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公开(公告)号：US11465969B2
公开(公告)日：2022-10-11
申请号：US17263224
申请日：2019-08-16
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Henry Morrison , Sheng Cui , Kyle Quasdorf , Evelyn Yanez , Bin Peter Quan , Ron C. Kelly , Sebastien Caille , Lingyun Xiao , David Pearson , Jaclyn Raeburn , Ailsa Golightly , Bradley Morgan , Matthew Peterson , Alex Eberlin , Alexander Oblezov
IPC: C07D213/75
Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
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公开(公告)号：US20200308143A1
公开(公告)日：2020-10-01
申请号：US16607940
申请日：2018-06-29
Applicant: AMGEN INC.
Inventor： Sebastien Caille , Kyle Quasdorf , Philipp Roosen , Xianqing Shi , Andrew Cosbie , Fang Wang , Zufan Wu , Archana Neergunda , Bin Peter Quan , Lianxiu Guan
IPC: C07D401/12 , C07D241/04
Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (I)
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公开(公告)号：US20210347743A1
公开(公告)日：2021-11-11
申请号：US17272031
申请日：2019-08-30
Applicant: Amgen, Inc.
Inventor： Sebastien Caille , Michael Corbett , Austin Smith
IPC: C07D263/14 , C07D211/76
Abstract: The present invention provides commercial processes for preparing 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3- yl)acetic acid as well as intermediates thereof.
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公开(公告)号：US09801867B2
公开(公告)日：2017-10-31
申请号：US15175824
申请日：2016-06-07
Applicant: AMGEN INC.
Inventor： Matthew Bio , Sebastien Caille , Brian Cochran , Yuanqing Fang , Brian M. Fox , Brian S. Lucas , Lawrence R. McGee , Filisaty Vounatsos , Sean H. Wiedemann , Sarah Wortman
IPC: C07D211/76 , A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07D498/04 , C07C309/35
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
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公开(公告)号：US09623018B2
公开(公告)日：2017-04-18
申请号：US15175805
申请日：2016-06-07
Applicant: AMGEN INC.
Inventor： Matthew Bio , Sebastien Caille , Yuanqing Fang , Brian M. Fox , Brian S. Lucas , Lawrence R. McGee , Sean H. Wiedemann
IPC: C07D498/04 , A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07D211/76 , C07C309/35
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
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Patent Agency Ranking
公开(公告)号：US11753394B2
公开(公告)日：2023-09-12
申请号：US17324867
申请日：2021-05-19
Applicant: AMGEN INC.
Inventor： Sebastien Caille , Kyle Quasdorf , Philipp C. Roosen , Xianqing Shi , Andrew Cosbie , Fang Wang , Zufan Wu , Archana Neergunda , Bin Peter Quan , Lianxiu Guan
IPC: C07D401/12 , C07D241/04
CPC classification number: C07D401/12 , C07D241/04
Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
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公开(公告)号：US11753386B2
公开(公告)日：2023-09-12
申请号：US17272031
申请日：2019-08-30
Applicant: Amgen, Inc.
Inventor： Sebastien Caille , Michael Corbett , Austin Smith
IPC: C07D263/14 , C07D211/76
CPC classification number: C07D263/14 , C07D211/76 , C07B2200/13
Abstract: The present invention provides commercial processes for preparing 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates thereof.
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公开(公告)号：US20210371397A1
公开(公告)日：2021-12-02
申请号：US17324867
申请日：2021-05-19
Applicant: AMGEN INC.
Inventor： Sebastien Caille , Kyle Quasdorf , Philipp C. Roosen , Xianqing Shi , Andrew Cosbie , Fang Wang , Zufan Wu , Archana Neergunda , Bin Peter Quan , Lianxiu Guan
IPC: C07D401/12 , C07D241/04
Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
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公开(公告)号：US20210221771A1
公开(公告)日：2021-07-22
申请号：US17263224
申请日：2019-08-16
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Henry Morrison , Sheng Cui , Kyle Quasdorf , Evelyn Yanez , Bin Peter Quan , Ron C. Kelly , Sebastien Caille , Lingyun Xiao , David Pearson , Jaclyn Raeburn , Ailsa Golightly , Bradley Morgan , Matthew Peterson , Alex Eberlin , Alexander Oblezov
IPC: C07D213/75
Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
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公开(公告)号：US11040956B2
公开(公告)日：2021-06-22
申请号：US16607940
申请日：2018-06-29
Applicant: AMGEN INC.
Inventor： Sebastien Caille , Kyle Quasdorf , Philipp Roosen , Xianqing Shi , Andrew Cosbie , Fang Wang , Zufan Wu , Archana Neergunda , Bin Peter Quan , Lianxiu Guan
IPC: C07D295/205 , C07D213/75 , C07D401/12 , C07D241/04
Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (I)
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