公开(公告)号：US20240016899A1

公开(公告)日：2024-01-18

申请号：US18476273

申请日：2023-09-27

Applicant: Amryt Endo, Inc.

Inventor： Roni MAMLUK ,  Gary PATOU ,  Dana GELBAUM ,  Asi HAVIV

IPC: A61K38/31 ,  A61P1/16 ,  A61P1/12 ,  A61P13/12 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K38/31 ,  A61P1/16 ,  A61P1/12 ,  A61P13/12 ,  A61K9/0053 ,  A61K45/06

Abstract: The present invention relates to oral therapy of a subject suffering from disease e.g. polycystic disease e.g. polycystic kidney disease or polycystic liver disease or PCOS or hypotension especially neurogenic orthostatic hypotension and postprandial hypotension, or intractable diarrhea or neuroendocrine tumors or carcinoid syndrome. The method of treatment comprises oral administration to the subject of a therapeutically effective amount of an oral somatostatin receptor ligand (SRL) e.g. oral octreotide. Combination therapy of oral SRLs with other drugs is also envisaged, e.g. octreotide in combination with a therapeutically effective amount of a second therapeutic agent and optionally in combination with a therapeutically effective amount of a third therapeutic agent.

公开(公告)号：US20250000933A1

公开(公告)日：2025-01-02

申请号：US18429227

申请日：2024-01-31

Applicant: Amryt Endo, Inc.

Inventor： Gary PATOU

IPC: A61K38/095 ,  A61K9/28 ,  A61K9/48 ,  A61K31/573 ,  A61K45/06 ,  A61P1/16 ,  A61P9/02 ,  A61P9/12

Abstract: Methods are disclosed of treating or preventing hypotension (e.g., neurogenic orthostatic hypotension or postprandial hypotension) or portal hypertension (e.g., bleeding esophageal varices associated with portal hypertension) or ascites (e.g., ascites associated with liver cirrhosis), by oral administration to affected subjects of compositions comprising a therapeutically effective amount of terlipressin or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230173034A1

公开(公告)日：2023-06-08

申请号：US18162349

申请日：2023-01-31

Applicant: Amryt Endo, Inc.

Inventor： Roni MAMLUK ,  Gary PATOU ,  Dana GELBAUM ,  Asi HAVIV

IPC: A61K38/31 ,  A61P1/16 ,  A61P1/12 ,  A61P13/12 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K38/31 ,  A61P1/16 ,  A61P1/12 ,  A61P13/12 ,  A61K9/0053 ,  A61K45/06

Abstract: The present invention relates to oral therapy of a subject suffering from disease e.g. polycystic disease e.g. polycystic kidney disease or polycystic liver disease or PCOS or hypotension especially neurogenic orthostatic hypotension and postprandial hypotension, or intractable diarrhea or neuroendocrine tumors or carcinoid syndrome. The method of treatment comprises oral administration to the subject of a therapeutically effective amount of an oral somatostatin receptor ligand (SRL) e.g. oral octreotide. Combination therapy of oral SRLs with other drugs is also envisaged, e.g. octreotide in combination with a therapeutically effective amount of a second therapeutic agent and optionally in combination with a therapeutically effective amount of a third therapeutic agent.