公开(公告)号：US20220395552A1

公开(公告)日：2022-12-15

申请号：US17635127

申请日：2020-08-12

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Gwang LEE ,  Tae-Hwan SHIN ,  Yup KANG ,  Jong-Young KWAK ,  Dayeon LEE

IPC: A61K38/06 ,  A61K31/191

Abstract: The present invention relates to a composition for inhibiting the toxicity with respect to nanoparticles and particulate matters generated from the environment. Since it has been confirmed that a decrease in intracellular ATP, a decrease in cell viability, inflammation-induced morphological changes in cells and cell activation, which are induced by nanoparticles or environmentally-derived particulate matters, are inhibited by means of the composition of the present invention, the composition may be utilized as a reducing substance for the toxicity of nanoparticles and particulate matters.

公开(公告)号：US20200283725A1

公开(公告)日：2020-09-10

申请号：US16803957

申请日：2020-02-27

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  NANOFAENTECH CO., Ltd.

Inventor： Jong-Young KWAK ,  Minho CHOI ,  Gwang LEE

IPC: C12N5/00 ,  D01D5/00 ,  D01F6/14

Abstract: A method of preparing a polyvinyl alcohol nanofiber membrane includes a material for controlling cell specific adhesion, and a nanofiber membrane that can maintain cellular functions such as cell activity and growth is prepared by adding aqueous solutions containing a polyacrylic acid and a glutaraldehyde crosslinking agent in a polyvinyl alcohol and materials capable of enhancing or regulating cell adhesion, electrospinning, treating with hydrochloric acid vapor and dimethylformaldehyde solvent and treating with sodium hydroxide to control the cell adhesion.

公开(公告)号：US20190194715A1

公开(公告)日：2019-06-27

申请号：US16311161

申请日：2017-05-12

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Tae Hwan SHIN ,  Geetika PHUKAN ,  Man Jeong PAIK ,  Hyeon-Seong LEE ,  Hyung-Jin PARK ,  Da Yeon LEE ,  Gwang LEE

IPC: C12Q1/02 ,  C12Q1/6881 ,  C12Q1/6837

CPC classification number: C12Q1/025 ,  C12Q1/68 ,  C12Q1/6837 ,  C12Q1/6881 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/142 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: A method of assessing neurotoxicity of nanoparticles, includes: preparing a tissue or cell sample of mammal exposed to the nanoparticles; analyzing at least one polyamine metabolite selected from the group consisting of putrescine, N1-acetylspermidine, N8-acetylspermidine, N1-acetylspermine and spermine in the sample; and comparing expression degree of the polyamine metabolite with that of a control.