公开(公告)号：US12178873B2

公开(公告)日：2024-12-31

申请号：US17326725

申请日：2021-05-21

Applicant: AMGEN INC.

Inventor： Timothy David Osslund

IPC: A61K39/395 ,  A61K9/00 ,  A61K9/08 ,  A61K39/00 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  C07K16/22

Abstract: Discloses herein are high concentration antibody thrmulations comprising an anti-sclerostin immunoglobulin and an acetate salt and/or an acetate buffer and methods of use.

公开(公告)号：US11040102B2

公开(公告)日：2021-06-22

申请号：US16045928

申请日：2018-07-26

Applicant: Amgen Inc.

Inventor： Timothy David Osslund

IPC: A61K39/395 ,  C07K16/22 ,  A61K9/08 ,  A61K39/00 ,  A61K47/14 ,  A61K9/00 ,  A61K47/12 ,  A61K47/24

Abstract: Discloses herein are high concentration antibody formulations comprising an anti-sclerostin immunoglobulin and an acetate salt and/or an acetate buffer and methods of use.

公开(公告)号：US11773184B2

公开(公告)日：2023-10-03

申请号：US16799601

申请日：2020-02-24

Applicant: AMGEN INC.

Inventor： Twinkle R. Christian ,  Christi L. Clogston ,  Timothy David Osslund

IPC: C07K16/40 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K39/39591 ,  C07K2317/565

Abstract: Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.

公开(公告)号：US20210275671A1

公开(公告)日：2021-09-09

申请号：US17326725

申请日：2021-05-21

Applicant: AMGEN INC.

Inventor： Timothy David Osslund

IPC: A61K47/14 ,  A61K9/00 ,  A61K39/395 ,  A61K47/12 ,  C07K16/22 ,  A61K9/08 ,  A61K47/24

Abstract: Discloses herein are high concentration antibody formulations comprising an anti-sclerostin immunoglobulin and an acetate salt and/or an acetate buffer and methods of use.

公开(公告)号：US20210047434A1

公开(公告)日：2021-02-18

申请号：US17011433

申请日：2020-09-03

Applicant: Amgen Inc.

Inventor： Joyce Chi Yee Chan ,  John P. Gibbs ,  Clapton S. Dias ,  Scott Wasserman ,  Robert Andrew Donald Scott ,  Christi L. Clogston ,  Timothy David Osslund ,  Evan A. Stein

IPC: C07K16/40 ,  A61K39/395

Abstract: The present invention relates to methods of treating or preventing cholesterol related disorders, such as hypercholesterolemia, hyperlipidemia or dyslipidemia, using antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9). Formulations and methods of producing said formulations are also described.

公开(公告)号：US20190022230A1

公开(公告)日：2019-01-24

申请号：US16045928

申请日：2018-07-26

Applicant: Amgen Inc.

Inventor： Timothy David Osslund

IPC: A61K47/14 ,  A61K47/12 ,  A61K9/08 ,  C07K16/22 ,  A61K47/24 ,  A61K9/00 ,  A61K39/395 ,  A61K39/00

Abstract: Discloses herein are high concentration antibody formulations comprising an anti-sclerostin immunoglobulin and an acetate salt and/or an acetate buffer and methods of use.

公开(公告)号：US20140030270A1

公开(公告)日：2014-01-30

申请号：US13886180

申请日：2013-05-02

Applicant: Amgen Inc.

Inventor： Christi L. Clogston ,  Timothy David Osslund

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention relates to methods of treating or preventing cholesterol related disorders, such as hypercholesterolemia, hyperlipidemia or dyslipidemia, using antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9). Formulations and methods of producing said formulations are also described.

Abstract translation: 本发明涉及使用抗前驱蛋白转化酶枯草杆菌蛋白酶/ 9型（KKK）的抗体来治疗或预防胆固醇相关疾病如高胆固醇血症，高脂血症或血脂异常的方法。 还描述了制备所述制剂的制剂和方法。