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公开(公告)号：US09610011B2
公开(公告)日：2017-04-04
申请号：US15172083
申请日：2016-06-02
Applicant: ABBOTT MEDICAL OPTICS INC.
Inventor： Stanley W. Huth , Denise Tran
CPC classification number: A61B3/0025 , A61B3/1005 , A61B3/101 , A61B3/103 , G01B9/02 , G01B11/06 , G01J3/45
Abstract: A method for determining optical properties of a corneal region. The method includes the steps of obtaining a combined tear film aqueous layer plus lipid layer thickness; obtaining a tear film lipid layer thickness; subtracting the tear film lipid layer thickness from the combined tear film aqueous layer plus lipid layer thickness to obtain a tear film aqueous layer thickness; and determining a corneal layer refractive index based on the tear film lipid layer thickness and the tear film aqueous layer thickness.
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2.发明申请公开(公告)号：US20170280992A1
公开(公告)日：2017-10-05
申请号：US15627077
申请日：2017-06-19
Applicant: ABBOTT MEDICAL OPTICS INC.
Inventor： Stanley W. Huth , Denise Tran
CPC classification number: A61B3/101 , A61B3/0025 , A61B3/1005 , G01B11/06 , G01J3/45
Abstract: A method for determining reflectivity of a tear film lipid layer of a patient and recommending a course of treatment based on the same. The method includes the steps of: measuring a tear film aqueous plus lipid layer relative reflectance spectrum using a wavelength-dependent optical interferometer; converting the measured tear film aqueous plus lipid layer relative reflectance spectrum to a calculated absolute reflectance spectrum; comparing the calculated absolute reflectance spectrum to a theoretical absolute lipid reflectance spectrum to determine a tear film lipid layer thickness; and determining a reflectivity value for the tear film lipid layer thickness at a first wavelength of light corresponding to ultraviolet, violet, or blue light.
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3.发明授权公开(公告)号：US09681802B2
公开(公告)日：2017-06-20
申请号：US14831678
申请日：2015-08-20
Applicant: ABBOTT MEDICAL OPTICS INC.
Inventor： Stanley W. Huth , Denise Tran
CPC classification number: A61B3/101 , A61B3/0025 , A61B3/1005 , G01B11/06 , G01J3/45
Abstract: A method for determining reflectivity of a tear film lipid layer of a patient and recommending a course of treatment based on the same. The method includes the steps of: measuring a tear film aqueous plus lipid layer relative reflectance spectrum using a wavelength-dependent optical interferometer; converting the measured tear film aqueous plus lipid layer relative reflectance spectrum to a calculated absolute reflectance spectrum; comparing the calculated absolute reflectance spectrum to a theoretical absolute lipid reflectance spectrum to determine a tear film lipid layer thickness; and determining a reflectivity value for the tear film lipid layer thickness at a first wavelength of light corresponding to ultraviolet, violet, or blue light.
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公开(公告)号：US20140275274A1
公开(公告)日：2014-09-18
申请号：US13826257
申请日：2013-03-14
Applicant: ABBOTT MEDICAL OPTICS INC.
Inventor： Stanley W. Huth , Denise Tran
IPC: A61K31/155 , A01N37/52
CPC classification number: A61K31/155 , A01N37/52 , A61L12/14 , A61L12/141 , A61L12/145
Abstract: Compositions and methods for disinfecting contact lenses using the compositions are disclosed. The compositions include a combination of alexidine and chlorhexidine, which surprisingly causes the composition to exhibit synergistic antimicrobial activity against Candida albicans by reducing a concentration of Candida albicans by at least 1.2 log.
Abstract translation: 公开了使用该组合物消毒隐形眼镜的组合物和方法。 组合物包括阿维膦酸和氯己定的组合，令人惊奇的是通过将白色念珠菌的浓度降低至少1.2log，使组合物对白色念珠菌显示出协同的抗微生物活性。
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公开(公告)号：US20130208246A1
公开(公告)日：2013-08-15
申请号：US13755295
申请日：2013-01-31
Applicant: Abbott Medical Optics Inc.
Inventor： Stanley W. Huth , Denise Tran
IPC: A61B3/10
CPC classification number: A61B3/101
Abstract: Methods and devices measure eye blinks and tear film lipid and aqueous layer thickness before and following ophthalmic formula application onto the ocular surface, especially wherein the ophthalmic formula is an artificial tear. The methods and devices are suitable for dry eye diagnosis. The methods and devices are suitable for use to evaluate ophthalmic formula effects on the tear film and to use such information to diagnose ophthalmic formula treatment of ocular disease conditions such as dry eye in the absence of contact lens wear or post-surgical eye drop treatment and diagnosis. The methods and devices are also suitable for use in the optimization of ophthalmic drug dosage forms and sustained drug release.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20170280991A1
公开(公告)日：2017-10-05
申请号：US15625815
申请日：2017-06-16
Applicant: ABBOTT MEDICAL OPTICS INC.
Inventor： Stanley W. Huth , Denise Tran
CPC classification number: A61B3/101 , A61B3/0025 , A61B3/1005 , G01B11/06 , G01J3/45
Abstract: A method for determining reflectivity of a tear film lipid layer of a patient and recommending a course of treatment based on the same. The method includes the steps of: measuring a tear film aqueous plus lipid layer relative reflectance spectrum using a wavelength-dependent optical interferometer; converting the measured tear film aqueous plus lipid layer relative reflectance spectrum to a calculated absolute reflectance spectrum; comparing the calculated absolute reflectance spectrum to a theoretical absolute lipid reflectance spectrum to determine a tear film lipid layer thickness; and determining a reflectivity value for the tear film lipid layer thickness at a first wavelength of light corresponding to ultraviolet, violet, or blue light.
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公开(公告)号：US20160345821A1
公开(公告)日：2016-12-01
申请号：US15172083
申请日：2016-06-02
Applicant: ABBOTT MEDICAL OPTICS INC.
Inventor： Stanley W. Huth , Denise Tran
CPC classification number: A61B3/0025 , A61B3/1005 , A61B3/101 , A61B3/103 , G01B9/02 , G01B11/06 , G01J3/45
Abstract: A method for determining optical properties of a corneal region. The method includes the steps of obtaining a combined tear film aqueous layer plus lipid layer thickness; obtaining a tear film lipid layer thickness; subtracting the tear film lipid layer thickness from the combined tear film aqueous layer plus lipid layer thickness to obtain a tear film aqueous layer thickness; and determining a corneal layer refractive index based on the tear film lipid layer thickness and the tear film aqueous layer thickness.
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8.发明申请FAST ABSOLUTE-REFLECTANCE METHOD FOR THE DETERMINATION OF TEAR FILM LIPID LAYER THICKNESS 有权用于确定薄膜脂肪层厚度的快速绝对反射方法公开(公告)号：US20150351628A1
公开(公告)日：2015-12-10
申请号：US14831678
申请日：2015-08-20
Applicant: ABBOTT MEDICAL OPTICS INC.
Inventor： Stanley W. Huth , Denise Tran
CPC classification number: A61B3/101 , A61B3/0025 , A61B3/1005 , G01B11/06 , G01J3/45
Abstract: A method for determining reflectivity of a tear film lipid layer of a patient and recommending a course of treatment based on the same. The method includes the steps of: measuring a tear film aqueous plus lipid layer relative reflectance spectrum using a wavelength-dependent optical interferometer; converting the measured tear film aqueous plus lipid layer relative reflectance spectrum to a calculated absolute reflectance spectrum; comparing the calculated absolute reflectance spectrum to a theoretical absolute lipid reflectance spectrum to determine a tear film lipid layer thickness; and determining a reflectivity value for the tear film lipid layer thickness at a first wavelength of light corresponding to ultraviolet, violet, or blue light.
Abstract translation: 一种用于确定患者的泪膜脂质层的反射率的方法，并且基于该方法推荐治疗过程。 该方法包括以下步骤：使用波长相关的光学干涉仪测量泪膜水相加脂质层相对反射光谱; 将测量的泪膜水相加脂质层相对反射光谱转换为计算的绝对反射光谱; 将计算的绝对反射光谱与理论绝对脂质反射光谱进行比较以确定泪膜脂质层厚度; 以及确定在对应于紫外线，紫色或蓝色光的第一波长的泪膜脂质层厚度的反射率值。
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公开(公告)号：US09132106B2
公开(公告)日：2015-09-15
申请号：US13826257
申请日：2013-03-14
Applicant: Abbott Medical Optics Inc.
Inventor： Stanley W. Huth , Denise Tran
IPC: A61K31/155 , A01N37/52 , A61L12/14
CPC classification number: A61K31/155 , A01N37/52 , A61L12/14 , A61L12/141 , A61L12/145
Abstract: Compositions and methods for disinfecting contact lenses using the compositions are disclosed. The compositions include a combination of alexidine and chlorhexidine, which surprisingly causes the composition to exhibit synergistic antimicrobial activity against Candida albicans by reducing a concentration of Candida albicans by at least 1.2 log.
Abstract translation: 公开了使用该组合物消毒隐形眼镜的组合物和方法。 组合物包括阿维膦酸和氯己定的组合，令人惊奇的是通过将白色念珠菌的浓度降低至少1.2log，使组合物对白色念珠菌显示出协同的抗微生物活性。
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公开(公告)号：US20140161904A1
公开(公告)日：2014-06-12
申请号：US14183078
申请日：2014-02-18
Applicant: Abbott Medical Optics Inc.
Inventor： Stanley W. Huth , Simon Kilvington , Simon Cheung
CPC classification number: A01N59/16 , A01N37/34 , A01N47/40 , A01N59/08 , A61L12/088 , A61L12/141 , A61L12/145 , A61L2202/122
Abstract: Disclosed herein are ophthalmic cleaning systems and methods for their use, which comprise an ophthalmic solution and lens case, wherein the solution includes dual disinfectants and the lens case includes silver. When the lens case is combined with the solution according to the system of the present invention, it surprisingly exhibits synergistic activity which results in a faster antimicrobial activity.
Abstract translation: 本文公开了眼用清洁系统及其使用方法，其包括眼用溶液和透镜壳，其中所述溶液包括双重消毒剂，并且所述透镜壳包括银。 当透镜盒与根据本发明的系统的溶液组合时，令人惊奇地表现出协同的活性，这导致更快的抗微生物活性。
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