公开(公告)号：US20110274661A1

公开(公告)日：2011-11-10

申请号：US13058780

申请日：2009-08-07

申请人： Alice P. Poon ,  Ralph R. Weichselbaum ,  Bernard Roizman

发明人： Alice P. Poon ,  Ralph R. Weichselbaum ,  Bernard Roizman

IPC分类号： A61K35/76 ,  A61M37/00 ,  A61P19/02 ,  A61P27/02 ,  C12N7/04 ,  A61P35/00

CPC分类号： C07K14/005 ,  A61K35/763 ,  A61K48/0058 ,  C12N7/00 ,  C12N9/1205 ,  C12N15/85 ,  C12N15/86 ,  C12N2710/16622 ,  C12N2710/16632 ,  C12N2710/16643 ,  C12N2710/16661 ,  C12N2710/16662 ,  C12N2830/002 ,  C12N2830/60

摘要： The disclosure provides materials and methods for the treatment of cells exhibiting a cell proliferative disorder with a herpes simplex virus having a deficiency in the expression of active ICP34.5 and comprising an expression control element effective in modulating at least one component of the MEK pathway to ensure that infected cells are MEK+. Cell proliferative diseases, disorders or conditions, such as cancers, rheumatoid arthritis and macular degeneration, are amenable to treatment using these HSVs. Further provided are methods for preventing such cell proliferative disorders by administering the HSVs as well as methods for ameliorating a symptom associated with a cell proliferative disorder by administering such HSVs.

摘要翻译： 本公开提供用于治疗具有细胞增殖性病症的细胞的材料和方法，所述单纯疱疹病毒具有活性ICP34.5的表达缺陷，并且包含有效调节至少一种MEK途径成分的表达控制元件， 确保受感染的细胞是MEK +。 细胞增殖性疾病，疾病或病症，如癌症，类风湿关节炎和黄斑变性，适用于使用这些HSV的治疗。 还提供了通过施用HSV来预防这种细胞增殖性疾病的方法以及通过施用这种HSV来改善与细胞增殖性病症相关的症状的方法。