公开(公告)号：US20240327922A1

公开(公告)日：2024-10-03

申请号：US18268240

申请日：2021-12-17

申请人： Jiantao SHI ,  Zachary D. SMITH ,  Alexander MEISSNER ,  Franziska MICHOR ,  President and Fellows of Harvard College ,  DANA-FARBER CANCER INSTITUTE, INC.

发明人： Jiantao Shi ,  Zachary D. Smith ,  Alexander Meissner ,  Franziska Michor

IPC分类号： C12Q1/6886 ,  G16B20/10 ,  G16B40/20

CPC分类号： C12Q1/6886 ,  G16B20/10 ,  G16B40/20 ,  C12Q2600/154

摘要： The present invention relates to methods of characterizing cell-free DNA (cfDNA), detecting cancer, detecting the eradication of cancer, and determining a probability distribution of haplotypes. The methods use the data from genomic sequences from CpG Islands (CGI) methylated in the genome of extraembryonic ectoderm (ExE) to determine a proportion of fully methylated haplotypes in order to characterize the cfDNA sample and detect certain cancers.