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    Micro-fabrication of bio-degradable polymeric implants
    3.
    发明申请
    Micro-fabrication of bio-degradable polymeric implants 审中-公开
    生物可降解聚合物植入物的微制造

    公开(公告)号：US20060226575A1

    公开(公告)日：2006-10-12

    申请号：US11100751

    申请日：2005-04-07

    申请人： Mariam Maghribi ,  Zara Sieh

    发明人： Mariam Maghribi ,  Zara Sieh

    IPC分类号： B29C41/02 ,  B29C59/02 ,  B29C71/02 ,  B28B11/08 ,  B28B7/14 ,  B29C71/00

    CPC分类号： A61K9/0097 ,  A61K9/0009 ,  B29C41/003 ,  B29K2105/0035

    摘要： Various methods of micro-fabricating 2-dimensional and 3-dimensional medical devices comprised of bio-degradable materials. The various methods use conventional photo-lithographic techniques commonly used in the semi-conductor or integrated circuit industry and translate those techniques to process bio-degradable medical devices. The devices may be active, passive or combination active-passive devices for controlling the release of drugs or other bio-active agents contained within the devices. Such devices may be used externally or internally for drug delivery, wound healing, tissue re-generation or the like.

    摘要翻译： 由生物降解材料组成的微观制造二维和三维医疗器械的各种方法。 各种方法使用通常用于半导体或集成电路工业中的常规光刻技术，并将这些技术转化为生物降解医疗器件。 这些装置可以是主动的，被动的或组合的主动 - 被动装置，用于控制装置中所含的药物或其他生物活性剂的释放。 这样的装置可以在外部或内部用于药物递送，伤口愈合，组织再生等。

    Thin-film nitinol based drug eluting stent
    6.
    发明申请
    Thin-film nitinol based drug eluting stent 审中-公开
    薄膜镍钛诺基药物洗脱支架

    公开(公告)号：US20070173787A1

    公开(公告)日：2007-07-26

    申请号：US11264582

    申请日：2005-11-01

    申请人： Mark Huang ,  Scott McHugo ,  Anurag Mairal ,  Zara Sieh

    发明人： Mark Huang ,  Scott McHugo ,  Anurag Mairal ,  Zara Sieh

    IPC分类号： A61K9/22

    CPC分类号： A61F2/82 ,  A61F2250/0067

    摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. These devices may also comprise thin films that perform a number of functions. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

    摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 药物，药剂和/或化合物也可用于治疗特定疾病，包括易损斑块。 治疗剂也可以递送到疾病部位的区域。 在区域递送中，液体制剂可能是期望的，以增加特定药物的功效和递送能力。 此外，可以修改装置以促进内皮化。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。 此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。 医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。 这些装置还可以包括执行多个功能的薄膜。 此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

    Medical Device Mechanical Pump
    9.
    发明申请
    Medical Device Mechanical Pump 审中-公开
    医疗器械机械泵

    公开(公告)号：US20090247982A1

    公开(公告)日：2009-10-01

    申请号：US12407173

    申请日：2009-03-19

    申请人： Peter Krulevitch ,  Robert Wilk ,  Sean O'Connor ,  Mingqi Zhao ,  Zara Sieh ,  Donna Savage

    发明人： Peter Krulevitch ,  Robert Wilk ,  Sean O'Connor ,  Mingqi Zhao ,  Zara Sieh ,  Donna Savage

    IPC分类号： A61M1/00 ,  H04Q5/22

    CPC分类号： A61M5/14248 ,  A61M5/14224 ,  A61M5/1424 ,  A61M5/38 ,  A61M2005/1405 ,  A61M2005/14252 ,  A61M2205/0294 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/825

    摘要： A medical device pump with a housing with a compartment for removably receiving a cartridge containing a therapeutic agent, a conduit configured to operatively provide a fluid flow path for therapeutic agent to exit from the cartridge, a user activated delivery button, a trigger mechanism, and a mechanical pump mechanism. The trigger mechanism, user activated delivery button and mechanical pump mechanism of the medical device pump are configured such that the trigger mechanism is activated by a user fully activating the user activated delivery button. Moreover, such full activation generates mechanical power employed by, and sufficient for, the mechanical pump mechanism to pump a predetermined volume of therapeutic agent from the cartridge and through the fluid flow path.

    摘要翻译： 一种具有壳体的医疗装置泵，具有用于可拆卸地容纳包含治疗剂的药筒的隔室，构造成可操作地提供用于治疗剂从药筒离开的流体流动路径的管道，用户激活的递送按钮，触发机构和 机械泵机构。 触发机构，用户激活的输送按钮和医疗装置泵的机械泵机构被配置为使得触发机构被用户激活，完全激活用户激活的递送按钮。 此外，这种完全激活产生机械功率，并且足以使机械泵机构从盒中泵送预定量的治疗剂并通过流体流动路径。

    FOCUSED ELECTROMAGNETIC-WAVE AND ULTRASONIC-WAVE STRUCTURES FOR TISSUE STIMULATION
    10.
    发明申请
    FOCUSED ELECTROMAGNETIC-WAVE AND ULTRASONIC-WAVE STRUCTURES FOR TISSUE STIMULATION 审中-公开
    用于组织刺激的聚焦电磁波和超声波结构

    公开(公告)号：US20080103558A1

    公开(公告)日：2008-05-01

    申请号：US11876192

    申请日：2007-10-22

    申请人： Stuart Wenzel ,  Zara Sieh

    发明人： Stuart Wenzel ,  Zara Sieh

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3787 ,  A61N1/36014 ,  A61N1/36017 ,  A61N1/36021 ,  A61N1/37229

    摘要： The present invention is directed to small, low profile, antenna-transmitter systems that attach to exterior of the body and focus electromagnetic (EM) wave energy onto one or more precise regions inside the body. The antenna-transmitter system may also deliver energy to the surface of the body without focusing. The present invention is further directed to a method of focusing energy, such as electromagnetic radiation, onto a single nerve to effect selective neurostimulation, super- or sub-threshold, using a small, low profile, antenna-transmitter system that attaches to the body exterior and focuses electromagnetic wave energy onto the nerve.

    摘要翻译： 本发明涉及附接到身体外部并将电磁（EM）波能量聚焦到身体内的一个或多个精确区域上的小型，薄型的天线 - 发射机系统。 天线发射机系统还可以将能量传递到身体的表面而不进行聚焦。 本发明还涉及一种将诸如电磁辐射的能量聚焦到单个神经上的方法，以使用附接到身体的小型，矮小型的天线 - 发射器系统来实现选择性神经刺激，超阈值或次阈值 将电磁波能量聚焦到神经上。