公开(公告)号：US20110251387A1

公开(公告)日：2011-10-13

申请号：US13140640

申请日：2009-12-24

Applicant: Jaeheon Lee ,  Gha-Seung Park ,  Jin Hee Kim ,  Ji Eun Lee ,  Chul Hyun Park ,  Tae Jin Choi ,  Eun-Ju Park ,  Cheol Kyung Kim ,  Eun Jung Lim ,  Young-Kil Chang ,  Gwan Sun Lee

Inventor： Jaeheon Lee ,  Gha-Seung Park ,  Jin Hee Kim ,  Ji Eun Lee ,  Chul Hyun Park ,  Tae Jin Choi ,  Eun-Ju Park ,  Cheol Kyung Kim ,  Eun Jung Lim ,  Young-Kil Chang ,  Gwan Sun Lee

IPC: C07D473/18 ,  C07F7/08 ,  C07C49/517

CPC classification number: C07D473/18

Abstract: The present invention relates to a novel, high-yield and low-cost method for preparing entecavir, [1-S-(1α,3α,4β)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one, an antiviral agent, and novel intermediates used therein.

Abstract translation: 本发明涉及一种制备恩替卡韦[1-S-（1α，3α，4α] b] -2-氨基-1,9-二氢-9- [4- 羟基-3-（羟甲基）-2-亚甲基环戊基] -6H-嘌呤-6-酮，抗病毒剂及其中使用的新型中间体。

公开(公告)号：US07858761B2

公开(公告)日：2010-12-28

申请号：US11572790

申请日：2005-06-21

Applicant: Jaeheon Lee ,  Gha-Seung Park ,  Moonsub Lee ,  Han Kyong Kim ,  Hyo-Jeong Bang ,  Young-Kil Chang ,  Gwan Sun Lee

Inventor： Jaeheon Lee ,  Gha-Seung Park ,  Moonsub Lee ,  Han Kyong Kim ,  Hyo-Jeong Bang ,  Young-Kil Chang ,  Gwan Sun Lee

IPC: C07H23/00 ,  C07H11/04 ,  C07H5/02

CPC classification number: C07H3/08

Abstract: 1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) having the 3-hydroxy group protected with a biphenylcarbonyl group is a solid which can be easily purified by a simple procedure such as recrystallization, and therefore, it can be advantageously used as an intermediate in the preparation of gemcitabine in a large scale. Further, the 1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) can be prepared with high stereoselectivity using the compound of formula (V) as an intermediate.

Abstract translation: 具有用联苯基羰基保护的3-羟基的式（I）的1-α-卤代-2,2-二氟-2-脱氧-D-呋喃核糖衍生物是可以通过简单的方法容易地纯化的固体，例如 重结晶，因此可以有利地用作大量制备吉西他滨的中间体。 此外，式（I）的1-α-卤代-2,2-二氟-2-脱氧-D-呋喃核糖衍生物可以使用式（V）化合物作为中间体以高立体选择性制备。

公开(公告)号：US20100274029A1

公开(公告)日：2010-10-28

申请号：US12740827

申请日：2008-10-29

Applicant: Sang Min Yun ,  Young Ho Moon ,  Young-Kil Chang ,  Dong Jin Hong ,  Ji-Yeon Chang ,  Moon Sub Lee ,  Jaeho Yoo ,  Ji Sook Kim ,  Cheol Kyung Kim

Inventor： Sang Min Yun ,  Young Ho Moon ,  Young-Kil Chang ,  Dong Jin Hong ,  Ji-Yeon Chang ,  Moon Sub Lee ,  Jaeho Yoo ,  Ji Sook Kim ,  Cheol Kyung Kim

IPC: C07D309/30 ,  C07C229/00

CPC classification number: C07D309/32 ,  C07C249/02 ,  C07C251/08 ,  C07F7/1804 ,  Y02P20/55

Abstract: Provided is a method of preparing a (6R)-3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one, and a (5R)-2-hexyl-5-hydroxy-3-iminohexadecanoate derivative used in said method as an intermediate.

Abstract translation: 提供制备（6R）-3-己基-4-羟基-6-十一烷基-5,6-二氢吡喃-2-酮和（5R）-2-己基-5-羟基-3-亚氨基十六酸酯的方法 所述方法中使用的衍生物作为中间体。

公开(公告)号：US20100099876A1

公开(公告)日：2010-04-22

申请号：US12518213

申请日：2007-12-11

Applicant: Gwan Sun Lee ,  Young-Kil Chang ,  Jaeheon Lee ,  Chul Hyun Park ,  Eun-Ju Park ,  Jaeho Yoo

Inventor： Gwan Sun Lee ,  Young-Kil Chang ,  Jaeheon Lee ,  Chul Hyun Park ,  Eun-Ju Park ,  Jaeho Yoo

IPC: C07D215/18 ,  C07F9/09

CPC classification number: C07D215/18

Abstract: The present invention relates to a method for preparing montelukast, an inhibitor against leukotrienes, and an intermediate used therein. According to the inventive method, high-purity montelukast or its sodium salt can be prepared in a high yield.

Abstract translation: 本发明涉及一种制备孟鲁司特，抑制白三烯的方法及其中使用的中间体。 根据本发明的方法，可以高产率制备高纯度孟鲁司特或其钠盐。

公开(公告)号：US07638642B2

公开(公告)日：2009-12-29

申请号：US11572404

申请日：2005-06-23

Applicant: Jaeheon Lee ,  Gha-Seung Park ,  Moonsub Lee ,  Cheol-Kyong Kim ,  Jae-Chul Lee ,  Young-Kil Chang ,  Gwan-Sun Lee

Inventor： Jaeheon Lee ,  Gha-Seung Park ,  Moonsub Lee ,  Cheol-Kyong Kim ,  Jae-Chul Lee ,  Young-Kil Chang ,  Gwan-Sun Lee

IPC: C07D307/02

CPC classification number: C07H3/08

Abstract: 3R-carboxylate enantiomer derivative of formula (III) can be prepared easily and selectively by the method of the present invention, and a highly pure D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative can be prepared efficiently from the compound of formula (III) as an intermediate.

Abstract translation: 可以通过本发明的方法容易地和选择性地制备式（III）的3R-羧酸酯对映异构体衍生物，并且可以有效地制备高纯度的D-赤式-2,2-二氟-2-脱氧-1-氧代果糖衍生物 由作为中间体的式（III）化合物制备。

公开(公告)号：US07112672B2

公开(公告)日：2006-09-26

申请号：US10475057

申请日：2002-04-17

Applicant: Gwan-Sun Lee ,  Young-Kil Chang ,  Hong-Sun Kim ,  Jae-Heon Lee ,  Chul-Hyun Park ,  Gha-Seung Park ,  Cheol-Kyung Kim

Inventor： Gwan-Sun Lee ,  Young-Kil Chang ,  Hong-Sun Kim ,  Jae-Heon Lee ,  Chul-Hyun Park ,  Gha-Seung Park ,  Cheol-Kyung Kim

IPC: C07D501/22

CPC classification number: C07D501/00 ,  Y02P20/55

Abstract: A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephem compound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl protecting group; R1 is hydrogen or R2CH2CO—; and R2 is ethyl, 2-thiophenyl, phenyl, p-hydroxyphenyl or phenoxy

Abstract translation: 通过在碱存在下将亚正膦基头孢烯化合物与乙醛反应在包含二乙醚，式（I）的溶剂混合物中，其中R是羧基保护基，选择性地制备3-（Z） - 丙烯基头孢烯化合物。 R 1是氢或R 2 CH 2 CO-; R 2是乙基，2-噻吩基，苯基，对羟基苯基或苯氧基

公开(公告)号：US07038050B2

公开(公告)日：2006-05-02

申请号：US10526158

申请日：2004-07-19

Applicant: Young Ho Moon ,  Dong Jun Kim ,  Chul-Hyun Park ,  Kyung Ik Lee ,  Jae-Cheol Lee ,  Gwan Sun Lee ,  Young-Kil Chang

Inventor： Young Ho Moon ,  Dong Jun Kim ,  Chul-Hyun Park ,  Kyung Ik Lee ,  Jae-Cheol Lee ,  Gwan Sun Lee ,  Young-Kil Chang

IPC: C07D221/18 ,  C07D221/02

CPC classification number: C07J43/00

Abstract: A method for preparing a 1-androstene derivative which comprises reacting a 2-iodo-androstane derivative with an oxidizing agent while maintaining the pH of the reaction mixture at a specific range gives the 1-androstene derivative with high purity and yield.

Abstract translation: 制备1-雄甾烯衍生物的方法，其包括使2-碘 - 雄甾烷衍生物与氧化剂反应，同时将反应混合物的pH保持在特定范围，得到高纯度和产率的1-雄甾烯衍生物。

公开(公告)号：US06646032B2

公开(公告)日：2003-11-11

申请号：US10011056

申请日：2001-12-06

Applicant: Bok-nam Jang ,  Se-jong Kim ,  Gyu-cheol Lee ,  Young-kil Chang ,  Byeong-do Lee ,  Jung-hyun Kim

Inventor： Bok-nam Jang ,  Se-jong Kim ,  Gyu-cheol Lee ,  Young-kil Chang ,  Byeong-do Lee ,  Jung-hyun Kim

IPC: C08K552

CPC classification number: C08L51/04 ,  C08F279/02 ,  C08K5/521 ,  C08K5/523 ,  C08L55/02 ,  C08L71/123 ,  C08L81/02 ,  C08L2666/14 ,  C08L2666/02 ,  C08L85/00

Abstract: A flameproof thermoplastic resin composition of the present invention comprises (A) a base resin comprising 40 to 95% by weight of a rubber modified styrene-containing resin (a1) composed of 20 to 100% by weight of a styrene-containing graft copolymer resin (a11) and 0 to 80% by weight of a styrene-containing copolymer resin (a12), and 60 to 5% by weight of polyphenylene ether resin (a2); (B) 2 to 40 parts by weight of a styrene-acrylonitrile copolymer containing 5 to 18% by weight of acrylonitrile per 100 parts by weight of the base resin; (C) 5 to 30 parts by weight of an aromatic phosphoric acid ester compound having a melting point of more than 90° C. per 100 parts by weight of the base resin; and (D) 3 to 30 parts by weight of a phenolic resin per 100 parts by weight of the base resin. The flameproof thermoplastic resin composition may further comprise 0 to 30 parts by weight of an anti-dripping agent, an impact modifier, a plasticizer, a heat stabilizer, an oxidation inhibitor, a light stabilizer, a compatibilizer, pigments, dyes and/or inorganic fillers on the basis of 100 parts by weight of the base resin.

公开(公告)号：US06639068B1

公开(公告)日：2003-10-28

申请号：US10111557

申请日：2002-04-24

Applicant: Gwan-Sun Lee ,  Young-Kil Chang ,  Jae-Heon Lee ,  Chul-Hyun Park ,  Gha-Seung Park ,  Keum-Shin Jung

Inventor： Gwan-Sun Lee ,  Young-Kil Chang ,  Jae-Heon Lee ,  Chul-Hyun Park ,  Gha-Seung Park ,  Keum-Shin Jung

IPC: C07D50134

CPC classification number: C07D501/00

Abstract: Highly pure cefpodoxime proxetil can be prepared by a simple process comprising the step of reacting a cefpodoxime salt with 1-iodoethylisopropylcarbonate in an organic solvent in the presence of a crown ether.

Abstract translation: 高纯度头孢泊肟原料可以通过简单的方法制备，包括在冠醚存在下，使头孢泊肟盐与1-碘乙基异丙基碳酸酯在有机溶剂中反应的步骤。

公开(公告)号：US08853213B2

公开(公告)日：2014-10-07

申请号：US13997415

申请日：2011-12-29

Applicant: Jung Beom Son ,  Nam Du Kim ,  Young Kil Chang ,  Hee Cheol Kim ,  Ji Sook Kim ,  Young Hee Jung

Inventor： Jung Beom Son ,  Nam Du Kim ,  Young Kil Chang ,  Hee Cheol Kim ,  Ji Sook Kim ,  Young Hee Jung

IPC: A61K31/7024 ,  C07D495/04 ,  C07D487/04

CPC classification number: C07D495/04 ,  C07D487/04

Abstract: The present invention relates to a bicyclic compound for modulating G protein-coupled receptors. The inventive compound provides preventing or treating a disease associated with the modulation of G protein-coupled receptors, particularly GPR119 G protein-coupled receptors.

Abstract translation: 本发明涉及用于调节G蛋白偶联受体的双环化合物。 本发明化合物提供预防或治疗与G蛋白偶联受体，特别是GPR119G蛋白偶联受体的调节相关的疾病。