公开(公告)号：US20220008562A1

公开(公告)日：2022-01-13

申请号：US17295647

申请日：2019-11-21

Applicant: BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Stephan HOLZSCHUH ,  Thomas FRENZEL ,  Gregor JOST ,  Jessica LOHRKE ,  Wolfgang EBERT ,  Thomas BRUMBY ,  Wolfgang HALFBRODT

IPC: A61K49/10 ,  A61K49/08 ,  A61K49/12

Abstract: The present disclosure relates to a liquid pharmaceutical formulation comprising a DOSA-derived tetra-chelate of formula (I), in which M is an ion of a paramagnetic metal, preferably a Gd3+ ion, and R1, R2, R3, R4 and R5 are as defined in the claims, in a pharmaceutical acceptable solvent. The present disclosure also relates to a method of preparation of said liquid pharmaceutical formulation and to a method of imaging involving said liquid pharmaceutical formulation.

公开(公告)号：US20210221798A1

公开(公告)日：2021-07-22

申请号：US17218907

申请日：2021-03-31

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Markus BERGER ,  Jessica LOHRKE ,  Christoph-Stephan HILGER ,  Gregor JOST ,  Thomas FRENZEL ,  Olaf PANKNIN ,  Hubertus PIETSCH

IPC: C07D403/14 ,  A61K49/10 ,  C07D257/02

Abstract: The present invention relates to a new class of high relaxivity extracellular gadolinium chelate complexes, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.

公开(公告)号：US20200283420A1

公开(公告)日：2020-09-10

申请号：US16463076

申请日：2017-11-24

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Markus BERGER ,  Jessica LOHRKE ,  Christoph-Stephan HILGER ,  Gregor JOST ,  Thomas FRENZEL ,  Olaf PANKNIN ,  Hubertus PIETSCH

IPC: C07D403/14 ,  A61K49/10 ,  C07D257/02

Abstract: The present invention relates to a new class of high relaxivity extracellular gadolinium chelate complexes, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.

公开(公告)号：US20240182431A1

公开(公告)日：2024-06-06

申请号：US18278750

申请日：2022-03-14

Applicant: Bayer Aktiengesellschaft

Inventor： Thomas BRUMBY ,  Jessica LOHRKE ,  Simon Anthony HERBERT ,  Olaf PANKNIN ,  Thomas FRENZEL ,  Claudia GREEN ,  Gregor JOST ,  Hubertus PIETSCH ,  Markus BERGER ,  Sven WITTROCK

IPC: C07D257/02 ,  A61K49/08 ,  C07F5/00

CPC classification number: C07D257/02 ,  A61K49/085 ,  C07F5/003

Abstract: The present invention relates to a new class of compounds of general formula (I), the Gd3+ chelate complexes thereof, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents. Formula (I)