公开(公告)号：US20210221798A1

公开(公告)日：2021-07-22

申请号：US17218907

申请日：2021-03-31

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Markus BERGER ,  Jessica LOHRKE ,  Christoph-Stephan HILGER ,  Gregor JOST ,  Thomas FRENZEL ,  Olaf PANKNIN ,  Hubertus PIETSCH

IPC: C07D403/14 ,  A61K49/10 ,  C07D257/02

Abstract: The present invention relates to a new class of high relaxivity extracellular gadolinium chelate complexes, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.

公开(公告)号：US20200283420A1

公开(公告)日：2020-09-10

申请号：US16463076

申请日：2017-11-24

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Markus BERGER ,  Jessica LOHRKE ,  Christoph-Stephan HILGER ,  Gregor JOST ,  Thomas FRENZEL ,  Olaf PANKNIN ,  Hubertus PIETSCH

IPC: C07D403/14 ,  A61K49/10 ,  C07D257/02

Abstract: The present invention relates to a new class of high relaxivity extracellular gadolinium chelate complexes, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.

公开(公告)号：US20190350910A1

公开(公告)日：2019-11-21

申请号：US16479461

申请日：2018-01-15

Applicant: Bayer Pharma Aktiengesellschaft ,  Bayer Aktiengesellschaft

Inventor： Ulrich KLAR ,  Rolf BOHLMANN ,  Heike SCHÄCKE ,  Detlev SÜLZLE ,  Stephan MENZ ,  Olaf PANKNIN

IPC: A61K31/437 ,  C07D495/14 ,  C07D471/04 ,  C07D519/00 ,  C07D495/04 ,  C07D513/04 ,  C07D498/08 ,  A61K31/5386 ,  C07D473/34

Abstract: The present invention relates to substituted dihydroimidazopyridinedione compounds of general formula (A) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative, angiogenesis disorders, inflammatory diseases or diseases associated with inflammatory pain, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20170197921A1

公开(公告)日：2017-07-13

申请号：US15118154

申请日：2015-02-10

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Hartmut REHWINKEL ,  Olaf PANKNIN ,  Sven RING ,  Sonja ANLAUF ,  Holger SIEBENEICHER ,  Duy NGUYEN ,  Wolfgang SCHWEDE ,  Marcus BAUSER ,  Katja ZIMMERMANN ,  Stefan KAULFUSS ,  Roland NEUHAUS ,  Paul Matthew BLANEY

IPC: C07D235/30 ,  A61K31/4439 ,  C07D401/12 ,  A61K31/4184 ,  A61K45/06

CPC classification number: C07D235/30 ,  A61K31/4184 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/12

Abstract: The present invention relates to benzimidazol-2-amines of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20180201585A1

公开(公告)日：2018-07-19

申请号：US15744641

申请日：2016-07-12

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Olaf PANKNIN ,  Sven RING ,  Katja ZIMMERMANN ,  Roland NEUHAUS

IPC: C07D235/30 ,  A61K31/4184 ,  A61K45/06 ,  A61P35/00

CPC classification number: C07D235/30 ,  A61K31/4184 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention relates to benzimidazol-2-amines of general formula (I) in which R1, R2, R3, R4, R5, R6 and R7 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20180170882A1

公开(公告)日：2018-06-21

申请号：US15580372

申请日：2016-06-03

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Sven RING ,  Olaf PANKNIN ,  Katja ZIMMERMANN ,  Judith GÜNTHER ,  Lars BÄRFACKER

IPC: C07D235/30 ,  A61K31/4184 ,  A61K45/06

CPC classification number: C07D235/30 ,  A61K31/4184 ,  A61K45/06 ,  C07C229/42 ,  C07C229/60 ,  C07D235/24

Abstract: The present invention relates to benzimidazol-2-amines of general formula (I), in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20170319549A1

公开(公告)日：2017-11-09

申请号：US15520384

申请日：2015-10-21

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Hartmut REHWINKEL ,  Sonja ANLAUF ,  Duy NGUYEN ,  Olaf PANKNIN ,  Marcus BAUSER ,  Katja ZIMMERMANN ,  Stefan KAULFUSS ,  Roland NEUHAUS ,  Paul Matthew BLANEY ,  Gianna TOSCHI

IPC: A61K31/4184 ,  C07D235/30

CPC classification number: A61K31/4184 ,  C07D235/30 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04

Abstract: The present invention relates to benzimidazol-2-amines of general formula (I) in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20170197922A1

公开(公告)日：2017-07-13

申请号：US15118157

申请日：2015-02-10

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Hartmut REHWINKEL ,  Holger SIEBENEICHER ,  Sonja ANLAUF ,  Duy NGUYEN ,  Olaf PANKNIN ,  Sven RING ,  Wolfgang SCHWEDE ,  Marcus BAUSER ,  Katja ZIMMERMANN ,  Stefan KAULFUSS ,  Roland NEUHAUS

IPC: C07D235/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

CPC classification number: C07D235/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: The present invention relates to benzimidazol-2-amines of general formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20210085656A1

公开(公告)日：2021-03-25

申请号：US16983768

申请日：2020-08-03

Applicant: Bayer Pharma Aktiengesellschaft ,  Bayer Aktiengesellschaft

Inventor： Ulrich KLAR ,  Rolf BOHLMANN ,  Heike SCHÄCKE ,  Detlev SÜLZLE ,  Stephan MENZ ,  Olaf PANKNIN

IPC: A61K31/437 ,  A61K31/5386 ,  C07D471/04 ,  C07D473/34 ,  C07D495/04 ,  C07D495/14 ,  C07D498/08 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention relates to substituted dihydroimidazopyridinedione compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative, angiogenesis disorders, inflammatory diseases or diseases associated with inflammatory pain, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20180215717A1

公开(公告)日：2018-08-02

申请号：US15746352

申请日：2016-07-14

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Olaf PANKNIN ,  Ingo HARTUNG ,  Hartmut REHWINKEL ,  Duy NGUYEN ,  Ludwig ZORN ,  Petra HELFRICH ,  Katja ZIMMERMANN ,  Roland NEUHAUS

IPC: C07D235/30 ,  C12P17/10 ,  A61K31/4184 ,  A61K45/06 ,  A61P35/00 ,  C07D471/04 ,  A61K31/437

CPC classification number: C07D235/30 ,  A61K31/4184 ,  A61K31/437 ,  A61K45/06 ,  A61P35/00 ,  C07D471/04 ,  C12P17/10

Abstract: The present invention relates to compounds of general formula (I): in which R1, R2, R3, R4, R6, R7, R8, R9, R10, R11, R12, R13 and X are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.