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公开(公告)号：US20240226286A1
公开(公告)日：2024-07-11
申请号：US18391436
申请日：2023-12-20
申请人： CSL Limited
CPC分类号： A61K39/39 , A61K39/0011 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/55572 , A61K2039/55577
摘要： The present invention provides a composition for raising an immune response against a tumor. The composition comprises at least one tumor antigen, a saponin-based adjuvant, a TLR ligand and a Flt3 ligand.
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公开(公告)号：US20230279129A1
公开(公告)日：2023-09-07
申请号：US18152439
申请日：2023-01-10
申请人： CSL Limited
CPC分类号： C07K16/2866 , A61P13/12 , A61P9/10 , A61K2039/545 , C07K2317/76 , C07K2317/21 , C07K2317/34 , A61K2039/505
摘要： The present disclosure relates to a method for preventing or treating ischemia-reperfusion injury in a subject the method comprising administering a compound that inhibits granulocyte colony stimulating factor (G-CSF) signaling. In some examples, the ischemia-reperfusion injury is due to or associated with tissue or organ transplantation. In some examples, the compound is an antibody.
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公开(公告)号：US11723953B2
公开(公告)日：2023-08-15
申请号：US17368464
申请日：2021-07-06
申请人： CSL Limited
发明人： Samuel Wright , Martin Imboden , Reinhard Bolli , Marcel Waelchli
IPC分类号： A61K38/17 , A61K9/00 , A61K9/127 , A61K31/56 , A61K31/685 , A61K45/06 , A61K31/575
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K31/56 , A61K31/575 , A61K31/685 , A61K45/06 , A61K31/685 , A61K2300/00 , A61K31/56 , A61K2300/00 , A61K38/1709 , A61K2300/00
摘要： A reconstituted high density lipoprotein formulation having relatively low toxicity comprises an apolipoprotein such as ApoAI or fragment thereof, a lipid and a detergent at a level which is about 5-50% of that which would normally cause liver toxicity upon administration to a human. The lipid is optimally phosphatidylcholine at about 30-50 g/L and the molar ratio of apolipoprotein:lipid is optimally in the range 1:40 to 1:75. The formulation is useful for treating diseases or conditions such as cardiovascular disease, hypercholesterolaemia and hypocholesterolaemia inclusive of acute coronary syndrome (ACS), atherosclerosis and myocardial infarction.
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公开(公告)号：US20230159621A1
公开(公告)日：2023-05-25
申请号：US18046371
申请日：2022-10-13
申请人： CSL Limited
IPC分类号： C07K14/76 , C07K14/765
CPC分类号： C07K14/76 , C07K14/765
摘要： The present invention provides a method of polishing albumin to remove contaminants comprising passing an albumin enriched solution through a hydrophobic charge-induction chromatographic resin and recovering the albumin solution which passes through the resin. Also provided is a polished albumin solution prepared by said method.
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公开(公告)号：US20230086472A1
公开(公告)日：2023-03-23
申请号：US17823128
申请日：2022-08-30
申请人： CSL Limited
发明人： Sabine RAUTH , Andrew HAMMET , Kirsten Edwards , Con PANOUSIS
IPC分类号： C07K14/765 , A61K47/64
摘要： A serum albumin variant, or functional fragment thereof, comprising, one or more amino acid substitutions selected from (i) glycine, isoleucine, lysine, methionine, phenylalanine, tryptophan, tyrosine, valine and leucine substituted for glutamine at position (522); (ii) valine substituted for alanine at position (552); and (iii) alanine, glutamic acid, histidine, serine, lysine and arginine substituted for glycine at position (572).
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公开(公告)号：US20210269517A1
公开(公告)日：2021-09-02
申请号：US17276611
申请日：2019-09-18
IPC分类号： C07K16/22 , C12N15/113 , A61P3/00
摘要： The present disclosure provides a method of treating a wasting disorder in a subject, the method comprising administering to the subject a compound that inhibits VEGF-B signalling. The present disclosure also provides a method of treating cancer cachexia in a subject suffering from cancer cachexia, the method comprising 5 administering to the subject a compound that inhibits VEGF-B signaling.
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公开(公告)号：US10961304B2
公开(公告)日：2021-03-30
申请号：US16411321
申请日：2019-05-14
申请人： CSL Limited , B-Creative Sweden AB
发明人： Ulf Eriksson , Ingrid Nilsson , Daniel Lawrence , Enming Joe Su
IPC分类号： A61K31/7105 , A61K38/49 , A61P9/10 , A61K39/395 , C12N15/113 , A61K39/00 , C07K16/22 , A61K45/06 , A61K38/48 , A61P7/04 , A61P25/00
摘要： A method of reducing an effect of stroke in a subject, the method comprising administering to the subject a compound that inhibits VEGF-B signaling.
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公开(公告)号：US10894834B2
公开(公告)日：2021-01-19
申请号：US15779252
申请日：2016-11-25
申请人： CSL Limited
发明人： Catherine Owczarek , Kosta Panousis , Nicholas Wilson , Matthew Hardy , Kirsten Edwards , Veronika Rayzman
摘要： The present disclosure provides a CD131-binding protein comprising an antigen binding domain of an antibody, wherein the antigen binding domain binds to or specifically binds to CD131 and neutralizes signaling by interleukin (IL) 3, IL-5 and granulocyte-macrophage colony stimulating factor (GM-CSF), and uses thereof.
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公开(公告)号：US10829539B2
公开(公告)日：2020-11-10
申请号：US15316870
申请日：2015-04-14
申请人： CSL LIMITED
发明人： Stefan Debus , Holger Lind
IPC分类号： C07K14/755 , C07K1/34 , C12P21/02
摘要： The present invention relates to improved methods for the recombinant production of von Willebrand factor (vWF) in a bioreactor by separating different multimeric forms of vWF with different molecular weight during fermentation.
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公开(公告)号：US20200239546A1
公开(公告)日：2020-07-30
申请号：US16592732
申请日：2019-10-03
申请人： CSL Limited
IPC分类号： C07K14/76 , C07K14/765
摘要： The present invention provides a method of polishing albumin to remove contaminants comprising passing an albumin enriched solution through a hydrophobic charge-induction chromatographic resin and recovering the albumin solution which passes through the resin. Also provided is a polished albumin solution prepared by said method.
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