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公开(公告)号：US20240019429A1
公开(公告)日：2024-01-18
申请号：US18349650
申请日：2023-07-10
Inventor： Shaopeng WANG , Guangzhong MA , Xiaoyan ZHOU
IPC: G01N33/557 , G01N33/543 , G01N21/552
CPC classification number: G01N33/557 , G01N33/54373 , G01N21/553
Abstract: Provided herein are methods of determining binding kinetics of a ligand. In some embodiments, the methods include contacting the ligand with a first surface of a substrate, which first surface comprises an electrically conductive coating and a population of receptors connected to the first surface via one or more linker moieties, wherein the receptors bind, or are capable of binding, to the ligand, applying an alternating current electric field to the substrate to induce the receptors to oscillate proximal to the first surface of the substrate, and detecting changes in oscillation amplitudes of the receptors over a duration. Related receptor oscillator array devices, systems and computer readable media are also provided.
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公开(公告)号：US20250164474A1
公开(公告)日：2025-05-22
申请号：US18956466
申请日：2024-11-22
Inventor： Shaopeng WANG , Xiaoyan ZHOU , Shuang Zhou
IPC: G01N33/543 , B01L3/00 , G01N21/17 , G01N33/68
Abstract: Provided herein are methods of detecting target molecules. The methods include contacting a sample comprising the target molecule with a substrate that comprises a plurality of capture antibodies, or antigen binding portions thereof, that specifically bind to the target molecule to form captured target molecules, and contacting the captured target molecules with a plurality of detection antibodies, or antigen binding portions thereof, that bind to the captured target molecules to form target molecule complexes. The methods also include taking images of the target molecule complexes to produce imaged target molecule complexes, and quantifying an amount of target molecules in the sample using the imaged target molecule complexes. Additional methods as well as related devices and systems are also provided.
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