公开(公告)号：US09303001B2

公开(公告)日：2016-04-05

申请号：US14119448

申请日：2012-07-19

Applicant: Shouhua Zhang ,  Zhongqing Wang ,  Zhonghua Luo

Inventor： Shouhua Zhang ,  Zhongqing Wang ,  Zhonghua Luo

IPC: C07D257/04 ,  C07D319/06 ,  C07D405/12 ,  C07F7/18 ,  C07B53/00

CPC classification number: C07D257/04 ,  C07B53/00 ,  C07D319/06 ,  C07D405/12 ,  C07F7/1804

Abstract: The present invention relates to the field of pharmaceutical chemistry, specifically relates to a statin intermediate having formula I and preparation thereof. The advantages of the method used to prepare the chiral sulfone intermediate having formula I are that a fluorophore is introduced at the beginning of the synthesis, and the intermediates are mostly solid, which enables quality control to be easily carried out.

Abstract translation: 本发明涉及药物化学领域，具体涉及具有式I及其制备的他汀类中间体。 用于制备具有式I的手性砜中间体的方法的优点是在合成开始时引入荧光团，并且中间体大多是固体，这使得能够容易地进行质量控制。