公开(公告)号：US20150250890A1

公开(公告)日：2015-09-10

申请号：US14429576

申请日：2013-09-11

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Ki Dong Park ,  Jin Woo Bae ,  Kyung Min Park ,  Eugene Lih ,  Bae Young Kim ,  Yunki Lee

IPC: A61K47/34 ,  A61K47/36 ,  C12M1/26 ,  C12M1/12 ,  C12M1/40 ,  A61K47/42 ,  A61K47/38

CPC classification number: A61L27/52 ,  A61L2400/06

Abstract: The present invention relates to a method for preparing a hydrogel, comprising the steps of: preparing an enzyme-immobilized support; making contacting with a polymer having a phenol or aniline functional group at a side change and the support in the presence of hydrogen peroxide to cross-link the same; and obtaining a hydrogel by separating the enzyme-immobilized support.According to the present invention, a hydrogel is formed by cross-linking a polymer having a phenol or aniline functional group at a side chain through an enzyme-immobilized support, and thus a hydrogel containing no enzymes is obtained. Therefore, the biomedical application range of a hydrogel can be expanded since it is possible to overcome an in vivo safety problem such as immune reaction caused by an enzyme.

Abstract translation: 本发明涉及一种制备水凝胶的方法，包括以下步骤：制备酶固定的载体; 使其与具有苯酚或苯胺官能团的聚合物在一侧发生交联，并且在过氧化氢存在下与支持物交联; 并通过分离酶固定的载体获得水凝胶。 根据本发明，通过使酶固定化载体在侧链上交联具有苯酚或苯胺官能团的聚合物形成水凝胶，得到不含酶的水凝胶。 因此，可以扩展水凝胶的生物医学应用范围，因为可以克服体内安全性问题，例如由酶引起的免疫反应。

公开(公告)号：US10888621B2

公开(公告)日：2021-01-12

申请号：US15475948

申请日：2017-03-31

Applicant: AJOU UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION ,  INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Ki Dong Park ,  Kyung Min Park ,  Yun Ki Lee ,  Thi Thai Thanh Hoang ,  Thi Phuong Le

IPC: A61K38/21 ,  A61K47/40 ,  A61K9/00 ,  A61K9/06 ,  A61L26/00

Abstract: Provided are an injectable tissue adhesive hydrogel including gamma-cyclodextrin (γ-CD). When such an injectable tissue adhesive hydrogel including the γ-CD is used as a skin glue, based on a fact that the γ-CD has a bigger hydrophobic cavity than that of α- and β-CDs, the injectable tissue adhesive hydrogel including the γ-CD has stronger interactions than host-guest interactions. In addition, hydrogen bonding in the injectable tissue adhesive hydrogel including the γ-CD can improve both cohesiveness and adhesiveness of gelatin. The injectable tissue adhesive hydrogel including the γ-CD having excellent cell viability is used for adhesion of a skin incision, to thereby effectively promote tissue regeneration.

公开(公告)号：US09844610B2

公开(公告)日：2017-12-19

申请号：US14429576

申请日：2013-09-11

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Ki Dong Park ,  Jin Woo Bae ,  Kyung Min Park ,  Eugene Lih ,  Bae Young Kim ,  Yunki Lee

IPC: C12N9/00 ,  A61L27/52

CPC classification number: A61L27/52 ,  A61L2400/06

Abstract: The present invention relates to a method for preparing a hydrogel, including the steps of: preparing an enzyme-immobilized support; making contacting with a polymer having a phenol or aniline functional group at a side change and the support in the presence of hydrogen peroxide to cross-link the same; and obtaining a hydrogel by separating the enzyme-immobilized support. According to the present invention, a hydrogel is formed by cross-linking a polymer having a phenol or aniline functional group at a side chain through an enzyme-immobilized support, and thus a hydrogel containing no enzymes is obtained. Therefore, the biomedical application range of a hydrogel can be expanded since it is possible to overcome an in vivo safety problem such as immune reaction caused by an enzyme.

公开(公告)号：US20220387597A1

公开(公告)日：2022-12-08

申请号：US17771160

申请日：2020-10-22

Applicant: SEOUL NATIONAL UNIVERSITY HOSPITAL ,  AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  CHUNG ANG University Industry Academic Cooperation Foundation

Inventor： Se Joon Woo ,  Ki Dong Park ,  Si Min Lee ,  Joo Young Son ,  Wonhee Suh

IPC: A61K47/36 ,  A61K9/06 ,  A61K9/00 ,  C08B37/08 ,  C08J3/075 ,  C08J3/24 ,  A61F9/00

Abstract: Provided are an injectable intraocular microgel and an injectable intraocular hydrogel that are safe to a human body and that can release a drug in the eye for a long period of time. This injectable intraocular microgel may have a form in which a drug is loaded on a hyaluronic acid microgel generated by causing hyaluronic acid copolymers to cross-link with each other through a w/o emulsion method.

公开(公告)号：US09446129B2

公开(公告)日：2016-09-20

申请号：US14309911

申请日：2014-06-20

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Ki Dong Park ,  Jong Hoon Choi

IPC: A61K9/70 ,  A61K45/06 ,  A61K31/137 ,  A61K31/337 ,  A61K31/727 ,  A61L33/00 ,  A61L27/52 ,  A61L31/10 ,  A61L31/16 ,  A61K47/48

CPC classification number: A61K45/06 ,  A61K31/137 ,  A61K31/337 ,  A61K31/727 ,  A61K47/48215 ,  A61K47/60 ,  A61L27/52 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0011 ,  A61L2420/08

Abstract: Disclosed is a multi-layered structure for drug reservoir, comprising a first micelle layer for crosslinking and adhesion, comprising a drug, a multi-arm polymer, a phenol derivative, and a dopa derivative and having a one or two-layered structure; a second micelle layer for crosslinking, being stacked on the first micelle layer, comprising a drug, a multi-arm polymer, and a phenol derivative, and having a one or two-layered structure; and a physiologically active material layer, being stacked on the second micelle layer, comprising a physiologically active material, a water-soluble polymer, and a phenol derivative, and having a one or two-layered structure.

Abstract translation: 本发明公开了一种用于药物储存器的多层结构，包括用于交联和粘附的第一胶束层，其包含药物，多臂聚合物，苯酚衍生物和多巴衍生物并具有一层或两层结构; 层叠在第一胶束层上的用于交联的第二胶束层，包含药物，多臂聚合物和苯酚衍生物，并具有一层或两层结构; 和层叠在第二胶束层上的生理活性物质层，其包含生理活性物质，水溶性聚合物和苯酚衍生物，并且具有一层或两层结构。