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公开(公告)号：US20130149706A1
公开(公告)日：2013-06-13
申请号：US13761447
申请日：2013-02-07
申请人： APDN (B.V.I.) INC.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , B82Y15/00 , C08K5/09 , C09D7/63 , C09D11/03 , C12Q1/6816 , Y10S977/774 , Y10S977/92 , Y10T436/14 , Y10T436/143333 , C12Q2563/185
摘要： This invention provides compositions that have a light emitting reporter linked to biomolecules, preferably, nucleotide oligomers. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particles of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.
摘要翻译： 本发明提供具有与生物分子连接的发光报道基团的组合物，优选核苷酸寡聚体。 在将生物分子共价连接到光报告颗粒之前，光报告颗粒被甲硅烷基化和官能化以产生包被的光报告颗粒。 本发明的光报告颗粒可以通过诸如UV或IR光的光激发源激发，并且当生物分子是DNA时，通过诸如PCR的扩增技术检测所连接的DNA分子。
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公开(公告)号：US09005985B2
公开(公告)日：2015-04-14
申请号：US13761447
申请日：2013-02-07
申请人： APDN (B.V.I.) Inc.
CPC分类号： C12Q1/6876 , B82Y15/00 , C08K5/09 , C09D7/63 , C09D11/03 , C12Q1/6816 , Y10S977/774 , Y10S977/92 , Y10T436/14 , Y10T436/143333 , C12Q2563/185
摘要： This invention provides compositions that have a light emitting reporter linked to biomolecules, preferably, nucleotide oligomers. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particles of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.
摘要翻译： 本发明提供具有与生物分子连接的发光报道基团的组合物，优选核苷酸寡聚体。 在将生物分子共价连接到光报告颗粒之前，光报告颗粒被甲硅烷基化和官能化以产生包被的光报告颗粒。 本发明的光报告颗粒可以通过诸如UV或IR光的光激发源激发，并且当生物分子是DNA时，通过诸如PCR的扩增技术检测所连接的DNA分子。
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