公开(公告)号：US12138278B2

公开(公告)日：2024-11-12

申请号：US18639630

申请日：2024-04-18

Applicant: BAUSCH HEALTH IRELAND LIMITED

Inventor： Varsha Bhatt ,  Radhakrishnan Pillai ,  Arturo Angel

IPC: A61K31/7056 ,  A61K8/22 ,  A61K8/34 ,  A61K8/49 ,  A61K8/73 ,  A61K9/00 ,  A61K9/06 ,  A61K31/192 ,  A61K31/327 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61P17/10 ,  A61Q19/00

Abstract: The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.

公开(公告)号：US12128137B2

公开(公告)日：2024-10-29

申请号：US17719278

申请日：2022-04-12

Applicant: BAUSCH HEALTH IRELAND LIMITED

Inventor： Arturo Angel ,  Radhakrishnan Pillai

IPC: A61K9/107 ,  A61K9/00 ,  A61K9/06 ,  A61K31/4436 ,  A61K47/06 ,  A61K47/14 ,  A61K47/32 ,  A61K47/34 ,  A61K47/44 ,  A61P17/00 ,  A61P17/10

CPC classification number: A61K9/107 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/4436 ,  A61K47/06 ,  A61K47/14 ,  A61K47/32 ,  A61K47/34 ,  A61K47/44 ,  A61P17/00 ,  A61P17/10

Abstract: Topical pharmaceutical compositions include tazarotene or a pharmaceutically acceptable salt of tazarotenic acid and an oil-in-water emulsion vehicle that forms a lotion. The compositions are used to treat skin diseases, such as acne vulgaris.

公开(公告)号：US20240325423A1

公开(公告)日：2024-10-03

申请号：US18639619

申请日：2024-04-18

Applicant: BAUSCH HEALTH IRELAND LIMITED

Inventor： Varsha BHATT ,  Radhakrishnan Pillai ,  Arturo Angel

IPC: A61K31/7056 ,  A61K8/22 ,  A61K8/34 ,  A61K8/49 ,  A61K8/73 ,  A61K9/00 ,  A61K9/06 ,  A61K31/192 ,  A61K31/327 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61P17/10 ,  A61Q19/00

CPC classification number: A61K31/7056 ,  A61K8/22 ,  A61K8/345 ,  A61K8/4913 ,  A61K8/731 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/192 ,  A61K31/327 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61P17/10 ,  A61Q19/005

Abstract: The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.

公开(公告)号：US11839656B2

公开(公告)日：2023-12-12

申请号：US17993806

申请日：2022-11-23

Applicant: Bausch Health Ireland Limited

Inventor： Arturo Angel ,  Gordon Dow

IPC: A61K47/14 ,  A61P17/06 ,  A61P9/14 ,  A61P9/06 ,  A61K31/573 ,  A61K31/58 ,  A61K9/06 ,  A61K9/00 ,  A61K9/107 ,  A61K9/127

CPC classification number: A61K47/14 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/107 ,  A61K9/127 ,  A61K31/573 ,  A61K31/58 ,  A61P17/06

Abstract: Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and further comprise a liquid oil component comprising one or more dicarboxylic acid esters and/or monocarboxylic acid esters.

公开(公告)号：US11957753B2

公开(公告)日：2024-04-16

申请号：US15966367

申请日：2018-04-30

Applicant: BAUSCH HEALTH IRELAND LIMITED

Inventor： Arturo Angel ,  Gordon Dow

IPC: A61K47/14 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61K9/127 ,  A61K9/14 ,  A61K31/573 ,  A61K31/58 ,  A61P17/06

CPC classification number: A61K47/14 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/107 ,  A61K9/127 ,  A61K31/573 ,  A61K31/58 ,  A61P17/06

Abstract: Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and further comprise a liquid oil component comprising one or more dicarboxylic acid esters and/or monocarboxylic acid esters.

公开(公告)号：US12133859B2

公开(公告)日：2024-11-05

申请号：US18639619

申请日：2024-04-18

Applicant: BAUSCH HEALTH IRELAND LIMITED

Inventor： Varsha Bhatt ,  Radhakrishnan Pillai ,  Arturo Angel

IPC: A61K31/7056 ,  A61K8/22 ,  A61K8/34 ,  A61K8/49 ,  A61K8/73 ,  A61K9/00 ,  A61K9/06 ,  A61K31/192 ,  A61K31/327 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61P17/10 ,  A61Q19/00

Abstract: The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.

公开(公告)号：US12128059B2

公开(公告)日：2024-10-29

申请号：US17835935

申请日：2022-06-08

Applicant: BAUSCH HEALTH IRELAND LIMITED

Inventor： Varsha Bhatt ,  Radhakrishnan Pillai ,  Arturo Angel

IPC: A61K31/7056 ,  A61K8/22 ,  A61K8/34 ,  A61K8/49 ,  A61K8/73 ,  A61K9/00 ,  A61K9/06 ,  A61K31/192 ,  A61K31/327 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61P17/10 ,  A61Q19/00

CPC classification number: A61K31/7056 ,  A61K8/22 ,  A61K8/345 ,  A61K8/4913 ,  A61K8/731 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/192 ,  A61K31/327 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61P17/10 ,  A61Q19/005

Abstract: The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.

公开(公告)号：US12076403B2

公开(公告)日：2024-09-03

申请号：US17993799

申请日：2022-11-23

Applicant: Bausch Health Ireland Limited

Inventor： Arturo Angel ,  Gordon Dow

IPC: A61K47/14 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61K9/127 ,  A61K9/14 ,  A61K31/573 ,  A61K31/58 ,  A61P17/06

CPC classification number: A61K47/14 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/107 ,  A61K9/127 ,  A61K31/573 ,  A61K31/58 ,  A61P17/06

Abstract: Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and further comprise a liquid oil component comprising one or more dicarboxylic acid esters and/or monocarboxylic acid esters.

公开(公告)号：US11986527B2

公开(公告)日：2024-05-21

申请号：US16174023

申请日：2018-10-29

Applicant: BAUSCH HEALTH IRELAND LIMITED

Inventor： Arturo Angel ,  Gordon Dow

IPC: A61K47/14 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61K9/127 ,  A61K9/14 ,  A61K31/573 ,  A61K31/58 ,  A61P17/06

CPC classification number: A61K47/14 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/107 ,  A61K9/127 ,  A61K31/573 ,  A61K31/58 ,  A61P17/06

Abstract: Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and further comprise a liquid oil component comprising one or more dicarboxylic acid esters and/or monocarboxylic acid esters.

公开(公告)号：US20230000768A1

公开(公告)日：2023-01-05

申请号：US17747938

申请日：2022-05-18

Applicant: BAUSCH HEALTH IRELAND LIMITED

Inventor： Arturo Angel ,  Chandelle Hermes

IPC: A61K9/107 ,  A61K9/00 ,  A61K47/32 ,  A61K9/06 ,  A61K31/4436 ,  A61K31/203 ,  A61K31/573

Abstract: Provided herein are compositions comprising an oil-in-water emulsion, wherein the emulsion comprises a liquid oil component; a cross-linked homopolymer based on acrylic acid and/or a cross-linked copolymer of acrylic acid and acrylic acid esters; and water. In some embodiments, the composition is a vehicle for the delivery of an active agent.