公开(公告)号：US20150299182A1

公开(公告)日：2015-10-22

申请号：US14441133

申请日：2013-11-08

Applicant: Array BioPharma Inc. ,  Amgen Inc.

Inventor： Sylvie Asselin ,  Lisa Brett ,  Ying Chen ,  Donald T. Corson ,  Andrew Cosbie ,  Robert Farrell ,  Indrani W. Gunawardana ,  Jinkun Huang ,  Jonathan W. Lane ,  Dennis Lei ,  Christopher M. Lindemann ,  Van Luu ,  Coralee G. Mannila ,  Robert Milburn ,  Henry Morrison ,  Helming Tan ,  Jason Tedrow ,  Daniel J. Watson

IPC: C07D417/14

CPC classification number: C07D417/14 ,  C07B2200/13

Abstract: The present invention relates to crystalline polymorph forms of (1S)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol, to pharmaceutical compositions comprising such crystalline polymorph forms, and to processes for preparing them. The invention further relates to methods of treatment of diabetes related disorders comprising administering such solid-state forms or compositions thereof to a subject, and to use of such crystalline polymorph forms in the manufacture of medicaments.

Abstract translation: 本发明涉及（1S）-1- [5 - （{3 - [（2-甲基吡啶-3-基）氧基] -5-（吡啶-2-基硫烷基）吡啶-2-基} 氨基）-1,2,4-噻二唑-3-基]乙烷-1,2-二醇，包括这种结晶多晶型物的药物组合物及其制备方法。 本发明还涉及治疗糖尿病相关病症的方法，包括将这种固态形式或其组合物施用于受试者，以及在制备药物中使用这种结晶多晶型物。

公开(公告)号：US11472773B2

公开(公告)日：2022-10-18

申请号：US16920144

申请日：2020-07-02

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Sheng Cui ,  Henry Morrison ,  Karthik Nagapudi ,  Shawn D. Walker ,  Charles Bernard ,  Karl Bennett Hansen ,  Neil Fred Langille ,  Alan Martin Allgeier ,  Steven Mennen ,  Jacqueline C. S. Woo ,  Bradley Paul Morgan ,  Alex Muci

IPC: A61P9/00 ,  A61P9/04 ,  C07D213/75 ,  A61K47/38 ,  A61K31/496 ,  A61K9/20

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

公开(公告)号：US11465969B2

公开(公告)日：2022-10-11

申请号：US17263224

申请日：2019-08-16

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Henry Morrison ,  Sheng Cui ,  Kyle Quasdorf ,  Evelyn Yanez ,  Bin Peter Quan ,  Ron C. Kelly ,  Sebastien Caille ,  Lingyun Xiao ,  David Pearson ,  Jaclyn Raeburn ,  Ailsa Golightly ,  Bradley Morgan ,  Matthew Peterson ,  Alex Eberlin ,  Alexander Oblezov

IPC: C07D213/75

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

公开(公告)号：US20200079736A1

公开(公告)日：2020-03-12

申请号：US16684216

申请日：2019-11-14

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Sheng Cui ,  Henry Morrison ,  Karthik Nagapudi ,  Shawn Walker ,  Charles Bernard ,  Karl Bennett Hansen ,  Neil Fred Langille ,  Alan Martin Allgeier ,  Steven Mennen ,  Jacqueline C.S. Woo ,  Bradley Paul Morgan ,  Alex Muci

IPC: C07D213/75 ,  A61K47/38 ,  A61K31/496 ,  A61K9/20

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

公开(公告)号：US11926592B2

公开(公告)日：2024-03-12

申请号：US17929645

申请日：2022-09-02

Applicant: Amgen Inc.

Inventor： Henry Morrison ,  Sheng Cui ,  Kyle Quasdorf ,  Evelyn Yanez ,  Bin Peter Quan ,  Ron C. Kelly ,  Sebastien Caille ,  Lingyun Xiao ,  David Pearson ,  Jaclyn Raeburn ,  Alisa Golightly

IPC: C07D213/75

CPC classification number: C07D213/75 ,  C07B2200/13

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

公开(公告)号：US20200331859A1

公开(公告)日：2020-10-22

申请号：US16920155

申请日：2020-07-02

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Sheng Cui ,  Henry Morrison ,  Karthik Nagapudi ,  Shawn Walker ,  Charles Bernard ,  Karl Bennett Hansen ,  Neil Fred Langille ,  Alan Martin Allgeier ,  Steven Mennen ,  Jacqueline C.S. Woo ,  Bradley Paul Morgan ,  Alex Muci

IPC: C07D213/75 ,  A61K9/20 ,  A61K31/496 ,  A61K47/38

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

公开(公告)号：US20160016906A1

公开(公告)日：2016-01-21

申请号：US14773436

申请日：2014-03-14

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Sheng Cui ,  Henry Morrison ,  Karthik Nagapudi ,  Shawn Walker ,  Charles Bernard ,  Karl Bennett Hansen ,  Neil Fred Langille ,  Alan Martin Allgeier ,  Steven Mennen ,  Jacqueline Woo ,  Bradley Paul Morgan ,  Alex Muci

IPC: C07D213/75

CPC classification number: C07D213/75 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/496 ,  A61K47/38

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use. Omecamtiv mecarbil (AMG 423, CK-1827452), having the structure:

Abstract translation: 本发明提供了奥美康米卡非二盐酸盐形式，其组合物和药物制剂及其制备和使用方法。 Omecamtiv mecarbil（AMG 423，CK-1827452），具有以下结构：

公开(公告)号：US20210221771A1

公开(公告)日：2021-07-22

申请号：US17263224

申请日：2019-08-16

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Henry Morrison ,  Sheng Cui ,  Kyle Quasdorf ,  Evelyn Yanez ,  Bin Peter Quan ,  Ron C. Kelly ,  Sebastien Caille ,  Lingyun Xiao ,  David Pearson ,  Jaclyn Raeburn ,  Ailsa Golightly ,  Bradley Morgan ,  Matthew Peterson ,  Alex Eberlin ,  Alexander Oblezov

IPC: C07D213/75

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

公开(公告)号：US20180312469A1

公开(公告)日：2018-11-01

申请号：US15963529

申请日：2018-04-26

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Sheng Cui ,  Henry Morrison ,  Karthik Nagapudi ,  Shawn Walker ,  Charles Bernard ,  Karl Bennett Hansen ,  Neil Fred Langille ,  Alan Martin Allgeier ,  Steven Mennen ,  Jacqueline Woo ,  Bradley Paul Morgan ,  Alex Muci

IPC: C07D213/75 ,  A61K9/20 ,  A61K31/496 ,  A61K47/38

CPC classification number: C07D213/75 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/496 ,  A61K47/38

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

公开(公告)号：US20230312602A1

公开(公告)日：2023-10-05

申请号：US18296215

申请日：2023-04-05

Applicant: AMGEN INC.

Inventor： Henry Morrison ,  Jason S. Tedrow ,  Stephan D. Parent ,  Courtney Johnson ,  Travis Houston ,  Melanie Bevill

IPC: C07D513/08

CPC classification number: C07D513/08 ,  C07B2200/13

Abstract: Disclosed herein are salt and solvate forms of. (1S,3′R,6′R,7′S,8′E,11′S,12′R)-6-chloro-7′-methoxy-11′,12′-dimethyl-3,4-dihydro-2H,15′H-spiro[naphthalene-1,22′-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.03,6.019,24]pentacosa[8,16,18,24]tetraen]-15′-one 13′,13′-dioxide (AMG 176):




such as crystalline salt and solvate forms thereof. Also disclosed are methods of making the salt and solvate forms, and methods of treating diseases and disorders with the salt and solvate forms.