- 专利标题: SYSTEM AND METHOD TO SELECT PHAGE THERAPY BASED ON TIME AND LOCATION
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申请号: US17790183申请日: 2020-12-24
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公开(公告)号: US20230084687A1公开(公告)日: 2023-03-16
- 发明人: Rob Cohen , Greg Merril
- 申请人: Adaptive Phage Therapeutics, Inc.
- 申请人地址: US MD Gaithersburg
- 专利权人: Adaptive Phage Therapeutics, Inc.
- 当前专利权人: Adaptive Phage Therapeutics, Inc.
- 当前专利权人地址: US MD Gaithersburg
- 国际申请: PCT/US20/67003 WO 20201224
- 主分类号: G16H70/60
- IPC分类号: G16H70/60 ; G16H40/20 ; G16H20/10
摘要:
A method of selecting a phage formulation is described wherein the method comprises storing bacterial infection/contamination data at one or more treatment locations in a spatio-temporal infection database, the database comprising at least one of the following data fields: (1) a clinical indication, (2) a bacteria identification, (3) a clinical outcome, (4) a phage resistance status, (5) a phage susceptibility profile, (6) an antibiotic susceptibility profile, and/or (7) a lab test result relating to any one of (1)-(6); identifying one or more phage suitable for inclusion in the phage formulation by analyzing the data fields of (1)-(7) in the database to identify to one or more infections associated with a treatment location during a historical time period based at least on one or more of a frequency of infections/contamination, a geographic clustering of infections/contamination, and/or phage usage data; and generating a selected list of phage to be included in the phage formulation. Uses of formulations are also described.
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