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公开(公告)号：US20230100844A1
公开(公告)日：2023-03-30
申请号：US17941648
申请日：2022-09-09
发明人： Srinivas G. RAO , Glenn SHORT , Carrie BOWEN , Robert BUSBY
IPC分类号： A61K31/55 , A61K31/137 , A61K31/138 , A61K31/4709 , A61K31/357 , A61K31/4525 , A61K31/4164 , A61K31/454 , A61K31/166 , A61K31/343 , A61P25/30 , A61K31/58 , A61K31/635 , A61K31/4706 , A61K31/5415 , A61K31/5513 , A61K31/704 , A61K31/426 , A61K31/5377 , A61K31/502 , A61K31/506
摘要： The present disclosure is directed to methods of improving the therapeutic effectiveness and safety profile of ibogaine for the treatment of conditions including, but not limited to, alcoholism, substance abuse disorder, and opioid use disorder.
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公开(公告)号：US20220388956A1
公开(公告)日：2022-12-08
申请号：US17824861
申请日：2022-05-25
发明人： Glenn SHORT , Majed FAWAZ
IPC分类号： C07D209/16
摘要： This disclosure provides N,N-dimethyltryptamine salts and crystalline salt forms, their preparation, pharmaceutical compositions comprising said salts and crystalline salt forms, and their use in treating neurological diseases and conditions.
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公开(公告)号：US20240116896A1
公开(公告)日：2024-04-11
申请号：US18462120
申请日：2023-09-06
发明人： Tanweer A. KHAN , Alan C. GIBBS , Glenn SHORT , Robert B. PERNI
IPC分类号： C07D403/06 , A61P25/00 , C07D209/14 , C07D471/04 , C07F9/572
CPC分类号： C07D403/06 , A61P25/00 , C07D209/14 , C07D471/04 , C07F9/5728
摘要： The present disclosure provides N,N-dimethyltryptamine (N,N-DMT) derivatives of the present disclosure provides compounds of formula (I), (I-A), (I-B), (I-C), (II), (II-A), (III), and (IV), or pharmaceutically acceptable salts or deuterated forms thereof. Also provided herein are methods of using the N,N-DMT derivatives, e.g., in the treatment of mental health diseases and/or disorders.
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公开(公告)号：US20230202965A1
公开(公告)日：2023-06-29
申请号：US18146785
申请日：2022-12-27
发明人： Glenn SHORT , Robert B. PERNI , Tanweer A. KHAN
IPC分类号： C07C211/42 , C07D217/08
CPC分类号： C07C211/42 , C07D217/08
摘要： Provided herein are compounds of Formula (I), (I-A), (I-B), (II), (II-A), (II-B), (III), (III-A), (IV), and (IV-A), or pharmaceutically acceptable salt thereof described herein. Also provided herein are pharmaceutical compositions comprising a compound Formula (I), (I-A), (I-B), (II), (II-A), (II-B), (III), (III-A), (IV), and (IV-A), or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I), (I-A), (I-B), (II), (II-A), (II-B), (III), (III-A), (IV), and (IV-A), or pharmaceutically acceptable salt thereof, e.g., in the treatment of a mental health disease or disorder.
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公开(公告)号：US20220339139A1
公开(公告)日：2022-10-27
申请号：US17730013
申请日：2022-04-26
发明人： Srinivas G. RAO , Glenn SHORT
IPC分类号： A61K31/4045 , A61K9/00
摘要： A composition including N,N-dimethyltryptamine (DMT) or a pharmaceutically acceptable salt thereof capable of exhibiting a therapeutically effective blood level of DMT from between about 20 and about 60 minutes when administered to a human. A method of treating a neurological disease or condition comprising administering buccally, sublingually, subcutaneously or intranasally to a subject in need thereof an effective amount of DMT or a pharmaceutically acceptable salt thereof, capable of exhibiting a therapeutically effective level of DMT from for between about 20 to about 60 minutes when administered to a human.
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公开(公告)号：US20230357146A1
公开(公告)日：2023-11-09
申请号：US18299347
申请日：2023-04-12
发明人： Robert B. PERNI , Glenn SHORT , Srinivas G. RAO , Tanweer A. KHAN
IPC分类号： C07D209/16 , C07D209/08 , C07D209/12 , C07D209/14 , C07D401/06 , C07D403/06 , C07F9/572
CPC分类号： C07D209/16 , C07D209/08 , C07D209/12 , C07D209/14 , C07D401/06 , C07D403/06 , C07F9/5728
摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R8, R9, X, Y, Z, W, and m are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.
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公开(公告)号：US20230227421A1
公开(公告)日：2023-07-20
申请号：US18147189
申请日：2022-12-28
发明人： Robert B. PERNI , Glenn SHORT , Tanweer A. KHAN
IPC分类号： C07D317/58 , C07D307/79 , C07D319/18
CPC分类号： C07D317/58 , C07D307/79 , C07D319/18
摘要： Provided herein are compounds of Formula (I), Formula (II), and Formula (III) or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7 and A are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), Formula (II), or Formula (III) and methods of using a compound of Formula (I), Formula (II), or Formula (III) , e.g., in the treatment of a mental health disease or disorder.
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8.发明申请公开(公告)号：US20230097530A1
公开(公告)日：2023-03-30
申请号：US17958251
申请日：2022-09-30
发明人： Glenn SHORT , Carrie BOWEN , Rebecca ARON
摘要： The present disclosure provides compositions comprising (R)-MDMA or a pharmaceutically acceptable salt thereof with no or substantially no (S)-MDMA, pharmaceutically acceptable salt thereof, or metabolite thereof. Also provided herein are methods of using the compositions for treating diseases/disorders, e.g., PTSD.
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公开(公告)号：US20230310374A1
公开(公告)日：2023-10-05
申请号：US18192603
申请日：2023-03-29
发明人： Srinivas G. RAO , Glenn SHORT , Carrie BOWEN
IPC分类号： A61K31/4045 , A61P25/06
CPC分类号： A61K31/4045 , A61P25/06
摘要： The present disclosure provides new methods of treating headache or facial pain with 5-methoxytryptamine or 5-hydroxytryptamine and compositions thereof.
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公开(公告)号：US20230227420A1
公开(公告)日：2023-07-20
申请号：US17959256
申请日：2022-10-03
发明人： Srinivas RAO , Glenn SHORT , Robert B. PERNI , Tanweer A. KHAN , Alan C. GIBBS
IPC分类号： C07D317/58 , C07D411/12 , C07F9/30
CPC分类号： C07D317/58 , C07D411/12 , C07F9/30
摘要： The present disclosure provides prodrug compounds of MDMA, MDA, and derivatives thereof having an improved pharmacokinetic profile suitable for the treatment of various neurological diseases.
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