发明公开
- 专利标题： METHODS OF CANCER DETECTION USING EXTRAEMBRYONICALLY METHYLATED CPG ISLANDS
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申请号： US18268240申请日： 2021-12-17
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公开(公告)号： US20240327922A1公开(公告)日： 2024-10-03
- 发明人: Jiantao Shi , Zachary D. Smith , Alexander Meissner , Franziska Michor
- 申请人： Jiantao SHI , Zachary D. SMITH , Alexander MEISSNER , Franziska MICHOR , President and Fellows of Harvard College , DANA-FARBER CANCER INSTITUTE, INC.
- 申请人地址： US MA Jamaica Plain
- 专利权人： Jiantao SHI,Zachary D. SMITH,Alexander MEISSNER,Franziska MICHOR,President and Fellows of Harvard College,DANA-FARBER CANCER INSTITUTE, INC.
- 当前专利权人： Jiantao SHI,Zachary D. SMITH,Alexander MEISSNER,Franziska MICHOR,President and Fellows of Harvard College,DANA-FARBER CANCER INSTITUTE, INC.
- 当前专利权人地址： US MA Jamaica Plain
- 国际申请： PCT/US2021/064210 2021.12.17
- 进入国家日期： 2023-06-18
- 主分类号： C12Q1/6886
- IPC分类号： C12Q1/6886 ; G16B20/10 ; G16B40/20
摘要：
The present invention relates to methods of characterizing cell-free DNA (cfDNA), detecting cancer, detecting the eradication of cancer, and determining a probability distribution of haplotypes. The methods use the data from genomic sequences from CpG Islands (CGI) methylated in the genome of extraembryonic ectoderm (ExE) to determine a proportion of fully methylated haplotypes in order to characterize the cfDNA sample and detect certain cancers.
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