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公开(公告)号:US08865078B2
公开(公告)日:2014-10-21
申请号:US12805411
申请日:2010-07-29
申请人: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
发明人: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
IPC分类号: G01N21/00 , G01N21/01 , G01N21/64 , G01N33/50 , G01N33/52 , G01N33/487 , C40B60/12 , B82Y15/00 , G01N21/77
CPC分类号: G01N21/6486 , B82Y15/00 , G01N21/645 , G01N21/648 , G01N21/7703 , G01N33/54373 , G01N2021/6482 , G01N2021/6484 , G01N2201/088 , Y10S977/954 , Y10S977/957 , Y10S977/958 , Y10T436/143333 , Y10T436/145555
摘要: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
摘要翻译: 一种用于检测能够发光的物体的装置。 该装置包括光源和波导。 波导包括芯层和第一覆层。 在至少第一包层中形成至少一个纳米线。 该装置还包括光检测器。 光检测器可以检测从包含在至少一个纳米管中的单个分子对象发射的光。
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公开(公告)号:US20120112219A1
公开(公告)日:2012-05-10
申请号:US12939800
申请日:2010-11-04
申请人: Guang-Way Jang , Ying-Chih Pu , Yin-Ju Yang , Chang-Ming Wong , Chih-Fen Chang
发明人: Guang-Way Jang , Ying-Chih Pu , Yin-Ju Yang , Chang-Ming Wong , Chih-Fen Chang
IPC分类号: H01L33/50 , C08K5/205 , C08K5/5425 , H01B1/14 , C09K5/00 , F21V31/04 , C08J3/28 , C08J3/20 , B82Y20/00 , B82Y99/00
CPC分类号: B82Y30/00 , B82Y20/00 , C08J5/005 , C08J2300/00 , H01L33/508 , H01L2933/0041 , H01L2933/005
摘要: Method of manufacturing gradient composite material comprises steps of providing plural surface modified inorganic nanoparticles with functional groups or oligomers with functional groups; transferring the surface modified inorganic nanoparticles or oligomers with functional groups into an organic matrix to form a mixture; performing a photo polymerization step or a thermo-polymerization step for polymerizing and generating a gradient distribution of the surface modified inorganic nanoparticles or oligomers with functional groups in the mixture; and curing the mixture to solidify the organic matrix and form a structure with gradient composite, wherein the organic matrix is transferred into an organic polymer after curing.
摘要翻译: 制备梯度复合材料的方法包括以下功能性基团的功能基团或低聚物提供多个表面改性的无机纳米粒子的步骤; 将表面改性的无机纳米颗粒或具有官能团的低聚物转移到有机基质中以形成混合物; 进行光聚合步骤或热聚合步骤,用于聚合并产生表面改性的无机纳米颗粒或低聚物与该混合物中的官能团的梯度分布; 并固化混合物以固化有机基质并形成具有梯度复合材料的结构,其中有机基质在固化后转移到有机聚合物中。
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公开(公告)号:US08721969B2
公开(公告)日:2014-05-13
申请号:US12801503
申请日:2010-06-11
申请人: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
发明人: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
摘要: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
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公开(公告)号:US20110306143A1
公开(公告)日:2011-12-15
申请号:US12805411
申请日:2010-07-29
申请人: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
发明人: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
CPC分类号: G01N21/6486 , B82Y15/00 , G01N21/645 , G01N21/648 , G01N21/7703 , G01N33/54373 , G01N2021/6482 , G01N2021/6484 , G01N2201/088 , Y10S977/954 , Y10S977/957 , Y10S977/958 , Y10T436/143333 , Y10T436/145555
摘要: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
摘要翻译: 一种用于检测能够发光的物体的装置。 该装置包括光源和波导。 波导包括芯层和第一覆层。 在至少第一包层中形成至少一个纳米线。 该装置还包括光检测器。 光检测器可以检测从包含在至少一个纳米管中的单个分子对象发射的光。
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公开(公告)号:US20110223590A1
公开(公告)日:2011-09-15
申请号:US13046457
申请日:2011-03-11
申请人: Chung-Fan CHIOU , Ying-Chih Pu , Chao-Chi Pan , Chih-Tsung Shih , Ming-Chia Li , Chein-Shiu Kuo , Hung-Chi Chien , Chang-Sheng Chu
发明人: Chung-Fan CHIOU , Ying-Chih Pu , Chao-Chi Pan , Chih-Tsung Shih , Ming-Chia Li , Chein-Shiu Kuo , Hung-Chi Chien , Chang-Sheng Chu
CPC分类号: C12Q1/6869 , G01N21/6428 , G01N21/6452 , G01N21/6454 , G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2201/08 , G01N2201/12 , C12Q2563/155 , C12Q2561/113
摘要: Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.
摘要翻译: 实施例包括单分子检测系统和使用检测系统检测物体的方法。 此外,实施例包括包括可移动光耦合器,波导和光检测器的检测系统。 实施方案进一步包括单分子检测的方法,包括单分子核酸测序的方法。
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公开(公告)号:US09482615B2
公开(公告)日:2016-11-01
申请号:US13046457
申请日:2011-03-11
申请人: Chung-Fan Chiou , Ying-Chih Pu , Chao-Chi Pan , Chih-Tsung Shih , Ming-Chia Li , Chein-Shiu Kuo , Hung-Chi Chien , Chang-Sheng Chu
发明人: Chung-Fan Chiou , Ying-Chih Pu , Chao-Chi Pan , Chih-Tsung Shih , Ming-Chia Li , Chein-Shiu Kuo , Hung-Chi Chien , Chang-Sheng Chu
CPC分类号: C12Q1/6869 , G01N21/6428 , G01N21/6452 , G01N21/6454 , G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2201/08 , G01N2201/12 , C12Q2563/155 , C12Q2561/113
摘要: Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.
摘要翻译: 实施例包括单分子检测系统和使用检测系统检测物体的方法。 此外,实施例包括包括可移动光耦合器,波导和光检测器的检测系统。 实施方案进一步包括单分子检测的方法,包括单分子核酸测序的方法。
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公开(公告)号:US08865077B2
公开(公告)日:2014-10-21
申请号:US12801503
申请日:2010-06-11
申请人: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
发明人: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
IPC分类号: G01N33/487 , G01N33/50 , G01N33/52 , G01N21/01 , G01N21/64 , C40B60/12 , G01J1/04 , G01J1/58 , G02B6/34 , C12Q1/68
CPC分类号: G01J1/58 , C12Q1/68 , C12Q1/6869 , C12Q1/6874 , G01J1/0425 , G02B6/34 , Y10S977/954 , Y10S977/957 , Y10S977/958 , C12Q2563/103 , C12Q2565/607
摘要: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
摘要翻译: 一种用于检测能够发光的物体的装置。 该装置包括光源和波导。 波导包括芯层和第一覆层。 在至少第一包层中形成至少一个纳米线。 该装置还包括光检测器。 光检测器可以检测从包含在至少一个纳米管中的单个分子对象发射的光。
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公开(公告)号:US08368106B2
公开(公告)日:2013-02-05
申请号:US12939800
申请日:2010-11-04
申请人: Guang-Way Jang , Ying-Chih Pu , Yin-Ju Yang , Chang-Ming Wong , Chih-Fen Chang
发明人: Guang-Way Jang , Ying-Chih Pu , Yin-Ju Yang , Chang-Ming Wong , Chih-Fen Chang
CPC分类号: B82Y30/00 , B82Y20/00 , C08J5/005 , C08J2300/00 , H01L33/508 , H01L2933/0041 , H01L2933/005
摘要: Method of manufacturing gradient composite material comprises steps of providing plural surface modified inorganic nanoparticles with functional groups or oligomers with functional groups; transferring the surface modified inorganic nanoparticles or oligomers with functional groups into an organic matrix to form a mixture; performing a photo polymerization step or a thermo-polymerization step for polymerizing and generating a gradient distribution of the surface modified inorganic nanoparticles or oligomers with functional groups in the mixture; and curing the mixture to solidify the organic matrix and form a structure with gradient composite, wherein the organic matrix is transferred into an organic polymer after curing.
摘要翻译: 制备梯度复合材料的方法包括以下功能性基团的功能基团或低聚物提供多个表面改性的无机纳米粒子的步骤; 将表面改性的无机纳米颗粒或具有官能团的低聚物转移到有机基质中以形成混合物; 进行光聚合步骤或热聚合步骤,用于聚合并产生表面改性的无机纳米颗粒或低聚物与该混合物中的官能团的梯度分布; 并固化混合物以固化有机基质并形成具有梯度复合材料的结构,其中有机基质在固化后转移到有机聚合物中。
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公开(公告)号:US20110306039A1
公开(公告)日:2011-12-15
申请号:US12801503
申请日:2010-06-11
申请人: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
发明人: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
CPC分类号: G01J1/58 , C12Q1/68 , C12Q1/6869 , C12Q1/6874 , G01J1/0425 , G02B6/34 , Y10S977/954 , Y10S977/957 , Y10S977/958 , C12Q2563/103 , C12Q2565/607
摘要: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
摘要翻译: 一种用于检测能够发光的物体的装置。 该装置包括光源和波导。 波导包括芯层和第一覆层。 在至少第一包层中形成至少一个纳米线。 该装置还包括光检测器。 光检测器可以检测从包含在至少一个纳米管中的单个分子对象发射的光。
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