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    Human Antigen Binding Proteins That Bind Beta-Klotho, FGF Receptors and Complexes Thereof
    1.
    发明申请
    Human Antigen Binding Proteins That Bind Beta-Klotho, FGF Receptors and Complexes Thereof 有权

    公开(公告)号：US20250163160A1

    公开(公告)日：2025-05-22

    申请号：US18824740

    申请日：2024-09-04

    Applicant: AMGEN INC.

    Inventor： Shaw-Fen Sylvia Hu ,  Ian Nevin Foltz ,  Chadwick Terence King ,  Yang Li ,  Taruna Arora

    IPC: C07K16/28 ,  A61K39/00 ,  C07K14/71 ,  C07K16/18 ,  C07K16/40

    Abstract: The present invention provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising Q-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

    ANTIBODIES TARGETING CDH19 FOR MELANOMA
    2.
    发明申请
    ANTIBODIES TARGETING CDH19 FOR MELANOMA 有权

    公开(公告)号：US20250084160A1

    公开(公告)日：2025-03-13

    申请号：US18610640

    申请日：2024-03-20

    Applicant: Amgen Inc.

    Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan

    IPC: C07K16/28 ,  A61K39/00 ,  A61K47/68 ,  C07K16/30

    Abstract: The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.

    ANTIBODIES TARGETING CDH19 FOR MELANOMA
    9.
    发明申请
    ANTIBODIES TARGETING CDH19 FOR MELANOMA 有权

    公开(公告)号：US20220127354A1

    公开(公告)日：2022-04-28

    申请号：US17326717

    申请日：2021-05-21

    Applicant: AMGEN INC.

    Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan

    IPC: C07K16/28 ,  A61K47/68 ,  C07K16/30

    Abstract: The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.

    Antibodies targeting CDH19 for melanoma
    10.
    发明授权
    Antibodies targeting CDH19 for melanoma 有权

    公开(公告)号：US11053311B2

    公开(公告)日：2021-07-06

    申请号：US15878047

    申请日：2018-01-23

    Applicant: AMGEN INC.

    Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan

    IPC: A61K39/00 ,  C07K16/28 ,  A61K47/68 ,  C07K16/30

    Abstract: The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.

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