公开(公告)号：US20230084687A1

公开(公告)日：2023-03-16

申请号：US17790183

申请日：2020-12-24

申请人： Adaptive Phage Therapeutics, Inc.

发明人： Rob Cohen ,  Greg Merril

IPC分类号： G16H70/60 ,  G16H40/20 ,  G16H20/10

摘要： A method of selecting a phage formulation is described wherein the method comprises storing bacterial infection/contamination data at one or more treatment locations in a spatio-temporal infection database, the database comprising at least one of the following data fields: (1) a clinical indication, (2) a bacteria identification, (3) a clinical outcome, (4) a phage resistance status, (5) a phage susceptibility profile, (6) an antibiotic susceptibility profile, and/or (7) a lab test result relating to any one of (1)-(6); identifying one or more phage suitable for inclusion in the phage formulation by analyzing the data fields of (1)-(7) in the database to identify to one or more infections associated with a treatment location during a historical time period based at least on one or more of a frequency of infections/contamination, a geographic clustering of infections/contamination, and/or phage usage data; and generating a selected list of phage to be included in the phage formulation. Uses of formulations are also described.

公开(公告)号：US20230046598A1

公开(公告)日：2023-02-16

申请号：US17789862

申请日：2020-12-23

申请人： Adaptive Phage Therapeutics, Inc.

发明人： Rob Cohen ,  Greg Merril ,  Miguel Barreto-Sanz ,  Priyesh Prateek Agrawal

IPC分类号： G06N20/00

摘要： A computer implemented method of generating a machine learning model for interpreting host phage response data comprising receiving datasets and labels for a host phage response, training a machine learning model and using this model to estimate the efficacy of a test phage in inhibiting growth of a test bacteria.

公开(公告)号：US20240108551A1

公开(公告)日：2024-04-04

申请号：US18535422

申请日：2023-12-11

申请人： Adaptive Phage Therapeutics, Inc.

发明人： Carl Merril ,  Greg Merril

IPC分类号： A61J7/00 ,  A61J1/06 ,  A61K35/76 ,  B65G1/137 ,  G16H10/40 ,  G16H20/13 ,  G16H40/20

CPC分类号： A61J7/0076 ,  A61J1/06 ,  A61K35/76 ,  B65G1/1371 ,  G16H10/40 ,  G16H20/13 ,  G16H40/20 ,  A61J2200/70 ,  A61J2205/10 ,  A61J2205/60 ,  B65G61/00

摘要： A phage dispensing system comprises a user interface, a phage treatment computing system, a phage laboratory, and a phage dispensing apparatus, including a dispensing kiosk. The user interface allows a treating physician to request testing of a patient sample by the phage laboratory to identify a phage mixture treatment. The phage computing system arranges shipping of the sample and provision of the identified phage mixture treatment to a dispensing apparatus located near the patient. The dispensing apparatus has a stock of phage vials which are used to prepare and dispense doses of the identified phage mixture treatment.

公开(公告)号：US11911345B2

公开(公告)日：2024-02-27

申请号：US16896718

申请日：2018-12-10

申请人： Adaptive Phage Therapeutics, Inc.

发明人： Carl Merril ,  Greg Merril

IPC分类号： A61J7/00 ,  G16H20/13 ,  G16H40/20 ,  G16H10/40 ,  A61J1/06 ,  A61K35/76 ,  B65G1/137 ,  B65G61/00

CPC分类号： A61J7/0076 ,  A61J1/06 ,  A61K35/76 ,  B65G1/1371 ,  G16H10/40 ,  G16H20/13 ,  G16H40/20 ,  A61J2200/70 ,  A61J2205/10 ,  A61J2205/60 ,  B65G61/00

摘要： A phage dispensing system comprises a user interface, a phage treatment computing system, a phage laboratory, and a phage dispensing apparatus, including a dispensing kiosk. The user interface allows a treating physician to request testing of a patient sample by the phage laboratory to identify a phage mixture treatment. The phage computing system arranges shipping of the sample and provision of the identified phage mixture treatment to a dispensing apparatus located near the patient. The dispensing apparatus has a stock of phage vials which are used to prepare and dispense doses of the identified phage mixture treatment.

公开(公告)号：US20200375850A1

公开(公告)日：2020-12-03

申请号：US16896718

申请日：2018-12-10

申请人： Adaptive Phage Therapeutics, Inc.

发明人： Carl Merril ,  Greg Merril

IPC分类号： A61J7/00 ,  A61K35/76 ,  A61J1/06 ,  B65G1/137 ,  G16H10/40 ,  G16H20/13 ,  G16H40/20

摘要： A phage dispensing system comprises a user interface, a phage treatment computing system, a phage laboratory, and a phage dispensing apparatus, including a dispensing kiosk. The user interface allows a treating physician to request testing of a patient sample by the phage laboratory to identify a phage mixture treatment. The phage computing system arranges shipping of the sample and provision of the identified phage mixture treatment to a dispensing apparatus located near the patient. The dispensing apparatus has a stock of phage vials which are used to prepare and dispense doses of the identified phage mixture treatment.