公开(公告)号：US20150086512A1

公开(公告)日：2015-03-26

申请号：US14254833

申请日：2014-04-16

Applicant: Advanced Cell Technology, Inc.

Inventor： Christopher Malcuit ,  Linda Lemieux ,  William Holmes ,  Pedro Huertas ,  Lucy Vilner

IPC: C12N5/079 ,  A61K35/30

CPC classification number: C12N5/0621 ,  A61K35/12 ,  A61K35/30 ,  C12N2501/10 ,  C12N2501/734 ,  C12N2506/02 ,  C12N2509/00 ,  C12N2533/54

Abstract: The present invention provides improved methods for producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described herein are useful for treating retinal degenerative diseases.

Abstract translation: 本发明提供了用于从人胚胎干细胞或其他人多能干细胞产生RPE细胞的改进方法。 本发明还涉及源自人胚胎干细胞或其他人多能或多能干细胞的人视网膜色素上皮细胞。 衍生自胚胎干细胞的hRPE细胞与成体和胎儿衍生的RPE细胞分子不同，并且也不同于胚胎干细胞。 本文所述的hRPE细胞可用于治疗视网膜退行性疾病。