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公开(公告)号：US10357494B2
公开(公告)日：2019-07-23
申请号：US15757133
申请日：2016-09-05
发明人： Bertil Lindmark , Lisa Ooi
IPC分类号： C07D239/94 , A61K31/517 , A61P35/00 , A61K31/51 , A61K9/00 , A61K31/7068 , A61K33/24 , A61K31/282 , A61K31/513
摘要： In one aspect the present disclosure provides a method of sensitizing a cancer patient to chemotherapy by administering a combination therapy comprising; a) a therapeutically effective amount of a compound of formula (I) an enantiomer thereof or a pharmaceutically acceptable salts of any one of the same, and b) a chemotherapeutic agent or a combination of chemotherapeutic agents.
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公开(公告)号：US10682353B2
公开(公告)日：2020-06-16
申请号：US15757189
申请日：2016-09-05
发明人： Bertil Lindmark , Lisa Ooi
IPC分类号： A61K31/517 , C07D239/94 , A61K31/51 , A61P35/00 , A61K9/00 , A61K31/7068 , A61K33/24 , A61K31/282 , A61K31/513
摘要： The present disclosure provides a method of treating a patient with refractory or resistant cancer by administering a therapeutically effective amount of a compound of formula (I), such as Varlitinib, or an enantiomer thereof or a pharmaceutically acceptable salt of any one of the same. Also provided is a compound of formula (I) for use in the treatment of resistant or refractory cancer and use of a compound of formula (I) for the manufacture of a medicament for the treatment of resistant or refractory cancer.
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公开(公告)号：US20190151326A1
公开(公告)日：2019-05-23
申请号：US16252452
申请日：2019-01-18
发明人： Bertil Lindmark , Ann Gee Lisa Ooi
IPC分类号： A61K31/5377 , A61P35/02 , A61K31/517 , A61K31/4545 , A61K31/075 , A61K31/502 , A61K31/201 , A61K31/4745
摘要： A method of treating haematological cancer with a therapy comprising a DHODH inhibitor. Also provided is a combination therapy comprising a pan-HER inhibitor and a DHODH inhibitor for treating a haematological cancer.
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公开(公告)号：US10849899B2
公开(公告)日：2020-12-01
申请号：US16508444
申请日：2019-07-11
发明人： Bertil Lindmark , Lisa Ooi
IPC分类号： C07D239/94 , A61K31/517 , A61P35/00 , A61K31/51 , A61K9/00 , A61K31/7068 , A61K33/24 , A61K31/282 , A61K31/513
摘要： In one aspect the present disclosure provides a method of sensitizing a cancer patient to chemotherapy by administering a combination therapy comprising; a) a therapeutically effective amount of a compound of formula (I) an enantiomer thereof or a pharmaceutically acceptable salts of any one of the same, and b) a chemotherapeutic agent or a combination of chemotherapeutic agents.
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公开(公告)号：US20190117655A1
公开(公告)日：2019-04-25
申请号：US16134736
申请日：2018-09-18
发明人： Bertil Lindmark , Mark Thomas McHale , Lisa Ooi
IPC分类号： A61K31/517 , A61P35/00 , A61K9/00 , C07K16/32 , A61K39/395 , A61K47/68 , A61K31/537 , A61K33/243 , A61K31/7068 , A61K31/513 , A61K31/519
摘要： The present disclosure provides a method of treating a biliary duct cancer, such as cholangiocarcinoma, by administering a therapeutically effective amount of a compound of formula (I), in particular Varlitinib, an enantiomer thereof or a pharmaceutically acceptable salt of any one of the same.
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公开(公告)号：US20200165347A1
公开(公告)日：2020-05-28
申请号：US16625902
申请日：2018-06-29
发明人： Bertil Lindmark , Ann Gee Lisa Ooi
摘要： The present disclosure provides a method of treating cutaneous T cell lymphoma (CTCL), in particular mycosis fungoides and/or Sézary syndrome, comprising administering a therapeutically effective amount of an antagonist antibody or binding fragment thereof specific to the IL-13 receptor to a patient in need thereof.
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公开(公告)号：US20200009144A1
公开(公告)日：2020-01-09
申请号：US16508444
申请日：2019-07-11
发明人： Bertil Lindmark , Lisa Ooi
IPC分类号： A61K31/517 , C07D239/94 , A61K31/51 , A61P35/00 , A61K9/00 , A61K31/7068 , A61K33/24
摘要： In one aspect the present disclosure provides a method of sensitizing a cancer patient to chemotherapy by administering a combination therapy comprising; a) a therapeutically effective amount of a compound of formula (I) an enantiomer thereof or a pharmaceutically acceptable salts of any one of the same, and b) a chemotherapeutic agent or a combination of chemotherapeutic agents
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公开(公告)号：US20190134034A1
公开(公告)日：2019-05-09
申请号：US16094199
申请日：2017-04-21
发明人： Lisa Ooi , Bertil Lindmark
IPC分类号： A61K31/513 , A61P35/00 , A61K31/455 , A61K31/4745 , A61K31/517 , A61K31/519 , A61K31/555 , A61K31/704 , A61K31/7068 , A61K33/24
摘要： A method of treating liver cancer, such as hepatocellular carcinoma, by administering a compound of formula (I), such as Varlitinib, or an enantiomer thereof, or a pharmaceutically acceptable salt thereof. Also provided is a compound of formula (I) for use in the treatment of liver cancer and use of a compound of formula (I) in the manufacture of a medicament for the treatment of liver cancer.
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公开(公告)号：US20180353510A1
公开(公告)日：2018-12-13
申请号：US15757166
申请日：2016-09-05
发明人： Bertil Lindmark , Mark Thomas McHale , Lisa Ooi
IPC分类号： A61K31/517 , A61K9/00 , A61P35/00
CPC分类号： A61K31/517 , A61K9/0053 , A61K31/282 , A61K31/51 , A61K31/513 , A61K31/7068 , A61K33/24 , A61K2300/00 , A61P35/00
摘要： The present disclosure provides a method of treating a biliary duct cancer, such as cholangiocarcinoma, by administering a therapeutically effective amount of a compound of formula (I), in particular Varlitinib, an enantiomer thereof or a pharmaceutically acceptable salt of any one of the same.
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公开(公告)号：US11382903B2
公开(公告)日：2022-07-12
申请号：US16154422
申请日：2018-10-08
IPC分类号： A61K31/4418 , A61P35/02 , A61K31/505 , A61K45/06 , A61K31/075 , A61K31/4545 , A61K31/502 , A61K31/517 , A61K31/553
摘要： A method of treating haematological cancer with a therapy comprising a DHODH inhibitor. Also provided is a combination therapy comprising a pan-HER inhibitor and a DHODH inhibitor for treating a haematological cancer.
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