公开(公告)号：US20220008562A1

公开(公告)日：2022-01-13

申请号：US17295647

申请日：2019-11-21

Applicant: BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Stephan HOLZSCHUH ,  Thomas FRENZEL ,  Gregor JOST ,  Jessica LOHRKE ,  Wolfgang EBERT ,  Thomas BRUMBY ,  Wolfgang HALFBRODT

IPC: A61K49/10 ,  A61K49/08 ,  A61K49/12

Abstract: The present disclosure relates to a liquid pharmaceutical formulation comprising a DOSA-derived tetra-chelate of formula (I), in which M is an ion of a paramagnetic metal, preferably a Gd3+ ion, and R1, R2, R3, R4 and R5 are as defined in the claims, in a pharmaceutical acceptable solvent. The present disclosure also relates to a method of preparation of said liquid pharmaceutical formulation and to a method of imaging involving said liquid pharmaceutical formulation.