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公开(公告)号：US20210189335A1
公开(公告)日：2021-06-24
申请号：US16090590
申请日：2017-03-30
发明人： Erik Michael WHITELEY , Uzma SHOUKAT-MUMTAZ , Rashi SRIVASTAVA , Nathan Charles MANLEY , Casey Christopher CASE
摘要： Compositions comprising a population of oligodendrocyte progenitor cells (OPCs), as well as methods of making and using the same, are provided. In one aspect, a container comprising a composition, where the composition comprises a population of cells comprising a plurality of OPCs, and where the population of cells comprises less than 15% undesirable cell types is provided. In another aspect, the population of cells comprises less than 15% undesirable epithelial lineage cells. In yet another aspect, the population of cells comprises less than 2% K7 positive cells. In an aspect, a population of cells comprising a plurality of oligodendrocyte progenitor cells is capable of forming less than one epithelial cyst per 100,000 cells in a cyst assay is provided. An even further aspect of the present disclosure is a container comprising a composition, where the composition comprising a plurality of oligodendrocyte progenitor cells is useful in treating treat stroke, spinal cord injury, and multiple sclerosis.
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公开(公告)号：US20240166994A1
公开(公告)日：2024-05-23
申请号：US18424325
申请日：2024-01-26
发明人： Erik Michael WHITELEY , Uzma SHOUKAT-MUMTAZ , Rashi SRIVASTAVA , Nathan Charles MANLEY , Casey Christopher CASE
CPC分类号： C12N5/0622 , A61K35/30
摘要： Compositions comprising a population of oligodendrocyte progenitor cells (OPCs), as well as methods of making and using the same, are provided. In one aspect, a container comprising a composition, where the composition comprises a population of cells comprising a plurality of OPCs, and where the population of cells comprises less than 15% undesirable cell types is provided. In another aspect, the population of cells comprises less than 15% undesirable epithelial lineage cells. In yet another aspect, the population of cells comprises less than 2% K7 positive cells. In an aspect, a population of cells comprising a plurality of oligodendrocyte progenitor cells is capable of forming less than one epithelial cyst per 100,000 cells in a cyst assay is provided. An even further aspect of the present disclosure is a container comprising a composition, where the composition comprising a plurality of oligodendrocyte progenitor cells is useful in treating treat stroke, spinal cord injury, and multiple sclerosis.
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