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公开(公告)号：US20190015402A1
公开(公告)日：2019-01-17
申请号：US16042447
申请日：2018-07-23
申请人： AbbVie Inc.
发明人： Mary E. Bellizzi , David A. Betebenner , Jean-Christophe C. Califano , William A. Carroll , Daniel D. Caspi , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Yi Gao , Charles W. Hutchins , Douglas K. Hutchinson , Tammie K. Jinkerson , Warren M. Kati , Ryan G. Keddy , Allan C. Krueger , Wenke Li , Dachun Liu , Clarence J. Maring , Mark A. Matulenko , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , John K. Pratt , John T. Randolph , Todd W. Rockway , Kathy Sarris , Michael D. Tufano , Seble H. Wagaw , Rolf Wagner , Kevin R. Woller
IPC分类号： A61K31/454 , A61K31/4418 , C07D401/14 , A61K45/06 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K31/435 , A61K31/4184 , A61K31/422 , A61K31/4355 , A61K31/438 , A61K31/4178 , C07F7/02 , C07D491/113 , C07D453/00 , C07D417/14 , C07D413/14 , C07D405/14 , C07D403/14 , A61K31/4439
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US10039754B2
公开(公告)日：2018-08-07
申请号：US15431069
申请日：2017-02-13
申请人： AbbVie Inc.
发明人： Mary E. Bellizzi , David A. Betebenner , Jean-Christophe C. Califano , William A. Carroll , Daniel D. Caspi , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Yi Gao , Charles W. Hutchins , Douglas K. Hutchinson , Tammie K. Jinkerson , Warren M. Kati , Ryan G. Keddy , Allan C. Krueger , Wenke Li , Dachun Liu , Clarence J. Maring , Mark A. Matulenko , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , John K. Pratt , John T. Randolph , Todd W. Rockway , Kathy Sarris , Michael D. Tufano , Seble H. Wagaw , Rolf Wagner , Kevin R. Woller
IPC分类号： A61K38/00 , A61K31/454 , A61K45/06 , A61K31/4184 , A61K31/4439 , A61K31/422 , A61K31/438 , A61K31/4545 , A61K31/695 , A61K31/496 , A61K31/506 , A61K31/4418 , A61K31/5377 , A61K31/4355 , A61K31/4178
CPC分类号： A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US09637478B2
公开(公告)日：2017-05-02
申请号：US15141556
申请日：2016-04-28
申请人： AbbVie Inc.
发明人： David A. Betebenner , John K. Pratt , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Kenton L. Longenecker , Clarence J. Maring , John T. Randolph , Todd W. Rockway , Michael D. Tufano , Rolf Wagner , Dachun Liu
IPC分类号： C07D409/10 , C07D239/54 , A61K31/513 , C07D213/64 , A61K31/4418 , C07C311/08 , A61K31/18 , C07D233/72 , A61K31/4166 , A61K31/27 , C07D263/24 , A61K31/421 , C07D239/10 , C07D207/27 , A61K31/402 , C07D405/10 , C07D403/10 , A61K45/06 , A61K31/425 , C07D275/02
CPC分类号： C07D409/10 , A61K31/18 , A61K31/27 , A61K31/402 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/4418 , A61K31/503 , A61K31/513 , A61K45/06 , C07C311/08 , C07D207/27 , C07D213/64 , C07D233/32 , C07D233/72 , C07D239/10 , C07D239/54 , C07D263/22 , C07D263/24 , C07D275/02 , C07D403/10 , C07D405/10 , Y02P20/55
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
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公开(公告)号：US09567355B2
公开(公告)日：2017-02-14
申请号：US15240753
申请日：2016-08-18
申请人： AbbVie Inc. , Abbott Products GmbH
发明人： Clarence J. Maring , John K. Pratt , William A. Carroll , Dachun Liu , David A. Betebenner , Douglas K. Hutchinson , Michael D. Tufano , Todd W. Rockway , Uwe Schoen , Axel Pahl , Andreas Witte
IPC分类号： C07D413/04 , C07D413/14 , A61K31/5395 , A61K31/541 , A61K31/513 , C07D471/04 , C07D405/04 , C07F7/18 , A61K31/4178 , C07D417/14 , A61K31/427 , A61K31/422 , A61K31/437 , A61K31/506 , A61K31/695 , A61K31/5377
CPC分类号： C07F7/1804 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/5395 , A61K31/541 , A61K31/675 , A61K31/695 , A61K45/06 , B65D88/703 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586 , F16K31/363 , Y10T137/86405 , Y10T137/86421
摘要： This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
摘要翻译： 本公开涉及：（a）其特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。
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公开(公告)号：US09353091B2
公开(公告)日：2016-05-31
申请号：US14260504
申请日：2014-04-24
申请人： AbbVie Inc.
发明人： David A. Betebenner , John K. Pratt , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Kenton L. Longenecker , Clarence J. Maring , John T. Randolph , Todd W. Rockway , Michael D. Tufano , Rolf Wagner , Dachun Liu
IPC分类号： A61K31/503 , C07D409/10 , C07C311/08 , C07D207/27 , C07D213/64 , C07D233/32 , C07D233/72 , C07D239/10 , C07D239/54 , C07D263/22 , C07D275/02 , C07D403/10 , C07D405/10 , A61K31/18 , A61K31/27 , A61K31/4166 , A61K31/421 , A61K31/4418 , A61K31/513 , A61K45/06 , C07D263/24
CPC分类号： C07D409/10 , A61K31/18 , A61K31/27 , A61K31/402 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/4418 , A61K31/503 , A61K31/513 , A61K45/06 , C07C311/08 , C07D207/27 , C07D213/64 , C07D233/32 , C07D233/72 , C07D239/10 , C07D239/54 , C07D263/22 , C07D263/24 , C07D275/02 , C07D403/10 , C07D405/10 , Y02P20/55
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
摘要翻译： 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。
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公开(公告)号：US20170157104A1
公开(公告)日：2017-06-08
申请号：US15431069
申请日：2017-02-13
申请人： AbbVie Inc.
发明人： Mary E. Bellizzi , David A. Betebenner , Jean-Christophe C. Califano , William A. Carroll , Daniel D. Caspi , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Yi Gao , Charles W. Hutchins , Douglas K. Hutchinson , Tammie K. Jinkerson , Warren M. Kati , Ryan G. Keddy , Allan C. Krueger , Wenke Li , Dachun Liu , Clarence J. Maring , Mark A. Matulenko , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , John K. Pratt , John T. Randolph , Todd W. Rockway , Kathy Sarris , Michael D. Tufano , Seble H. Wagaw , Rolf Wagner , Kevin R. Woller
IPC分类号： A61K31/454 , A61K31/4184 , A61K31/4439 , A61K31/422 , A61K31/438 , A61K31/4178 , A61K31/695 , A61K31/496 , A61K31/506 , A61K31/4418 , A61K31/5377 , A61K31/4355 , A61K45/06 , A61K31/4545
CPC分类号： A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US09453007B2
公开(公告)日：2016-09-27
申请号：US14852984
申请日：2015-09-14
申请人： AbbVie Inc. , Abbott Products GmbH
发明人： Clarence J. Maring , John K. Pratt , William A. Carroll , Dachun Liu , David A. Betebenner , Douglas K. Hutchinson , Michael D. Tufano , Todd W. Rockway , Uwe Schoen , Axel Pahl , Andreas Witte
IPC分类号： C07D413/14 , C07D413/04 , A61K31/5395 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07F7/18 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07F9/6558
CPC分类号： C07F7/1804 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/5395 , A61K31/541 , A61K31/675 , A61K31/695 , A61K45/06 , B65D88/703 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586 , F16K31/363 , Y10T137/86405 , Y10T137/86421
摘要： This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
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公开(公告)号：US10028937B2
公开(公告)日：2018-07-24
申请号：US15434789
申请日：2017-02-16
申请人： AbbVie Inc.
发明人： Mary E. Bellizzi , David A. Betebenner , Jean-Christophe C. Califano , William A. Carroll , Daniel D. Caspi , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Yi Gao , Charles W. Hutchins , Douglas K. Hutchinson , Tammie K. Jinkerson , Warren M. Kati , Ryan G. Keddy , Allan C. Krueger , Wenke Li , Dachun Liu , Clarence J. Maring , Mark A. Matulenko , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , John K. Pratt , John T. Randolph , Todd W. Rockway , Kathy Sarris , Michael D. Tufano , Seble H. Wagaw , Rolf Wagner , Kevin R. Woller
IPC分类号： A61K38/00 , C07K16/00 , A61K31/4184 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/4418 , A61K31/4545 , A61K31/695 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/438 , A61K31/435
CPC分类号： A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US20160355530A1
公开(公告)日：2016-12-08
申请号：US15240753
申请日：2016-08-18
申请人： AbbVie Inc. , Abbott Products GmbH
发明人： Clarence J. Maring , John K. Pratt , William A. Carroll , Dachun Liu , David A. Betebenner , Douglas K. Hutchinson , Michael D. Tufano , Todd W. Rockway , Uwe Schoen , Axel Pahl , Andreas Witte
IPC分类号： C07F7/18 , A61K31/4178 , C07D417/14 , A61K31/427 , C07D413/14 , A61K31/5377 , C07D413/04 , A61K31/5395 , C07D471/04 , A61K31/437 , A61K31/506 , A61K31/695 , C07D405/04 , A61K31/422
CPC分类号： C07F7/1804 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/5395 , A61K31/541 , A61K31/675 , A61K31/695 , A61K45/06 , B65D88/703 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586 , F16K31/363 , Y10T137/86405 , Y10T137/86421
摘要： This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
摘要翻译： 本公开涉及：（a）其特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。
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公开(公告)号：US20150218194A1
公开(公告)日：2015-08-06
申请号：US14683910
申请日：2015-04-10
申请人： AbbVie Inc.
发明人： Mary E. Bellizzi , David A. Betebenner , Jean C. Califano , Daniel D. Caspi , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Yi Gao , Charles W. Hutchins , Douglas K. Hutchinson , Tammie K. Jinkerson , Warren M. Kati , Ryan G. Keddy , Allan C. Krueger , Wenke Li , Dachun Liu , Clarence J. Maring , Mark A. Matulenko , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , John K. Pratt , John T. Randolph , Todd W. Rockway , Kathy Sarris , Michael D. Tufano , Seble H. Wagaw , Rolf Wagner , Kevin R. Woller
IPC分类号： C07F9/6558 , C07D405/14 , C07D403/14 , C07D401/14 , C07D207/09 , C07D491/113 , C07D413/14 , C07D471/04 , C07C201/06 , C07D207/08 , C07D207/16 , C07D417/14
CPC分类号： C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译： 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。
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