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公开(公告)号：US09862698B2
公开(公告)日：2018-01-09
申请号：US14571647
申请日：2014-12-16
发明人： Gary A. Piazza , Xi Chen , Adam B. Keeton , Michael R. Boyd
IPC分类号： C07D317/64 , A61K31/44 , A61K31/40 , A61K31/401 , C07D307/54 , A61K31/341 , C07D211/56 , C07D207/14 , C07D207/337 , A61K31/445 , A61K31/36 , C07D213/75 , C07D235/30 , C07D405/12 , C07C233/58 , C07D213/24 , C07D307/38 , C07D307/52 , C07C235/32 , C07C237/20
CPC分类号： C07D317/64 , A61K31/341 , A61K31/36 , A61K31/40 , A61K31/401 , A61K31/44 , A61K31/445 , A61K45/06 , A61K2300/00 , C07C233/58 , C07C235/32 , C07C237/20 , C07C2601/02 , C07C2602/08 , C07D207/14 , C07D207/337 , C07D211/56 , C07D213/24 , C07D213/75 , C07D235/30 , C07D307/38 , C07D307/52 , C07D307/54 , C07D405/12
摘要： Disclosed are compounds, for example, compounds of formula I, wherein R, R0, R1-R8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.
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公开(公告)号：US20170342021A1
公开(公告)日：2017-11-30
申请号：US15537222
申请日：2014-12-16
发明人： Gary A. Piazza , Xi Chen , Adam B. Keeton
IPC分类号： C07C235/38 , C07C271/44 , A61K31/255 , A61K31/167 , C07C309/66 , A61K31/325 , C07C2602/08
CPC分类号： C07C235/38 , A61K31/167 , A61K31/255 , A61K31/325 , A61K45/06 , C07C271/44 , C07C309/66 , C07C2602/08 , A61K2300/00
摘要： Disclosed are compounds, for example, compounds of formula (I), wherein R, R0 R1-R8, n, X, Y, Y1, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.
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公开(公告)号：US20160175275A1
公开(公告)日：2016-06-23
申请号：US15056202
申请日：2016-02-29
发明人： Gary A. Piazza , Xi Chen , Adam B. Keeton , Michael R. Boyd
IPC分类号： A61K31/341 , A61K31/4406 , G01N33/574 , A61K31/165 , A61K31/167 , A61K45/06 , A61K31/40
CPC分类号： C07D317/64 , A61K31/165 , A61K31/167 , A61K31/216 , A61K31/341 , A61K31/36 , A61K31/40 , A61K31/401 , A61K31/421 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/445 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K45/06 , A61K2300/00 , C07C233/58 , C07C235/32 , C07C235/34 , C07C237/20 , C07C311/29 , C07C2601/02 , C07C2602/08 , C07D207/14 , C07D207/335 , C07D207/337 , C07D211/56 , C07D213/24 , C07D213/40 , C07D213/75 , C07D235/30 , C07D307/38 , C07D307/52 , C07D307/54 , C07D405/12 , G01N33/5748 , A61K2800/00
摘要： Disclosed are compounds, for example, a compound of formula I, wherein R, R0, R1-R8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.
摘要翻译： 公开了化合物，例如式I化合物，其中R，R 0，R 1 -R 8，n，X，Y，Y'和E如本文所述，含有这些化合物的药物组合物，以及治疗或预防的方法 由ras基因介导的疾病或病症，例如癌症。
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公开(公告)号：US20160168108A1
公开(公告)日：2016-06-16
申请号：US14571690
申请日：2014-12-16
发明人： Gary A. Piazza , Xi Chen , Adam B. Keeton , Michael R. Boyd
IPC分类号： C07D307/52 , C07D213/75 , C07C311/29 , C07D213/40 , C07D207/335 , C07C235/34 , C07D207/14
摘要： Disclosed are compounds, for example, a compound of formula I, wherein R, R0, R1-R8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.
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5.发明申请公开(公告)号：US20160168113A1
公开(公告)日：2016-06-16
申请号：US14571647
申请日：2014-12-16
发明人： Gary A. Piazza , Xi Chen , Adam B. Keeton , Michael R. Boyd
IPC分类号： C07D317/64 , A61K31/44 , A61K31/40 , A61K31/401 , C07D307/54 , A61K31/341 , C07D211/56 , C07D213/75 , C07D207/14 , C07D207/337 , A61K31/445 , A61K31/36
CPC分类号： C07D317/64 , A61K31/341 , A61K31/36 , A61K31/40 , A61K31/401 , A61K31/44 , A61K31/445 , A61K45/06 , A61K2300/00 , C07C233/58 , C07C235/32 , C07C237/20 , C07C2601/02 , C07C2602/08 , C07D207/14 , C07D207/337 , C07D211/56 , C07D213/24 , C07D213/75 , C07D235/30 , C07D307/38 , C07D307/52 , C07D307/54 , C07D405/12
摘要： Disclosed are compounds, for example, compounds of formula I, wherein R, R0, R1-R8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.
摘要翻译： 公开了化合物，例如式I化合物，其中R，R 0，R 1 -R 8，n，X，Y，Y'和E如本文所述，含有这些化合物的药物组合物，以及治疗或预防 疾病或病症，例如癌症。
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公开(公告)号：US09931315B2
公开(公告)日：2018-04-03
申请号：US15056202
申请日：2016-02-29
发明人： Gary A. Piazza , Xi Chen , Adam B. Keeton , Michael R. Boyd
IPC分类号： A61K31/341 , C07D307/52 , C07C235/34 , C07D213/75 , C07D207/14 , C07D213/40 , C07D207/335 , C07C311/29 , A61K31/165 , A61K31/216 , A61K31/401 , A61K31/421 , A61K31/4402 , A61K31/4406 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/167 , A61K31/40 , A61K45/06 , G01N33/574
CPC分类号： C07D317/64 , A61K31/165 , A61K31/167 , A61K31/216 , A61K31/341 , A61K31/36 , A61K31/40 , A61K31/401 , A61K31/421 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/445 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K45/06 , A61K2300/00 , C07C233/58 , C07C235/32 , C07C235/34 , C07C237/20 , C07C311/29 , C07C2601/02 , C07C2602/08 , C07D207/14 , C07D207/335 , C07D207/337 , C07D211/56 , C07D213/24 , C07D213/40 , C07D213/75 , C07D235/30 , C07D307/38 , C07D307/52 , C07D307/54 , C07D405/12 , G01N33/5748 , A61K2800/00
摘要： Disclosed are compounds, for example, a compound of formula I, wherein R, R0, R1-R8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.
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