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公开(公告)号：US20210024626A1
公开(公告)日：2021-01-28
申请号：US17060905
申请日：2020-10-01
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC: C07K16/24 , A61K47/68 , A61K39/395
Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US20200181255A1
公开(公告)日：2020-06-11
申请号：US16793610
申请日：2020-02-18
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC: C07K16/24 , A61K39/395 , A61K47/68
Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US20190071498A1
公开(公告)日：2019-03-07
申请号：US16194896
申请日：2018-11-19
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC: C07K16/24 , A61K39/395 , A61K47/68 , A61K39/00
Abstract: Antigen binding proteins that bind to human IL-23 protein arc provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes arc also provided.
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公开(公告)号：US12012449B2
公开(公告)日：2024-06-18
申请号：US17525421
申请日：2021-11-12
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC: A61K39/395 , A61K47/68 , C07K16/24 , A61K39/00
CPC classification number: C07K16/244 , A61K39/395 , A61K47/6845 , C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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公开(公告)号：US20210230267A1
公开(公告)日：2021-07-29
申请号：US17229607
申请日：2021-04-13
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC: C07K16/24 , A61K47/68 , A61K39/395
Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20180030116A1
公开(公告)日：2018-02-01
申请号：US15547730
申请日：2015-08-26
Applicant: AMGEN INC.
Inventor： Jason C. O'Neill , Randal R. Ketchem , Taeweon Lee , Vishnu Chintalgattu , Jennitte Leann Stevens
IPC: C07K14/81
CPC classification number: C07K14/8146 , A61K38/00
Abstract: The application concerns tissue inhibitor of metalloproteinase 3 (TIMP-3) muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them; in particular, muteins of TIMP-3 with specific amino acid substitutions in order to introduce N-linked glycosylation sites.
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公开(公告)号：US09464139B2
公开(公告)日：2016-10-11
申请号：US14472116
申请日：2014-08-28
Applicant: AMGEN INC.
Inventor： Courtney Beers , Jason C. O'Neill , Ian Foltz , Randal R. Ketchem , Julia C. Piasecki
CPC classification number: C07K16/2878 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/94
Abstract: Antigen binding proteins that activate GITR are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided. The antigen binding proteins have value in therapeutic methods in which it is useful to stimulate GITR signaling, thereby inducing or enhancing an immune response in a subject. Accordingly, the antigen binding proteins have utility in a variety of immunotherapy treatments, including treatment of various cancers and infections.
Abstract translation: 提供激活GITR的抗原结合蛋白。 还提供了编码抗原结合蛋白的核酸和含有此类核酸的载体和细胞。 抗原结合蛋白在治疗方法中具有价值，其中它可用于刺激GITR信号传导，从而诱导或增强受试者的免疫应答。 因此，抗原结合蛋白具有多种免疫治疗方法的用途，包括治疗各种癌症和感染。
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公开(公告)号：US20220056122A1
公开(公告)日：2022-02-24
申请号：US17525421
申请日：2021-11-12
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randel R. Ketchem
IPC: C07K16/24 , A61K47/68 , A61K39/395
Abstract: Antigen binding proteins that bind to human IL-23 protein arc provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes arc also provided.
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9.发明授权公开(公告)号：US11149078B2
公开(公告)日：2021-10-19
申请号：US15547730
申请日：2015-08-26
Applicant: AMGEN INC.
Inventor： Jason C. O'Neill , Randal R. Ketchem , Taeweon Lee , Vishnu Chintalgattu , Jennitte Leann Stevens
Abstract: The application concerns tissue inhibitor of metalloproteinase 3 (TIMP-3) muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them; in particular, muteins of TIMP-3 with specific amino acid substitutions in order to introduce N-linked glycosylation sites.
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公开(公告)号：US20190322737A1
公开(公告)日：2019-10-24
申请号：US16453482
申请日：2019-06-26
Applicant: AMGEN INC.
Inventor： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC: C07K16/24 , A61K39/395 , A61K47/68
Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
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