公开(公告)号：US20200061080A1

公开(公告)日：2020-02-27

申请号：US16436435

申请日：2019-06-10

Applicant: Agile Therapeutics, Inc.

Inventor： Thomas M. Rossi ,  Marie Foegh ,  Agis Kydonieus

IPC: A61K31/567 ,  A61K9/70 ,  A61K31/535 ,  A61K31/56 ,  A61K31/565 ,  A61K9/00

Abstract: Dosing regimens for transdermal delivery of hormones comprising a variable treatment cycle and a fixed rest interval are disclosed.

公开(公告)号：US20180104258A1

公开(公告)日：2018-04-19

申请号：US15705039

申请日：2017-09-14

Applicant: Agile Therapeutics, Inc.

Inventor： Thomas M. Rossi ,  Marie Foegh ,  Agis Kydonieus

IPC: A61K31/57 ,  A61K9/70 ,  A61K31/565 ,  A61K31/566

CPC classification number: A61K31/57 ,  A61K9/7023 ,  A61K9/7038 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/565 ,  A61K31/566 ,  A61K2300/00

Abstract: Dosing regimens for transdermal delivery of hormones comprising a 28 day treatment cycle with a fixed treatment interval and a fixed rest interval are disclosed.

公开(公告)号：US20180104193A1

公开(公告)日：2018-04-19

申请号：US15705093

申请日：2017-09-14

Applicant: Agile Therapeutics, Inc.

Inventor： Thomas M. Rossi ,  Marie Foegh ,  Agis Kydonieus

IPC: A61K9/70 ,  A61K31/569 ,  A61K45/06 ,  A61K31/57 ,  A61K31/567

CPC classification number: A61K9/703 ,  A61K9/7038 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/567 ,  A61K31/569 ,  A61K31/57 ,  A61K45/06 ,  A61K2300/00

Abstract: Dosing regimens for transdermal delivery of hormones comprising a five week treatment cycle with a fixed treatment interval and a fixed rest interval.

公开(公告)号：US09775848B2

公开(公告)日：2017-10-03

申请号：US14925207

申请日：2015-10-28

Applicant: Agile Therapeutics, Inc.

Inventor： Thomas M. Rossi ,  Marie Foegh ,  Agis Kydonieus

IPC: A61K31/57 ,  A61K31/565 ,  A61K31/566 ,  A61K9/70 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24

CPC classification number: A61K31/57 ,  A61K9/7023 ,  A61K9/7038 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/565 ,  A61K31/566 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K2300/00

Abstract: Dosing regimen for transdermal delivery of hormones comprising a monthly treatment cycle with a fixed treatment interval and a variable rest interval.

公开(公告)号：US20180325916A1

公开(公告)日：2018-11-15

申请号：US16045338

申请日：2018-07-25

Applicant: Agile Therapeutics, Inc.

Inventor： Charles G. ARNOLD ,  Agis Kydonieus ,  Thomas M. Rossi ,  Alfred F. Altomari

IPC: A61K31/567 ,  A61K47/20 ,  A61K47/32 ,  A61K31/57 ,  A61K47/12 ,  A61K9/00 ,  A61K9/70

CPC classification number: A61K31/567 ,  A61K9/0014 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/57 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: A composition for transdermal delivery of a progestin for progestin hormone therapy is disclosed. Also disclosed is a transdermal delivery device comprising the composition. For progestin-only hormone therapy, the composition contains an anti-oxidant and does not contain an estrogen. For therapy involving a progestin and an estrogen, the composition contains the progestin, the estrogen and an additional anti-oxidant. Methods of improving the stability of progestin-containing compositions comprising oxidative agents are also disclosed. The methods comprise including one or more anti-oxidants in the compositions.

公开(公告)号：US09782419B2

公开(公告)日：2017-10-10

申请号：US14925223

申请日：2015-10-28

Applicant: Agile Therapeutics, Inc.

Inventor： Thomas M. Rossi ,  Marie Foegh ,  Agis Kydonieus

IPC: A61K31/57 ,  A61K31/565 ,  A61K31/566 ,  A61K9/70 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K31/567 ,  A61K31/535 ,  A61K31/56 ,  A61K9/00

CPC classification number: A61K31/567 ,  A61K9/0014 ,  A61K9/7038 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/535 ,  A61K31/56 ,  A61K31/565 ,  A61K2300/00

Abstract: Dosing regimen for transdermal delivery of hormones comprising a variable treatment cycle and a variable rest interval.

公开(公告)号：US12070520B2

公开(公告)日：2024-08-27

申请号：US17073510

申请日：2020-10-19

Applicant: Agile Therapeutics, Inc.

Inventor： Agis Kydonieus ,  Robert G. Conway ,  Thomas M. Rossi

IPC: A61K9/70 ,  A61K31/56 ,  A61K31/57

CPC classification number: A61K9/7084 ,  A61K9/7061 ,  A61K31/56 ,  A61K31/57 ,  A61K31/56 ,  A61K2300/00 ,  A61K31/57 ,  A61K2300/00

Abstract: A transdermal drug delivery device is disclosed. Over an extended wear period, the device causes cumulative moderate irritation plus significant irritation of less than 5% and/or achieves a meaningful degree of detachment over a seven day period of less than 20%.

公开(公告)号：US20210023092A1

公开(公告)日：2021-01-28

申请号：US17069758

申请日：2020-10-13

Applicant: Agile Therapeutics, Inc.

Inventor： Thomas M. ROSSI ,  Marie Foegh ,  Agis Kydonieus

IPC: A61K31/567 ,  A61K9/70 ,  A61K31/535 ,  A61K31/56 ,  A61K31/565 ,  A61K9/00

Abstract: Dosing regimens for transdermal delivery of hormones comprising a variable treatment cycle and a fixed rest interval are disclosed.

公开(公告)号：US20180104256A1

公开(公告)日：2018-04-19

申请号：US15705080

申请日：2017-09-14

Applicant: Agile Therapeutics, Inc.

Inventor： Thomas M. Rossi ,  Marie Foegh ,  Agis Kydonieus

IPC: A61K31/567 ,  A61K31/535 ,  A61K9/70 ,  A61K9/00 ,  A61K31/56 ,  A61K31/565

CPC classification number: A61K31/567 ,  A61K9/0014 ,  A61K9/7038 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/535 ,  A61K31/56 ,  A61K31/565 ,  A61K2300/00

Abstract: Dosing regimens for transdermal delivery of hormones comprising a variable treatment cycle and a fixed rest interval are disclosed.

公开(公告)号：US20180078493A1

公开(公告)日：2018-03-22

申请号：US15668505

申请日：2017-08-03

Applicant: Agile Therapeutics, Inc.

Inventor： Agis Kydonieus ,  Thomas M. Rossi ,  Charles G. Arnold ,  Ajay K. Banga ,  Vishal Sachdeva

IPC: A61K9/00 ,  A61K31/565 ,  A61K9/70 ,  A61K31/567

CPC classification number: A61K9/0014 ,  A61K9/7053 ,  A61K31/565 ,  A61K31/567 ,  A61K2300/00

Abstract: Compositions and devices for transdermal hormone delivery are disclosed. The compositions and devices include desogestrel and enable delivery of effective amounts of progestin without the use of skin permeation enhancers.