公开(公告)号：US20220033392A1

公开(公告)日：2022-02-03

申请号：US17226531

申请日：2021-04-09

Applicant: Ariad Pharmaceuticals, Inc.

Inventor： Nicholas E. Bencivenga ,  David C. Dalgarno ,  Joseph M. Gozgit ,  Wei-Sheng Huang ,  Anna Kohlmann ,  Feng Li ,  Jiwei Qi ,  William C. Shakespeare ,  Ranny M. Thomas ,  Yihan Wang ,  Xiaotian Zhu

IPC: C07D417/12 ,  C07D417/04 ,  C07D277/46

Abstract: The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other serine-threonine kinase mediated diseases, having the Formula: wherein A, L, R1, R2, R3, and n are described herein.

公开(公告)号：US20200231588A1

公开(公告)日：2020-07-23

申请号：US16722881

申请日：2019-12-20

Applicant: ARIAD Pharmaceuticals, Inc.

Inventor： Dong Zou ,  Wei-Sheng Huang ,  R. Mathew Thomas ,  Jan Antoinette C. Romero ,  Jiwei Qi ,  Yihan Wang ,  Xiaotian Zhu ,  William C. Shakespeare ,  Rajeswari Sundaramoorthi ,  Chester A. Metcalf, III ,  David C. Dalgarno ,  Tomi K. Sawyer

IPC: C07D471/04 ,  C07D473/34 ,  C07D487/04

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

公开(公告)号：US20130231337A1

公开(公告)日：2013-09-05

申请号：US13801116

申请日：2013-03-13

Applicant: ARIAD PHARMACEUTICALS, INC.

Inventor： Dong Zou ,  Wei-Sheng Huang ,  R. Mathew Thomas ,  Jan Antoinette C. Romero ,  Jiwei Qi ,  Yihan Wang ,  Xiaotian Zhu ,  William C. Shakespeare ,  Rajeswari Sundaramoorthi ,  Chester A. Metcalf, III ,  David C. Dalgarno ,  Tomi K. Sawyer

IPC: C07D487/04 ,  C07D473/34 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D473/34 ,  C07D487/04

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。

公开(公告)号：US11117883B2

公开(公告)日：2021-09-14

申请号：US16469535

申请日：2017-12-14

Applicant: Ariad Pharmaceuticals, Inc.

Inventor： Nicholas E. Bencivenga ,  David C. Dalgarno ,  Joseph M. Gozgit ,  Wei-Sheng Huang ,  Anna Kohlmann ,  Feng Li ,  Jiwei Qi ,  William C. Shakespeare ,  Ranny M. Thomas ,  Yihan Wang ,  Yun Zhang ,  Xiaotian Zhu

IPC: A61K31/4184 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/4427 ,  C07D403/14 ,  C07D403/12 ,  C07D403/04 ,  C07D401/14 ,  C07D401/12 ,  C07D413/14 ,  C07D405/14

Abstract: The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other serine-threonine kinase mediated diseases, having the Formula: (I) where A, L, R1, R2, R3, and n are described herein.

公开(公告)号：US11001580B2

公开(公告)日：2021-05-11

申请号：US16469517

申请日：2017-12-14

Applicant: Ariad Pharmaceuticals, Inc.

Inventor： Nicholas E. Bencivenga ,  David C. Dalgarno ,  Joseph M. Gozgit ,  Wei-Sheng Huang ,  Anna Kohlmann ,  Feng Li ,  Jiwei Qi ,  William C. Shakespeare ,  Ranny M. Thomas ,  Yihan Wang ,  Xiaotian Zhu

IPC: C07D417/14 ,  C07D417/12

Abstract: The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other-threonine kinase mediated diseases, having the Formula: (I) wherein A, L, R1, R2, R3, and n are described herein.

公开(公告)号：US20190031656A1

公开(公告)日：2019-01-31

申请号：US16055362

申请日：2018-08-06

Applicant: ARIAD Pharmaceuticals, Inc.

Inventor： Dong Zou ,  Wei-Sheng Huang ,  R. Mathew Thomas ,  Jan Antoinette C. Romero ,  Jiwei Qi ,  Yihan Wang ,  Xiaotian Zhu ,  William C. Shakespeare ,  Rajeswari Sundaramoorthi ,  Chester A. Metcalf, III ,  David C. Dalgarno ,  Tomi K. Sawyer

IPC: C07D471/04 ,  C07D473/34 ,  C07D487/04

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

公开(公告)号：US09573934B2

公开(公告)日：2017-02-21

申请号：US14607831

申请日：2015-01-28

Applicant: ARIAD Pharmaceuticals, Inc.

Inventor： Feng Li ,  Yihan Wang

IPC: C07D211/60 ,  C07C51/06 ,  C07C209/08 ,  C07C231/02 ,  C07C235/34 ,  C07D205/04 ,  C07D319/06 ,  C07D401/12 ,  C07D319/04 ,  C07B53/00 ,  C07C209/62 ,  C07C209/74 ,  C07C231/18

CPC classification number: C07D401/12 ,  C07B53/00 ,  C07B2200/07 ,  C07C51/06 ,  C07C209/08 ,  C07C209/62 ,  C07C209/74 ,  C07C231/02 ,  C07C231/18 ,  C07C235/34 ,  C07D205/04 ,  C07D211/60 ,  C07D319/04 ,  C07D319/06 ,  C07C211/15 ,  C07C211/13 ,  C07C235/20 ,  C07C59/64

Abstract: The invention features methods and compositions for the synthesis of multimerizing agents.

Abstract translation: 本发明的特征在于用于合成多聚化剂的方法和组合物。

公开(公告)号：US20150148543A1

公开(公告)日：2015-05-28

申请号：US14607831

申请日：2015-01-28

Applicant: ARIAD Pharmaceuticals, Inc.

Inventor： Feng Li ,  Yihan Wang

IPC: C07D401/12 ,  C07D205/04 ,  C07C231/02 ,  C07C51/06 ,  C07C209/08 ,  C07D319/06 ,  C07C235/34

CPC classification number: C07D401/12 ,  C07B53/00 ,  C07B2200/07 ,  C07C51/06 ,  C07C209/08 ,  C07C209/62 ,  C07C209/74 ,  C07C231/02 ,  C07C231/18 ,  C07C235/34 ,  C07D205/04 ,  C07D211/60 ,  C07D319/04 ,  C07D319/06 ,  C07C211/15 ,  C07C211/13 ,  C07C235/20 ,  C07C59/64

Abstract: The invention features methods and compositions for the synthesis of multimerizing agents.

Abstract translation: 本发明的特征在于用于合成多聚化剂的方法和组合物。

公开(公告)号：US20240208960A1

公开(公告)日：2024-06-27

申请号：US18361430

申请日：2023-07-28

Applicant: Ariad Pharmaceuticals, Inc.

Inventor： Nicholas E. Bencivenga ,  David C. Dalgarno ,  Joseph M. Gozgit ,  Wei-Sheng Huang ,  Anna Kohlmann ,  Feng Li ,  Jiwei Qi ,  William C. Shakespeare ,  Ranny M. Thomas ,  Yihan Wang ,  Xiaotian Zhu

IPC: C07D417/14 ,  C07D277/46 ,  C07D417/04 ,  C07D417/12

CPC classification number: C07D417/14 ,  C07D277/46 ,  C07D417/04 ,  C07D417/12

Abstract: The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other serine-threonine kinase mediated diseases, having the Formula:




wherein A, L, R1, R2, R3, and n are described herein.

公开(公告)号：US20220081440A1

公开(公告)日：2022-03-17

申请号：US17498796

申请日：2021-10-12

Applicant: ARIAD Pharmaceuticals, Inc.

Inventor： Dong Zou ,  Wei-Sheng Huang ,  R. Mathew Thomas ,  Jan Antoinette C. Romero ,  Jiwei Qi ,  Yihan Wang ,  Xiaotian Zhu ,  William C. Shakespeare ,  Rajeswari Sundaramoorthi ,  Chester A. Metcalf, III ,  David C. Dalgarno ,  Tomi K. Sawyer

IPC: C07D471/04 ,  C07D487/04 ,  C07D473/34

Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.