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公开(公告)号：US20210147532A1
公开(公告)日：2021-05-20
申请号：US17057223
申请日：2019-05-23
Applicant: ARES TRADING S.A.
Inventor： MARTIN JORDAN , HERVÉ BROLY , MATTHIEU STETTLER , ELODIE CHARBAUT TALAND
Abstract: The present invention relates to a method for controlling the afucosylation level of a glycoprotein composition. The method comprises the control of the afucosylation level by selecting the appropriate temperature and/or pH. The invention also relates to glycoprotein compositions produced according to the method of the invention.
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2.发明申请公开(公告)号：US20200339665A1
公开(公告)日：2020-10-29
申请号：US16954544
申请日：2018-12-19
Applicant: ARES TRADING S.A.
Inventor： DAVID BRUHLMANN , THOMAS VUILLEMIN , MARTIN JORDAN , HERVÉ BROLY
IPC: C07K16/00
Abstract: The present invention relates to methods and compositions for modulating mannosylation profile of recombinant proteins expressed by mammalian host cells during the cell culture process, using a polyether ionophore.
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3.发明申请公开(公告)号：US20190153497A1
公开(公告)日：2019-05-23
申请号：US16300066
申请日：2017-05-10
Applicant: ARES TRADING S.A.
Inventor： MARTIN JORDAN , GABRIELLE LECLERCQ , JONATHAN SOUQUET , HERVE BROLY , DAVID BRUHLMANN
Abstract: The present invention relates to methods and compositions for modulating glycosylation profile, such as the galactosylation profile, of recombinant proteins expressed by mammalian host cells during the cell culture process by supplementing cell culture media with a peracetyl galactose.
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Patent Agency Ranking
公开(公告)号：US20180201897A1
公开(公告)日：2018-07-19
申请号：US15743714
申请日：2016-07-07
Applicant: ARES TRADING S.A.
Inventor： ANAIS MUHR , DAVID BRUHLMANN , MARTIN JORDAN , HERVE BROLY , MATTHIEU STETTLER
Abstract: The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of a triazine dye or supplemented with an effective amount of a triazine dye, whereby production of said protein is increased relative to cells grown without said triazine dye or any other inducer.
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公开(公告)号：US20180201896A1
公开(公告)日：2018-07-19
申请号：US15743709
申请日：2016-07-07
Applicant: ARES TRADING S.A.
Inventor： ANAIS MUHR , DAVID BRUHLMANN , MARTIN JORDAN , HERVE BROLY , MATTHIEU STETTLER
Abstract: The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid (DIDS) or supplemented with an effective amount of DIDS, whereby production of said protein is increased relative to cells grown without DIDS.
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公开(公告)号：US20180320128A1
公开(公告)日：2018-11-08
申请号：US15773186
申请日：2016-11-09
Applicant: ARES TRADING S.A.
Inventor： DAVID BRUHLMANN , MARTIN JORDAN
CPC classification number: C12N1/38 , C07K19/00 , C12N5/0037 , C12N5/0682 , C12N15/85 , C12N2015/8518 , C12N2500/34 , C12N2501/90 , C12N2510/02 , C12N2511/00 , C12P21/005
Abstract: The present invention relates to methods and compositions for modulating glycosylation of recombinant proteins expressed by mammalian host cells during the cell culture process. Also disclosed are methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising a disaccharide or a trisaccharide, while keeping the osmolality constant.
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公开(公告)号：US20180312802A1
公开(公告)日：2018-11-01
申请号：US15772819
申请日：2016-11-01
Applicant: ARES TRADING S.A.
Inventor： JEAN-MARC BIELSER , MARTIN JORDAN
CPC classification number: C12N5/0018 , C12N2510/02 , C12P21/02
Abstract: The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a mammalian host cell expressing a recombinant protein in perfusion mode, using a concentrated cell culture medium.
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8.发明申请公开(公告)号：US20160264940A1
公开(公告)日：2016-09-15
申请号：US15028989
申请日：2014-04-03
Applicant: ARES TRADING S.A.
Inventor： HERVE BROLY , MATTHIEU STETTLER , MARTIN JORDAN , ARNAUD PERILLEUX , YOLANDE ROUILLER
CPC classification number: C12N5/0682 , C12N5/0031 , C12N5/0037 , C12N5/005 , C12N5/16 , C12N2500/12 , C12N2500/14 , C12N2500/16 , C12N2500/22 , C12N2500/24 , C12N2500/32 , C12N2500/35 , C12N2500/38 , C12N2500/40 , C12N2500/46 , C12N2500/60 , C12N2500/90 , C12N2500/95 , C12N2500/99 , C12N2510/02
Abstract: The present invention relates to new serum- and protein-free culture media. These media are high performance culture media, which notably improve mammalian fed-batch cultures. The present invention also relates to methods for preparing and/or designing the medium, and methods of use thereof.
Abstract translation: 本发明涉及新的无血清和蛋白质的培养基。 这些培养基是高性能培养基，其显着地改善哺乳动物补料分批培养。 本发明还涉及用于制备和/或设计该介质的方法及其使用方法。
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