公开(公告)号：US20190194715A1

公开(公告)日：2019-06-27

申请号：US16311161

申请日：2017-05-12

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Tae Hwan SHIN ,  Geetika PHUKAN ,  Man Jeong PAIK ,  Hyeon-Seong LEE ,  Hyung-Jin PARK ,  Da Yeon LEE ,  Gwang LEE

IPC: C12Q1/02 ,  C12Q1/6881 ,  C12Q1/6837

CPC classification number: C12Q1/025 ,  C12Q1/68 ,  C12Q1/6837 ,  C12Q1/6881 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/142 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: A method of assessing neurotoxicity of nanoparticles, includes: preparing a tissue or cell sample of mammal exposed to the nanoparticles; analyzing at least one polyamine metabolite selected from the group consisting of putrescine, N1-acetylspermidine, N8-acetylspermidine, N1-acetylspermine and spermine in the sample; and comparing expression degree of the polyamine metabolite with that of a control.