公开(公告)号：US20180030116A1

公开(公告)日：2018-02-01

申请号：US15547730

申请日：2015-08-26

Applicant: AMGEN INC.

Inventor： Jason C. O'Neill ,  Randal R. Ketchem ,  Taeweon Lee ,  Vishnu Chintalgattu ,  Jennitte Leann Stevens

IPC: C07K14/81

CPC classification number: C07K14/8146 ,  A61K38/00

Abstract: The application concerns tissue inhibitor of metalloproteinase 3 (TIMP-3) muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them; in particular, muteins of TIMP-3 with specific amino acid substitutions in order to introduce N-linked glycosylation sites.

公开(公告)号：US11149078B2

公开(公告)日：2021-10-19

申请号：US15547730

申请日：2015-08-26

Applicant: AMGEN INC.

Inventor： Jason C. O'Neill ,  Randal R. Ketchem ,  Taeweon Lee ,  Vishnu Chintalgattu ,  Jennitte Leann Stevens

IPC: C07K14/81 ,  A61K38/00

Abstract: The application concerns tissue inhibitor of metalloproteinase 3 (TIMP-3) muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them; in particular, muteins of TIMP-3 with specific amino acid substitutions in order to introduce N-linked glycosylation sites.