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    NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER
    2.
    发明申请
    NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER 审中-公开
    新型杂环芳族化合物和聚合物

    公开(公告)号：US20110190461A1

    公开(公告)日：2011-08-04

    申请号：US13054425

    申请日：2008-09-10

    申请人： Yasuyuki Kita ,  Toshifumi Dohi ,  Koji Morimoto ,  Yoshiyuki Morita ,  Tetsuya Hosomi ,  Setsuko Ishioka

    发明人： Yasuyuki Kita ,  Toshifumi Dohi ,  Koji Morimoto ,  Yoshiyuki Morita ,  Tetsuya Hosomi ,  Setsuko Ishioka

    IPC分类号： C08F34/04 ,  C07D495/04 ,  C07D491/056

    CPC分类号： C08F28/06 ,  C07D495/04 ,  C08G61/123 ,  C08L65/00 ,  C09D5/24 ,  C09D201/00 ,  H01B1/127 ,  Y02P20/582

    摘要： A heterocycle-containing aromatic compound represented by the formula: A-B, and an electrically conductive polymer obtained by oxidative polymerization of the heterocycle-containing aromatic compound as a monomer are provided. In the above formula, A represents a substituted or unsubstituted thiophene ring group, or a substituted or unsubstituted pyrrole ring group; B represents a substituted or unsubstituted hydrocarbon aromatic ring group, a substituted or unsubstituted thiophene ring group, or a substituted or unsubstituted pyrrole ring group; the ring represented by A and the ring represented by B are directly linked; however, A and B represent structures that are different from each other. The compound can be produced by a coupling reaction using a hypervalent iodine reactant.

    摘要翻译： 提供由式-A-B表示的含杂环芳族化合物和通过含杂环芳香族化合物作为单体进行氧化聚合而得到的导电性聚合物。 在上式中，A表示取代或未取代的噻吩环基或取代或未取代的吡咯环基; B表示取代或未取代的烃芳族环基团，取代或未取代的噻吩环基团，或取代或未取代的吡咯环基团; 由A表示的环和由B表示的环直接连接; 然而，A和B表示彼此不同的结构。 该化合物可以通过使用高价碘反应物的偶联反应来制备。

    Connexin 26 inhibitor and cancer metastasis inhibitors
    3.
    发明申请
    Connexin 26 inhibitor and cancer metastasis inhibitors 审中-公开
    连接蛋白26抑制剂和癌症转移抑制剂

    公开(公告)号：US20060058379A1

    公开(公告)日：2006-03-16

    申请号：US10536805

    申请日：2003-11-28

    申请人： Yasuyuki Kita ,  Hiroshi Nojima ,  Akihiko Ito

    发明人： Yasuyuki Kita ,  Hiroshi Nojima ,  Akihiko Ito

    IPC分类号： A61K31/336

    CPC分类号： A61K31/336 ,  A61K31/16

    摘要： A connexin 26 inhibitor and a cancer metastasis inhibitor have a cis-oxirane structure and a terminal amide structure as represented by the following general formula (1): where R is a hydrogen atom or a hydrocarbon group, X is one of a hydrogen atom, a methansulfonyl group, an ethansulfonyl group, an acetyl group, a trifluoroacetyl group, a hydroxyl group, an alkoxy group and an amino group; m is an integer of from 4 to 10; and n is an integer of from 4 to 7. This compound is a novel cancer metastasis inhibitor which specifically inhibits the function of connexin 26.

    摘要翻译： 连接蛋白26抑制剂和癌症转移抑制剂具有如以下通式（1）所示的顺式 - 环氧乙烷结构和末端酰胺结构：

    NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER
    4.
    发明申请
    NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER 审中-公开
    新型杂环芳族化合物和聚合物

    公开(公告)号：US20120208978A1

    公开(公告)日：2012-08-16

    申请号：US13454867

    申请日：2012-04-24

    申请人： Yasuyuki KITA ,  Toshifumi DOHI ,  Koji MORIMOTO ,  Yoshiyuki MORITA ,  Tetsuya HOSOMI ,  Setsuko ISHIOKA

    发明人： Yasuyuki KITA ,  Toshifumi DOHI ,  Koji MORIMOTO ,  Yoshiyuki MORITA ,  Tetsuya HOSOMI ,  Setsuko ISHIOKA

    IPC分类号： C08G75/08 ,  C08G73/20 ,  C08G63/685

    CPC分类号： C08F28/06 ,  C07D495/04 ,  C08G61/123 ,  C08L65/00 ,  C09D5/24 ,  C09D201/00 ,  H01B1/127 ,  Y02P20/582

    摘要： An electrically conductive polymer obtained by oxidative polymerization of a heterocycle-containing aromatic compound as a monomer, wherein the heterocycle-containing aromatic compound is represented by the formula: A-B. In the above formula, A represents a substituted or unsubstituted thiophene ring group, or a substituted or unsubstituted pyrrole ring group; B represents a substituted or unsubstituted hydrocarbon aromatic ring group, a substituted or unsubstituted thiophene ring group, or a substituted or unsubstituted pyrrole ring group; the ring represented by A and the ring represented by B are directly linked; however, A and B represent structures that are different from each other. The compound can be produced by a coupling reaction using a hypervalent iodine reactant.

    摘要翻译： 通过含杂环芳香族化合物作为单体进行氧化聚合而得到的导电性聚合物，其中，所述含杂环芳香族化合物为下式：A-B所示。 在上式中，A表示取代或未取代的噻吩环基或取代或未取代的吡咯环基; B表示取代或未取代的烃芳族环基团，取代或未取代的噻吩环基团，或取代或未取代的吡咯环基团; 由A表示的环和由B表示的环直接连接; 然而，A和B表示彼此不同的结构。 该化合物可以通过使用高价碘反应物的偶联反应来制备。

    Apparatus and methods for measuring shape of both sides of a plate
    5.
    发明授权
    Apparatus and methods for measuring shape of both sides of a plate 有权
    用于测量板的两侧形状的装置和方法

    公开(公告)号：US07677121B2

    公开(公告)日：2010-03-16

    申请号：US11462737

    申请日：2006-08-07

    申请人： Shigetaka Akiyama ,  Shinichi Tanaka ,  Takanobu Akiyama ,  Katsunobu Ueda ,  Yasuyuki Kita

    发明人： Shigetaka Akiyama ,  Shinichi Tanaka ,  Takanobu Akiyama ,  Katsunobu Ueda ,  Yasuyuki Kita

    IPC分类号： G01M19/00 ,  B23Q17/09

    CPC分类号： G03F7/70791 ,  G01B11/306 ,  G03F1/60 ,  G03F1/84 ,  G03F7/70783

    摘要： In an apparatus for measuring shapes of both sides of a plate, a measuring apparatus body includes a reference plane of a longitudinal surface plate disposed in an almost vertical state at one end on a metallic bed, a holding mechanism for holding a plate to be measured in almost parallel therewith, and a displacement gauge scanning column. The displacement gauge scanning column includes a first air slide for mounting a first (second) displacement gauge and a second air slide for mounting a third displacement gauge, and is moved in a horizontal axis direction along a pair of V grooves. Moreover, the first (second) air slide is moved in a vertical axis direction. A shape of one of plate surfaces of the plate to be measured is measured by the scan of the first (second) displacement gauge, and at the same time, a shape of the other surface of the plate surface is measured by the scan of the third displacement gauge.

    摘要翻译： 在用于测量板的两侧的形状的装置中，测量装置主体包括在金属床的一端处于几乎垂直状态的纵向表面板的基准面，用于保持被测量板的保持机构 几乎与其平行，以及位移计扫描柱。 位移计扫描柱包括用于安装第一（第二）位移计的第一空气滑块和用于安装第三位移量规的第二空气滑块，并沿着一对V形槽在水平轴线方向上移动。 此外，第一（第二）空气滑块沿垂直轴方向移动。 通过第一（第二）位移计的扫描来测量要测量的板的一个板表面的形状，同时通过扫描板的表面来测量板表面的另一个表面的形状 第三排量规。

    Multimeric Oleamide Derivative Having Connexin-26 Inhibiting Potency and Use Thereof in Cancer Therapy, etc.
    6.
    发明申请
    Multimeric Oleamide Derivative Having Connexin-26 Inhibiting Potency and Use Thereof in Cancer Therapy, etc. 有权
    具有连接蛋白-26抑制效力及其在癌症治疗中的用途的多聚Oleamide衍生物等

    公开(公告)号：US20080089924A1

    公开(公告)日：2008-04-17

    申请号：US11718361

    申请日：2005-11-01

    申请人： Hiroshi Nojima ,  Yasuyuki Kita

    发明人： Hiroshi Nojima ,  Yasuyuki Kita

    IPC分类号： A61K47/00 ,  A61K31/16 ,  A61P35/00

    CPC分类号： C07C233/09 ,  A23L33/12 ,  A23V2002/00 ,  C07C233/38 ,  C07D303/36 ,  C07D303/46 ,  A23V2200/308 ,  A23V2250/188

    摘要： The present invention relates to multimeric oleamide derivatives having connexin 26 inhibitory activities and embraces the dimer oleamide derivatives represented by the following formula (1) or a pharmacologically acceptable salt thereof: where n denotes an integer of 3, 5, or 8. The novel oleamide derivatives of the present invention can be used not only as research reagents, but also in a wide industrial field because they exhibit useful bioactivities such as cancer metastasis/growth inhibition. Thus they have various applications, such as in medicines, supplements, and functional foods, in addition to cancer-preventive and cancer-therapeutic drugs.

    摘要翻译： 本发明涉及具有连接蛋白26抑制活性的多聚体油酰胺衍生物，并且包括由下式（1）表示的二聚油酰胺衍生物或其药理学上可接受的盐：其中n表示3,5或8的整数。新的油酰胺 本发明的衍生物不仅可以用作研究试剂，还可用于广泛的工业领域，因为它们表现出有用的生物活性，例如癌症转移/生长抑制。 因此，除了癌症预防和癌症治疗药物之外，它们具有各种应用，例如药物，补充剂和功能性食品。

    Multimeric oleamide derivative having connexin-26 inhibiting potency and use thereof in cancer therapy, etc
    7.
    发明授权
    Multimeric oleamide derivative having connexin-26 inhibiting potency and use thereof in cancer therapy, etc 有权
    具有连接蛋白-26抑制效力的多聚油酰胺衍生物及其在癌症治疗中的应用等

    公开(公告)号：US07846972B2

    公开(公告)日：2010-12-07

    申请号：US11718361

    申请日：2005-11-01

    申请人： Hiroshi Nojima ,  Yasuyuki Kita

    发明人： Hiroshi Nojima ,  Yasuyuki Kita

    IPC分类号： A01N37/18 ,  A61K31/195 ,  A61K47/00 ,  C07C233/00

    CPC分类号： C07C233/09 ,  A23L33/12 ,  A23V2002/00 ,  C07C233/38 ,  C07D303/36 ,  C07D303/46 ,  A23V2200/308 ,  A23V2250/188

    摘要： The present invention relates to multimeric oleamide derivatives having connexin 26 inhibitory activities and embraces the dimer oleamide derivatives represented by the following formula (1) or a pharmacologically acceptable salt thereof: where n denotes an integer of 3, 5, or 8. The novel oleamide derivatives of the present invention can be used not only as research reagents, but also in a wide industrial field because they exhibit useful bioactivities such as cancer metastasis/growth inhibition. Thus they have various applications, such as in medicines, supplements, and functional foods, in addition to cancer-preventive and cancer-therapeutic drugs.

    摘要翻译： 本发明涉及具有连接蛋白26抑制活性的多聚体油酰胺衍生物，并且包括由下式（1）表示的二聚油酰胺衍生物或其药理学上可接受的盐：其中n表示3,5或8的整数。新的油酰胺 本发明的衍生物不仅可以用作研究试剂，还可用于广泛的工业领域，因为它们表现出有用的生物活性，例如癌症转移/生长抑制。 因此，除了癌症预防和癌症治疗药物之外，它们具有各种应用，例如药物，补充剂和功能性食品。

    APPARATUS AND METHODS FOR MEASURING SHAPE OF BOTH SIDES OF A PLATE
    8.
    发明申请
    APPARATUS AND METHODS FOR MEASURING SHAPE OF BOTH SIDES OF A PLATE 有权
    测量板的两面形状的装置和方法

    公开(公告)号：US20070184356A1

    公开(公告)日：2007-08-09

    申请号：US11462737

    申请日：2006-08-07

    申请人： SHIGETAKA AKIYAMA ,  SHINICHI TANAKA ,  TAKANOBU AKIYAMA ,  KATSUNOBU UEDA ,  YASUYUKI KITA

    发明人： SHIGETAKA AKIYAMA ,  SHINICHI TANAKA ,  TAKANOBU AKIYAMA ,  KATSUNOBU UEDA ,  YASUYUKI KITA

    IPC分类号： G03F1/00

    CPC分类号： G03F7/70791 ,  G01B11/306 ,  G03F1/60 ,  G03F1/84 ,  G03F7/70783

    摘要： In an apparatus for measuring shapes of both sides of a plate, a measuring apparatus body includes a reference plane of a longitudinal surface plate disposed in an almost vertical state at one end on a metallic bed, a holding mechanism for holding a plate to be measured in almost parallel therewith, and a displacement gauge scanning column. The displacement gauge scanning column includes a first air slide for mounting a first (second) displacement gauge and a second air slide for mounting a third displacement gauge, and is moved in a horizontal axis direction along a pair of V grooves. Moreover, the first (second) air slide is moved in a vertical axis direction. A shape of one of plate surfaces of the plate to be measured is measured by the scan of the first (second) displacement gauge, and at the same time, a shape of the other surface of the plate surface is measured by the scan of the third displacement gauge.

    摘要翻译： 在用于测量板的两侧的形状的装置中，测量装置主体包括在金属床的一端处于几乎垂直状态的纵向表面板的基准面，用于保持被测量板的保持机构 几乎与其平行，以及位移计扫描柱。 位移计扫描柱包括用于安装第一（第二）位移计的第一空气滑块和用于安装第三位移量规的第二空气滑块，并沿着一对V形槽在水平轴线方向上移动。 此外，第一（第二）空气滑块沿垂直轴方向移动。 通过第一（第二）位移计的扫描来测量要测量的板的一个板表面的形状，同时通过扫描板的表面来测量板表面的另一个表面的形状 第三排量规。