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    Un-supported polymeric film with embedded microbeads
    1.
    发明授权
    Un-supported polymeric film with embedded microbeads 有权
    具有嵌入微珠的未负载的聚合物膜

    公开(公告)号：US09436088B2

    公开(公告)日：2016-09-06

    申请号：US11761789

    申请日：2007-06-12

    申请人： Michael Seul ,  Sukanta Banerjee ,  Kairali Podual ,  Ye Hong

    发明人： Michael Seul ,  Sukanta Banerjee ,  Kairali Podual ,  Ye Hong

    IPC分类号： G01N33/553 ,  G03F7/16 ,  G03F7/004

    CPC分类号： C08J3/075 ,  C08J3/28 ,  C08J2333/26 ,  C08J2425/06 ,  C12Q1/6837 ,  G01N33/5005 ,  G01N33/545 ,  G03F7/0047 ,  G03F7/164 ,  Y10T428/249952 ,  Y10T428/25

    摘要： The present invention relates to polymer-bead composites having a single layer planar, crystalline assembly of encoded beads embedded in a hydrophilic polymeric matrix. The composite may be unattached to a solid support. The encoded beads have different biomolecules attached to their surfaces, and the encoding permits distinguishing beads having different biomolecules attached thereto. The present invention also relates to a systematic process for the creation of functionally organized, spatially patterned assemblies of polymer-microparticle composites, including the AC electric field-mediated assembly of patterned, self-supporting organic (polymeric) films and organic-polymer-microparticle composites of tailored composition and morphology. The present invention also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, and micro-reactors, and miniaturized format for generation of multifunctional thin films.

    摘要翻译： 本发明涉及具有嵌入亲水性聚合物基质中的编码珠粒的单层平面结晶组合物的聚合物 - 珠复合物。 复合材料可能不附着在固体支撑物上。 编码的珠粒具有连接到其表面的不同生物分子，并且编码允许区分附着有不同生物分子的珠粒。 本发明还涉及一种用于创建聚合物 - 微粒复合材料的功能组织的空间图案化组件的系统方法，包括图案化的自支撑有机（聚合物）膜和有机 - 聚合物 - 微粒的AC电场介导装配 定制组合和形态的复合材料。 本发明还涉及这种功能组件在材料科学和生物学中的应用。 其他应用领域包括传感器，催化剂，膜和微反应器以及用于产生多功能薄膜的小型化形式。

    Silicone hydrogel contact lenses
    2.
    发明授权
    Silicone hydrogel contact lenses 有权
    硅胶水凝胶隐形眼镜

    公开(公告)号：US09296159B2

    公开(公告)日：2016-03-29

    申请号：US13983306

    申请日：2012-02-23

    申请人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

    发明人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

    IPC分类号： G02B1/04 ,  B29D11/00 ,  C08F290/06

    CPC分类号： B29D11/00125 ,  B29D11/0025 ,  C08F290/068 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

    摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer, or at least one hydrophilic vinyl ether-containing monomer, or both, wherein, when the at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, and when the at least one hydrophilic vinyl ether-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

    摘要翻译： 衍生自包含至少一种硅氧烷单体和至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体或至少一种亲水乙烯基醚的单体或两者的可聚合组合物的硅氧烷水凝胶隐形眼镜，其中当在 在可聚合组合物中存在至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体，其存在量为1至20单位份重量，并且当至少一种亲水乙烯基醚单体存在于 可聚合组合物的含量为1〜20单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

    Silicone Hydrogel Contact Lenses
    3.
    发明申请
    Silicone Hydrogel Contact Lenses 有权
    硅胶水凝胶隐形眼镜

    公开(公告)号：US20140009735A1

    公开(公告)日：2014-01-09

    申请号：US13983306

    申请日：2012-02-23

    申请人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

    发明人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

    IPC分类号： G02B1/04 ,  B29D11/00

    CPC分类号： B29D11/00125 ,  B29D11/0025 ,  C08F290/068 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

    摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer, or at least one hydrophilic vinyl ether-containing monomer, or both, wherein, when the at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, and when the at least one hydrophilic vinyl ether-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

    摘要翻译： 衍生自包含至少一种硅氧烷单体和至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体或至少一种亲水乙烯基醚的单体或两者的可聚合组合物的硅氧烷水凝胶隐形眼镜，其中当在 在可聚合组合物中存在至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体，其存在量为1至20单位份重量，并且当至少一种亲水乙烯基醚单体存在于 可聚合组合物的含量为1〜20单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

    Dimensionally Stable Silicone Hydrogel Contact Lenses
    4.
    发明申请
    Dimensionally Stable Silicone Hydrogel Contact Lenses 有权
    尺寸稳定的硅胶水凝胶隐形眼镜

    公开(公告)号：US20120220743A1

    公开(公告)日：2012-08-30

    申请号：US13404034

    申请日：2012-02-24

    申请人： Charles A. Francis ,  Ying Zheng ,  Yuan Xu ,  Li Yao ,  Arthur Back ,  Ye Hong ,  Charlie Chen

    发明人： Charles A. Francis ,  Ying Zheng ,  Yuan Xu ,  Li Yao ,  Arthur Back ,  Ye Hong ,  Charlie Chen

    IPC分类号： C08F230/08

    CPC分类号： C08F230/08 ,  C08F222/1006

    摘要： Dimensionally stable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer represented by formula (2): wherein R1 of formula (2) is selected from either hydrogen atom or a methyl group; R2 of formula (2) is selected from either of hydrogen atom or a hydrocarbon group having 1 to 4 carbon atoms; m of formula (2) represents an integer of from 0 to 10; n of formula (2) represents an integer of from 4 to 100; a and b represent integers of 1 or more; a+b is equal to 20-500; b/(a+b) is equal to 0.01-0.22; the configuration of siloxane units includes a random configuration, the second siloxane monomer having a number average molecular weight of at least 3,000 daltons that is present in the polymerizable composition in an amount such that ratio of the first siloxane monomer to the second siloxane monomer is at least 2:1 based on unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

    摘要翻译： 描述了尺寸稳定的硅酮水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自由式（2）表示的第二硅氧烷单体的单元：其中式（2）的R 1选自氢原子或甲基; 式（2）的R2选自氢原子或碳原子数为1〜4的烃基; 式（2）的m表示0〜10的整数， 式（2）的n表示4〜100的整数， a和b表示1以上的整数; a + b等于20-500; b /（a + b）等于0.01-0.22; 硅氧烷单元的构型包括随机构型，第二硅氧烷单体的数均分子量为至少3,000道尔顿，其存在于可聚合组合物中，其量使得第一硅氧烷单体与第二硅氧烷单体的比率在 至少2：1，单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

    Silicone Hydrogel Contact Lenses Having Acceptable Levels Of Energy Loss
    5.
    发明申请
    Silicone Hydrogel Contact Lenses Having Acceptable Levels Of Energy Loss 有权
    硅胶水凝胶接触透镜具有可接受的能量损失水平

    公开(公告)号：US20120220690A1

    公开(公告)日：2012-08-30

    申请号：US13404040

    申请日：2012-02-24

    申请人： Ronghua Liu ,  Xinfeng Shi ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back ,  Ying Zheng

    发明人： Ronghua Liu ,  Xinfeng Shi ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back ,  Ying Zheng

    IPC分类号： G02C7/04

    CPC分类号： G02C7/04 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

    摘要： Silicone hydrogel contact lenses having ophthalmically acceptable levels of energy loss are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer which is a dual-end methacrylate end-capped polydimethylsiloxane having a number average molecular weight of at least 7,000 daltons. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

    摘要翻译： 描述了具有眼睛上可接受的能量损失水平的硅酮水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自第二硅氧烷单体的单元，其是数均分子量至少为7,000道尔顿的双末端甲基丙烯酸酯封端的聚二甲基硅氧烷。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

    Phosphine-Containing Hydrogel Contact Lenses
    6.
    发明申请
    Phosphine-Containing Hydrogel Contact Lenses 有权
    含磷的水凝胶隐形眼镜

    公开(公告)号：US20120220688A1

    公开(公告)日：2012-08-30

    申请号：US13404028

    申请日：2012-02-24

    申请人： Guigui Wang ,  Yun Zhang ,  Yuwen Liu ,  Ye Hong ,  Charlie Chen ,  Peter Zhu

    发明人： Guigui Wang ,  Yun Zhang ,  Yuwen Liu ,  Ye Hong ,  Charlie Chen ,  Peter Zhu

    IPC分类号： G02B1/04 ,  G02C7/04 ,  B65D85/00

    CPC分类号： G02B1/043 ,  A45C11/005 ,  B65D81/22 ,  C08L83/04

    摘要： Hydrogel contact lenses that are derived from a polymerizable composition including at least one hydrophilic monomer and at least one phosphine-containing component are described. The hydrogel of the contact lenses can be a silicone hydrogel or a non-silicone hydrogel. Use of polymerizable compositions comprising a phosphine-containing component can be cured under both inert and air atmospheres, and can be used to form hydrogel contact lenses having improved shape retention properties, having improved resistance to discoloration. Batches of hydrogel contact lenses and methods of making hydrogel contact lenses are also described.

    摘要翻译： 描述了衍生自包含至少一种亲水性单体和至少一种含膦组分的可聚合组合物的水凝胶隐形眼镜。 隐形眼镜的水凝胶可以是硅酮水凝胶或非硅氧水凝胶。 包含含膦组分的可聚合组合物的使用可以在惰性和空气气氛下固化，并且可用于形成具有改善的变色保持性能的具有改进的抗变色性的水凝胶隐形眼镜。 还描述了水凝胶隐形眼镜的批次和制备水凝胶隐形眼镜的方法。