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公开(公告)号：US20230183686A1
公开(公告)日：2023-06-15
申请号：US17933005
申请日：2022-09-16
发明人： Leendert W. Neuteboom , John A. McElver , Rosa De Pinho Barroco , Chris De Wilde , Max Fabian Felle
IPC分类号： C12N15/11 , C12N15/10 , C12N15/70 , C12N15/75 , C12N15/82 , C12N15/85 , C12N15/90 , C12N15/81
CPC分类号： C12N15/11 , C12N15/102 , C12N15/111 , C12N15/70 , C12N15/75 , C12N15/8274 , C12N15/8509 , C12N15/902 , C12N15/81 , C12N2310/20 , C12N15/905 , C12N15/907
摘要： Methods for modification of target nucleic acids. The method involves a construct in which guide RNA is covalently linked to donor RNA (fusion NA) to be introduced into the target nucleic acid by homologous recombination and is based on the introduction of a nuclease, e.g. CRISPR or TALEN, into the cell containing the target nucleic acid. The fusion NA may be introduced as a DNA vector.
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公开(公告)号：US11613761B1
公开(公告)日：2023-03-28
申请号：US15526550
申请日：2015-11-13
发明人： Toralf Senger , Laurent Marty , Irene Kunze , Heiko Haertel , Steven Craig Bremmer , Steven D. Breazeale , Joerg Bauer , Patricia Vrinten , Sten Stymne , Jenny Lindberg Yilmaz , John A. McElver , Dietrich Rein , Carl Andre
摘要： T-DNA for expression of a target gene in a plant, wherein the T-DNA comprises a left and a right border element and at least one expression cassette comprising a promoter, operatively linked thereto a target gene, and downstream thereof a terminator, wherein the length of the T-DNA, measured from left to right border element and comprising the target gene, has a length of at least 30000 bp.
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公开(公告)号：US11608499B2
公开(公告)日：2023-03-21
申请号：US16097300
申请日：2017-04-20
发明人： Leendert W. Neuteboom , John A. McElver , Rosa De Pinho Barroco , Chris De Wilde , Max Fabian Felle
IPC分类号： C12N15/11 , C12N15/10 , C12N15/70 , C12N15/75 , C12N15/82 , C12N15/85 , C12N15/90 , C12N15/81
摘要： Methods for modification of target nucleic acids. The method involves a construct in which guide RNA is covalently linked to donor RNA (fusion NA) to be introduced into the target nucleic acid by homologous recombination and is based on the introduction of a nuclease, e.g. CRISPR or TALEN, into the cell containing the target nucleic acid. The fusion NA may be introduced as a DNA vector.
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公开(公告)号：US20230293615A1
公开(公告)日：2023-09-21
申请号：US18162300
申请日：2023-01-31
发明人： Toralf Senger , Laurent Marty , Irene Kunze , Heiko Haertel , Steven Craig Bremmer , Steven D. Breazeale , Joerg Bauer , Patricia Vrinten , Sten Stymne , Jenny Lindberg Yilmaz , John A. McElver , Dietrich Rein , Carl Andre
IPC分类号： A61K36/31 , C12Q1/6895
CPC分类号： A61K36/31 , C12Q1/6895 , C12N15/8247
摘要： T-DNA for expression of a target gene in a plant, wherein the T-DNA comprises a left and a right border element and at least one expression cassette comprising a promoter, operatively linked thereto a target gene, and downstream thereof a terminator, wherein the length of the T-DNA, measured from left to right border element and comprising the target gene, has a length of at least 30000 bp.
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公开(公告)号：US20230024869A1
公开(公告)日：2023-01-26
申请号：US17933003
申请日：2022-09-16
发明人： Leendert W. NEUTEBOOM , John A. McElver , Rosa De Pinho Barroco , Chris De Wilde , Max Fabian Felle
IPC分类号： C12N15/11 , C12N15/70 , C12N15/75 , C12N15/81 , C12N15/82 , C12N15/85 , C12N15/90 , C12N15/10
摘要： Methods for modification of target nucleic acids. The method involves a construct in which guide RNA is covalently linked to donor RNA (fusion NA) to be introduced into the target nucleic acid by homologous recombination and is based on the introduction of a nuclease, e.g. CRISPR or TALEN, into the cell containing the target nucleic acid. The fusion NA may be introduced as a DNA vector.
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公开(公告)号：US20190309290A1
公开(公告)日：2019-10-10
申请号：US16097300
申请日：2017-04-20
发明人： Leendert W. Neuteboom , John A. McElver , Rosa De Pinho Barroco , Chris De Wilde , Max Fabian Felle
摘要： Methods for modification of target nucleic acids. The method involves a construct in which guide RNA is covalently linked to donor RNA (fusion NA) to be introduced into the target nucleic acid by homologous recombination and is based on the introduction of a nuclease, e.g. CRISPR or TALEN, into the cell containing the target nucleic acid. The fusion NA may be introduced as a DNA vector.
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