a CT image; constructing an SIS capable of accommodating the ROI, and discretizing the SIS by using a finite element method; performing data mapping to obtain detected surface fluorescence signals, a prior of the anatomical structure of tissues and organs around the tumor and a prior of the tumor; performing forward model calculation to obtain a system matrix and constructing an objective function; iteratively solving the objective function based on the Laplacian regularization matrix to obtain a fluorescence molecular tomography reconstruction result; the present invention adopts MPI to guide the FMT, achieving complete morphology and structure, clear tissue edges, and high accuracy of spatial position.