公开(公告)号：US20200239851A1

公开(公告)日：2020-07-30

申请号：US16649986

申请日：2018-09-21

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Jong-Young KWAK ,  Min Gyu SONG ,  So Hee KIM ,  Min Ho CHOI

IPC: C12N5/071 ,  C12N5/00 ,  G01N33/50

Abstract: Disclosed is a nanofiber-based long-term primary hepatocyte culture system and a culture method, wherein the primary hepatocyte culture system has an advantage that it can culture cells in three-dimensions in vitro to maintain the original physiological activity of low proliferative primary hepatocytes for a long time by co-culturing indirectly by separating primary hepatocytes and hepatic non-parenchymal cells with a support consisting of nanofibers therebetween without direct co-culture.

公开(公告)号：US20200283725A1

公开(公告)日：2020-09-10

申请号：US16803957

申请日：2020-02-27

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  NANOFAENTECH CO., Ltd.

Inventor： Jong-Young KWAK ,  Minho CHOI ,  Gwang LEE

IPC: C12N5/00 ,  D01D5/00 ,  D01F6/14

Abstract: A method of preparing a polyvinyl alcohol nanofiber membrane includes a material for controlling cell specific adhesion, and a nanofiber membrane that can maintain cellular functions such as cell activity and growth is prepared by adding aqueous solutions containing a polyacrylic acid and a glutaraldehyde crosslinking agent in a polyvinyl alcohol and materials capable of enhancing or regulating cell adhesion, electrospinning, treating with hydrochloric acid vapor and dimethylformaldehyde solvent and treating with sodium hydroxide to control the cell adhesion.

公开(公告)号：US20220395552A1

公开(公告)日：2022-12-15

申请号：US17635127

申请日：2020-08-12

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Gwang LEE ,  Tae-Hwan SHIN ,  Yup KANG ,  Jong-Young KWAK ,  Dayeon LEE

IPC: A61K38/06 ,  A61K31/191

Abstract: The present invention relates to a composition for inhibiting the toxicity with respect to nanoparticles and particulate matters generated from the environment. Since it has been confirmed that a decrease in intracellular ATP, a decrease in cell viability, inflammation-induced morphological changes in cells and cell activation, which are induced by nanoparticles or environmentally-derived particulate matters, are inhibited by means of the composition of the present invention, the composition may be utilized as a reducing substance for the toxicity of nanoparticles and particulate matters.