公开(公告)号：US10543215B2

公开(公告)日：2020-01-28

申请号：US15578305

申请日：2016-06-24

Applicant: AMGEN INC.

Inventor： Robert Andrew Donald Scott ,  Scott Wasserman

IPC: A61K31/55 ,  A61K31/496 ,  A61K45/06 ,  A61P9/04 ,  A61K9/20

Abstract: Disclosed herein are combination therapies for the treatment of heart failure using a cardiac myosin activator, such as omecamtiv mecarbil, and a sinus node If current inhibitor, such as ivabradine. Also disclosed herein are compositions comprising a cardiac myosin activator and a sinus node If current inhibitor.

公开(公告)号：US20180140611A1

公开(公告)日：2018-05-24

申请号：US15578305

申请日：2016-06-24

Applicant: AMGEN INC.

Inventor： Robert Andrew Donald Scott ,  Scott Wasserman

IPC: A61K31/55 ,  A61K31/496 ,  A61P9/04 ,  A61K9/20

CPC classification number: A61K31/55 ,  A61K9/2013 ,  A61K9/2054 ,  A61K31/496 ,  A61K45/06 ,  A61P9/04 ,  A61K2300/00

Abstract: Disclosed herein are combination therapies for the treatment of heart failure using a cardiac myosin activator, such as omecamtiv mecarbil, and a sinus node If current inhibitor, such as ivabradine. Also disclosed herein are compositions comprising a cardiac myosin activator and a sinus node If current inhibitor.

公开(公告)号：US20210047434A1

公开(公告)日：2021-02-18

申请号：US17011433

申请日：2020-09-03

Applicant: Amgen Inc.

Inventor： Joyce Chi Yee Chan ,  John P. Gibbs ,  Clapton S. Dias ,  Scott Wasserman ,  Robert Andrew Donald Scott ,  Christi L. Clogston ,  Timothy David Osslund ,  Evan A. Stein

IPC: C07K16/40 ,  A61K39/395

Abstract: The present invention relates to methods of treating or preventing cholesterol related disorders, such as hypercholesterolemia, hyperlipidemia or dyslipidemia, using antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9). Formulations and methods of producing said formulations are also described.

公开(公告)号：US20150004174A1

公开(公告)日：2015-01-01

申请号：US14316587

申请日：2014-06-26

Applicant: AMGEN INC.

Inventor： Scott Wasserman ,  Robert Andrew Donald Scott ,  Evan A. Stein

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to methods for treating homozygous familial hypercholesterolemia using antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9).

Abstract translation: 本发明涉及使用抗前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型（PCSK9）的抗体治疗纯合家族性高胆固醇血症的方法。